标签归档：lr

1840-100   Microcystin-LR   品牌 Biovision

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Microcystin-LR

货号： 1840-100      产品名称： Microcystin-LR   品牌： Biovision 规格： 100 μg 3周到货 生化实验

Microcystin-LR
A protein phosphatase 1 (PP1) inhibitor
Product Overview
Product Name: Microcystin-LR
Alternate Name/Synonyms: Cyanoginosin-LR
Description: A hepatotoxic cyclic heptapeptide toxin produced by cyanobacteria. A selective inhibitor of protein phosphatase 1 (PP1) (IC₅₀ = 1.7 nM) and protein phosphatase 2A (PP2A) (IC₅₀ = 0.04 nM). Less sensitive to PP2B and does not inhibit PP2C up to 4 µM.
Peptide Sequence: N/A
Appearance: Whitish film
Formulation: N/A
CAS Number: 101043-37-2
Molecular Formula: C₄₉H₇₄N₁₀O₁₂
Molecular Weight: 995.17
Purity: ≥95% by HPLC
Solubility:DMSO or EtOH or MeOH
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C
InChi: InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1
InChi Key: ZYZCGGRZINLQBL-GWRQVWKTSA-N
PubChem CID: 445434
MDL Number: MFCD01774058
USAGE: For Research Use Only! Not For Use in Humans.

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1840-500   Microcystin-LR   品牌 Biovision

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Microcystin-LR

货号： 1840-500      产品名称： Microcystin-LR   品牌： Biovision 规格： 500 μg 3周到货 生化实验

Microcystin-LR
A protein phosphatase 1 (PP1) inhibitor
Product Overview
Product Name: Microcystin-LR
Alternate Name/Synonyms: Cyanoginosin-LR
Description: A hepatotoxic cyclic heptapeptide toxin produced by cyanobacteria. A selective inhibitor of protein phosphatase 1 (PP1) (IC₅₀ = 1.7 nM) and protein phosphatase 2A (PP2A) (IC₅₀ = 0.04 nM). Less sensitive to PP2B and does not inhibit PP2C up to 4 µM.
Peptide Sequence: N/A
Appearance: Whitish film
Formulation: N/A
CAS Number: 101043-37-2
Molecular Formula: C₄₉H₇₄N₁₀O₁₂
Molecular Weight: 995.17
Purity: ≥95% by HPLC
Solubility:DMSO or EtOH or MeOH
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C
InChi: InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1
InChi Key: ZYZCGGRZINLQBL-GWRQVWKTSA-N
PubChem CID: 445434
MDL Number: MFCD01774058
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

BML-P229-0010   Z-LR-AMC (Fluorogenic Substrate)   品牌 Biomol

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Z-LR-AMC (Fluorogenic Substrate)

货号： BML-P229-0010      产品名称： Z-LR-AMC (Fluorogenic Substrate)   品牌： Biomol 规格： 10 mg 3周到货 生化实验

Sensitive fluorogenic substrate for cathepsin K (Km=8µM, kcat/Km=4 x 10 M-1s-1). This substrate is also cleaved by cathepsin B, F, L, L2/V, S. Z-LR-AMC is also cleaved by malaria parasite cysteine proteases falcipain-1, -2, -3, berghepain, and vivapain-2, -3. Ex.: 365nm, Em.: 440nm, although the following Ex/Em can also be used: 355,380/450,460. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).
Product Specification
Alternative Name:Z-Leu-Arg-AMC, Cathepsin K substrate (fluorogenic)
Sequence:Z-Leu-Arg-AMC•HCl[Z=Cbz=Benzyloxycarbonyl;AMC=7-amino-4-methylcoumarin]
MW:578.7
Purity:97%
Long Term Storage:-20°C

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10007188-100   Microcystin-LR   品牌 Cayman

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Microcystin-LR

货号： 10007188-100      产品名称： Microcystin-LR   品牌： Cayman 规格： 100 碌g 3周

Microcystin-LR
Cayman Chemical Item Number 10007188
Description Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.1↗ They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50=0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2↗ The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.
Synonyms Cyanoginosin-LR
Toxin T 17 (Microcystis aeruginosa)
Formal Name cyclo[2,​3-​didehydro-​N-​methylalanyl-​D-​alanyl-​L-​leucyl-​(3S)-​3-​methyl-​D-​β-​aspartyl-​L-​arginyl-​(2S,​3S,​4E,​6E,​8S,​9S)-​3-​amino-​9-​methoxy-​2,​6,​8-​trimethyl-​10-​phenyl-​4,​6-​decadienoyl-​D-​γ-​glutamyl]
CAS Number 101043-37-2
Molecular Formula C49H74N10O12
Formula Weight 995.2
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@@H]​(/C=C(/C=C/[C@@H]​(NC([C@H]​(CCCNC(N)​=N)​NC([C@@H]​(C)​[C@H]​(C(O)​=O)​NC1=O)​=O)​=O)​[C@H]​(C)​C(N[C@@H]​(C(O)​=O)​CCC(N(C(C(N[C@H]​(C)​C(N[C@H]​1CC(C)​C)​=O)​=O)​=C)​C)​=O)​=O)​C)​[C@@H]​(OC)​CC2=CC=CC=C2 
InCHI Code 1S/C49H74N10O12/c1-26(2)​23-37-46(66)​58-40(48(69)​70)​30(6)​42(62)​55-35(17-14-22-52-49(50)​51)​45(65)​54-34(19-18-27(3)​24-28(4)​38(71-10)​25-33-15-12-11-13-16-33)​29(5)​41(61)​56-36(47(67)​68)​20-21-39(60)​59(9)​32(8)​44(64)​53-31(7)​43(63)​57-37/h11-13,15-16,18-1 
InCHI Key ZYZCGGRZINLQBL-DABAWSACSA-N

