Microcystin-LR

货号： 10007188-50      产品名称： Microcystin-LR   品牌： Cayman 规格： 50 碌g 3周

Microcystin-LR
Cayman Chemical Item Number 10007188
Description Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.1↗ They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50=0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2↗ The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.
Synonyms Cyanoginosin-LR
Toxin T 17 (Microcystis aeruginosa)
Formal Name cyclo[2,​3-​didehydro-​N-​methylalanyl-​D-​alanyl-​L-​leucyl-​(3S)-​3-​methyl-​D-​β-​aspartyl-​L-​arginyl-​(2S,​3S,​4E,​6E,​8S,​9S)-​3-​amino-​9-​methoxy-​2,​6,​8-​trimethyl-​10-​phenyl-​4,​6-​decadienoyl-​D-​γ-​glutamyl]
CAS Number 101043-37-2
Molecular Formula C49H74N10O12
Formula Weight 995.2
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@@H]​(/C=C(/C=C/[C@@H]​(NC([C@H]​(CCCNC(N)​=N)​NC([C@@H]​(C)​[C@H]​(C(O)​=O)​NC1=O)​=O)​=O)​[C@H]​(C)​C(N[C@@H]​(C(O)​=O)​CCC(N(C(C(N[C@H]​(C)​C(N[C@H]​1CC(C)​C)​=O)​=O)​=C)​C)​=O)​=O)​C)​[C@@H]​(OC)​CC2=CC=CC=C2 
InCHI Code 1S/C49H74N10O12/c1-26(2)​23-37-46(66)​58-40(48(69)​70)​30(6)​42(62)​55-35(17-14-22-52-49(50)​51)​45(65)​54-34(19-18-27(3)​24-28(4)​38(71-10)​25-33-15-12-11-13-16-33)​29(5)​41(61)​56-36(47(67)​68)​20-21-39(60)​59(9)​32(8)​44(64)​53-31(7)​43(63)​57-37/h11-13,15-16,18-1 
InCHI Key ZYZCGGRZINLQBL-DABAWSACSA-N

-20°C