-20°C

10007188-50   Microcystin-LR   品牌 Cayman

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Microcystin-LR

货号： 10007188-50      产品名称： Microcystin-LR   品牌： Cayman 规格： 50 碌g 3周

Microcystin-LR
Cayman Chemical Item Number 10007188
Description Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.1↗ They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50=0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2↗ The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.
Synonyms Cyanoginosin-LR
Toxin T 17 (Microcystis aeruginosa)
Formal Name cyclo[2,​3-​didehydro-​N-​methylalanyl-​D-​alanyl-​L-​leucyl-​(3S)-​3-​methyl-​D-​β-​aspartyl-​L-​arginyl-​(2S,​3S,​4E,​6E,​8S,​9S)-​3-​amino-​9-​methoxy-​2,​6,​8-​trimethyl-​10-​phenyl-​4,​6-​decadienoyl-​D-​γ-​glutamyl]
CAS Number 101043-37-2
Molecular Formula C49H74N10O12
Formula Weight 995.2
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@@H]​(/C=C(/C=C/[C@@H]​(NC([C@H]​(CCCNC(N)​=N)​NC([C@@H]​(C)​[C@H]​(C(O)​=O)​NC1=O)​=O)​=O)​[C@H]​(C)​C(N[C@@H]​(C(O)​=O)​CCC(N(C(C(N[C@H]​(C)​C(N[C@H]​1CC(C)​C)​=O)​=O)​=C)​C)​=O)​=O)​C)​[C@@H]​(OC)​CC2=CC=CC=C2 
InCHI Code 1S/C49H74N10O12/c1-26(2)​23-37-46(66)​58-40(48(69)​70)​30(6)​42(62)​55-35(17-14-22-52-49(50)​51)​45(65)​54-34(19-18-27(3)​24-28(4)​38(71-10)​25-33-15-12-11-13-16-33)​29(5)​41(61)​56-36(47(67)​68)​20-21-39(60)​59(9)​32(8)​44(64)​53-31(7)​43(63)​57-37/h11-13,15-16,18-1 
InCHI Key ZYZCGGRZINLQBL-DABAWSACSA-N

-20°C

10007188-500   Microcystin-LR   品牌 Cayman

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Microcystin-LR

货号： 10007188-500      产品名称： Microcystin-LR   品牌： Cayman 规格： 500 碌g 3周

Microcystin-LR
Cayman Chemical Item Number 10007188
Description Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.1↗ They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50=0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2↗ The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.
Synonyms Cyanoginosin-LR
Toxin T 17 (Microcystis aeruginosa)
Formal Name cyclo[2,​3-​didehydro-​N-​methylalanyl-​D-​alanyl-​L-​leucyl-​(3S)-​3-​methyl-​D-​β-​aspartyl-​L-​arginyl-​(2S,​3S,​4E,​6E,​8S,​9S)-​3-​amino-​9-​methoxy-​2,​6,​8-​trimethyl-​10-​phenyl-​4,​6-​decadienoyl-​D-​γ-​glutamyl]
CAS Number 101043-37-2
Molecular Formula C49H74N10O12
Formula Weight 995.2
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@@H]​(/C=C(/C=C/[C@@H]​(NC([C@H]​(CCCNC(N)​=N)​NC([C@@H]​(C)​[C@H]​(C(O)​=O)​NC1=O)​=O)​=O)​[C@H]​(C)​C(N[C@@H]​(C(O)​=O)​CCC(N(C(C(N[C@H]​(C)​C(N[C@H]​1CC(C)​C)​=O)​=O)​=C)​C)​=O)​=O)​C)​[C@@H]​(OC)​CC2=CC=CC=C2 
InCHI Code 1S/C49H74N10O12/c1-26(2)​23-37-46(66)​58-40(48(69)​70)​30(6)​42(62)​55-35(17-14-22-52-49(50)​51)​45(65)​54-34(19-18-27(3)​24-28(4)​38(71-10)​25-33-15-12-11-13-16-33)​29(5)​41(61)​56-36(47(67)​68)​20-21-39(60)​59(9)​32(8)​44(64)​53-31(7)​43(63)​57-37/h11-13,15-16,18-1 
InCHI Key ZYZCGGRZINLQBL-DABAWSACSA-N

-20°C

M3408-25 μg   Microcystin LR, desmethyl (“Asp3-MCLR”)   品牌 LKT

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Microcystin LR, desmethyl ("Asp3-MCLR")

货号： M3408-25 μg      产品名称： Microcystin LR, desmethyl (“Asp3-MCLR”)   品牌： LKT 规格： 25 μg 三周到货 生化试验

[D-Asp3] Microcystin-LR
Description
This compound ships with Blue Ice. Please choose shipping accordingly.*
Microcystin LR is a cyclic heptapeptide produced by species of cyanobacteria Microcystis. Microcystin LR exhibits cytotoxic, pro-oxidative, and carcinogenic properties. Microcystin LR is particularly toxic to the liver, increasing cytochrome c release and expression of Bax and caspases 3, 8, and 9; microcystin LR also decreases expression of Bcl-2. In testicular cells, this toxin increases expression of c-KIT and induces apoptosis, causing a decrease in tubular diameter and testes weight. This compound also induces cytoskeletal reorganization, increasing phosphorylation of VASP and tau and also increasing dissociation of tau from the cytoskeleton. In vitro, Microcystin LR inhibits protein phosphatases 1 (PP1) and 2A (PP2A) and induces oxidative damage by increasing levels of ROS and malondialdehyde and decreasing levels of glutathione and glutathione peroxidase. Microcystin LR also produces cognitive deficit in vivo, potentially through activation of glycogen synthase kinase-3β (GSK-3β). This compound also activates Nrf2 in cancer cells.
Specifications 
Cas No. 120011-66-7
Product ID  M3408
Product Name  [D-Asp3] Microcystin-LR
Synonym desmethyl microcystin LR, Asp3-MCLR
Formula C48H72N10O12
Formula Wt. 981.2
Purity ≥95% 
Store Temp -20oC
Ship Temp Blue Ice
References Zhou Y, Chen Y, Yuan M, et al. In vivo study on the effects of microcystin-LR on the apoptosis, proliferation and differentiation of rat testicular spermatogenic cells of male rats injected i.p. with toxins. J Toxicol Sci. 2013;38(5):661-70. PMID: 24025782.
Sun Y, Liu JH, Huang P, et al. Alterations of tau and VASP during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line. Environ Toxicol. 2013 Aug 9. doi:. [Epub ahead of print]. PMID: 23929704.
Zhang H, Cai C, Fang W, et al. Oxidative damage and apoptosis induced by microcystin-LR in the liver of Rana nigromaculata in vivo. Aquat Toxicol. 2013 Sep 15;140-141:11-8. PMID: 23747548.
Wang J, Lin F, Cai F, et al. Microcystin-LR inhibited hippocampal long-term potential via regulation of the glycogen synthase kinase-3β pathway. Chemosphere. 2013 Sep;93(2):223-9. PMID: 23701903.
Liang J, Li T, Zhang YL, etal. Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells. J Zhejiang Univ Sci B. 2011 Dec;12(12):951-60. PMID: 22135143.
Gan N, Sun X, Song L. Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. Chem Res Toxicol. 2010 Sep 20;23(9):1477-84. PMID: 20722399. 
 

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ALX-350-012-C050   现货|Microcystin-LR|微囊藻毒素LR   品牌 Alexis

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现货|Microcystin-LR|微囊藻毒素LR

货号： ALX-350-012-C050      产品名称： 现货|Microcystin-LR|微囊藻毒素LR   品牌： Alexis 规格： 50UG 现货 生化实验

Microcystin-LR
Inhibitor of PP1 and PP2A
Heptapeptide ester hepatotoxin. Tumor promoter. Equally potent and selective inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). PP2B is less sensitive and PP2C is not inhibited up to 4µM. Useful for affinity-purification of PP2A. The product is not cell permeable except in liver cells, which appear to have a functional uptake system. Is absorbed by hepatocytes via the multispecific organic anion transporter. Does not induce any effects on mouse skin or human fibroblasts due to cell membranes impermeability. Has no effect on protein kinases. Less toxic than the more hydrophobic analogs microcystin-LY, -LW and -LF. Frequently contaminates fresh-water lakes and ponds. Causes livestock poisonings. Ozonation did lead to complete loss of toxicity and toxins from contaminated samples.
Product Specification
Formula: C49H74N10O12
MW: 995.2
Source: Isolated from Microcystis aeruginosa.
CAS: 101043-37-2
RTECS: GT2810000
Purity: ≥95% (HPLC)
Identity: Identity determined by MS.
Appearance: Whitish film adhered to inside of the vial.
Hazard: HIGHLY IRRITANT.
        MAY BE CARCINOGENIC.
        VERY TOXIC.
Solubility: Soluble in 100% ethanol, methanol or DMSO.
Long Term Storage: -20°C
Use/Stability: Stock solutions are stable for up to 6 months when stored at -20°C. Unstable at pH>7.7.
Handling: For maximum product recovery after thawing, centrifuge the vial before opening the cap.

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