标签归档：jnk

PS1019-100UL   PD ANTI-JNK1&2 (PTHR183/PTYR185) RB PAB   品牌 Merck

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PD ANTI-JNK1&2 (PTHR183/PTYR185) RB PAB

货号： PS1019-100UL      产品名称： PD ANTI-JNK1&2 (PTHR183/PTYR185) RB PAB   品牌： Merck 规格： *** 3周到货 生化实验

PhosphoDetect™ Anti-JNK1/2 (pThr¹83/Tyr¹85) Rabbit pAb
Anti-c-Jun N-terminal Kinase 1&2, Phospho-Specific (Thr/Tyr183/185)
Recognizes the ~49 kDa JNK1 and the ~55 kDa JNK2 phosphorylated at Thr183 and Tyr185 in uv-treated HEK293 cells.
产品信息
Host  Rabbit
Isotype  IgG
Immunogen  a synthetic phosphopeptide corresponding to amino acids surrounding the Thr¹83 and Tyr¹85 phosphorylation sites of human JNK1 and JNK2
Form  Liquid
Formulation  In Dulbecco’s PBS (without Mg2+ and Ca2+), 1 mg/ml BSA, 50% glycerol, pH 7.2-7.4.
Species reactivity  human, mouse, rat
Preservative  ≤0.1% sodium azide
Applications 
Immunoblotting (Western Blotting)
Avoid freeze/thaw  是的
Positive control  UV-treated HEK293 cells or sorbitol-treated PC12 cells
商店和运输信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Standard Handling

-20°C

V3821   JNK3 Kinase Enzyme System   品牌 Promega

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JNK3 Kinase Enzyme System

货号： V3821      产品名称： JNK3 Kinase Enzyme System   品牌： Promega 规格： 10μg 二周到货 生化试验

说明 
 在 Sf9 昆虫细胞中，我们通过杆状病毒 表达 N 端带 GST 标签的 重组 全长人源 JNK3 。 JNK3 是 c-Jun N 末端激酶（ JNKs ）家族的成员，该家族属于分裂素激活蛋白（MAP ）激酶家族，能调控环境胁迫引起的信号转导。 JNK3 磷酸化许多转录因子，如 ATF2 、 Elk-1 、以及 Jun 家族成员。在海马体中， JNK3 （神经元特异的 JNK 异构体）的激活与细胞核定位，与 CA1 神经元的缺氧和缺血损伤相关。缺失 JNK3 的基因敲除小鼠表现出海马体神经元细胞凋亡的减少、以及红藻氨酸（谷氨酸受体拮抗剂）诱导的捕获能力降低。
ADP-Glo™ Kinase Assay （ADP-Glo™ 激酶检测试剂盒） 是一种发光法激酶检测试剂盒，用于 检测 激酶反应产生的 ADP 含量： ADP 转化为 ATP 后， ATP 即可作为 Ultra-Glo™ 萤光素酶 催化反应的底物，产生光信号。发光信号与 ADP 的量和激酶活性正相关。 该试剂盒适合检测化合物对纯化的多种激酶活性的影响，使之成为初筛和激酶选择性概况分析的理想工具。 ADP-Glo™ 激酶检测试剂盒可用于检测几乎所有可生成 ADP 的酶类 ( 如激酶或 ATP 酶 ) 的活性， ATP 浓度可高达 1 mM 。
激酶酶系统的组成：
•  激酶： JNK3 ， 10μg ( 人源，重组全长蛋白 ) ； MW : ~ 71 kDa 。
•  底物： p38 peptide 。
•  其它组分： 反应缓冲液， DTT 。
JNK3 NCBI 数据库入口。
人类激酶酶系统及其应用。
特点  •  在实验室内即可筛选更多的化合物： ADP-Glo™ 激酶检测试剂盒 与激酶酶系统的优化组合，使您可以迅速方便地开始实验。
•  完整的系统： 激酶酶系统包含重组激酶、激酶的最适底物、反应缓冲液、以及使用前需加入缓冲液的 DTT 和 MnCl 2 。
•  可得到可靠结果： ADP-Glo™ 激酶检测试剂盒提供了宽广的动态范围、方便的操作方法、以及更好的灵敏度，产生的数据更可靠。

7757-100   JNK1, Active   品牌 Biovision

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JNK1, Active

货号： 7757-100      产品名称： JNK1, Active   品牌： Biovision 规格： 100 μg 3周到货 生化实验

Active JNK1
Kinases that bind and phosphorylate c-Jun
Product Overview
Alternate Names / Synonyms: JNK-1, JNK 1, Active JNK1, JNK1, JNK, mouse JNK1, active kinase, active kinases, recombinant JNK1, recombinant JNK, kinase activity assay, protein kinase
Gene Symbol: JNK1
Accession #: P45983
Gene ID: 5599
Source: Baculovirus (Sf9 insect cells)
Appearance: Liquid
Physical Form Description: Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Molecular Weight: 71.0 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: The specific activity of JNK1 was determined to be 124 nmol /min/mg as per activity assay protocol.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: dry ice
Background Information: JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.

-80°C

7757-5   JNK1, Active   品牌 Biovision

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JNK1, Active

货号： 7757-5      产品名称： JNK1, Active   品牌： Biovision 规格： 5 μg 3周到货 生化实验

Active JNK1
Kinases that bind and phosphorylate c-Jun
Product Overview
Alternate Names / Synonyms: JNK-1, JNK 1, Active JNK1, JNK1, JNK, mouse JNK1, active kinase, active kinases, recombinant JNK1, recombinant JNK, kinase activity assay, protein kinase
Gene Symbol: JNK1
Accession #: P45983
Gene ID: 5599
Source: Baculovirus (Sf9 insect cells)
Appearance: Liquid
Physical Form Description: Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Molecular Weight: 71.0 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: The specific activity of JNK1 was determined to be 124 nmol /min/mg as per activity assay protocol.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: dry ice
Background Information: JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.

-80°C

7031-1   JNK Negative Control Cell Lysate   品牌 Biovision

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JNK Negative Control Cell Lysate

货号： 7031-1      产品名称： JNK Negative Control Cell Lysate   品牌： Biovision 规格： 1 mg 3周到货 生化实验

JNK Negative Control Cell Lysate
Product Overview
Product Highlights:
• CONCENTRATION- 4 mg/ml
Description: The cell Lysate prepared from uninduced Jurkat cells can be used as a negative control for JNK activity assays in conjunction with BioVision’s JNK Activity Assay Kit (K430-40 or K431-40). We recommend using 100 µg per assay.
Storage Temp.: -70°C
Shipping: dry ice
Usage: For Research Use Only! Not For Use in Humans.

-70°C

7032-1   JNK Activated Cell Lysate   品牌 Biovision

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JNK Activated Cell Lysate

货号： 7032-1      产品名称： JNK Activated Cell Lysate   品牌： Biovision 规格： 1 mg 3周到货 生化实验

JNK Activated Cell Lysate
Product Overview
Product Highlights:
• CONCENTRATION- 4 mg/ml
Description: Jurkat cells are cultured in RPMI medium supplement with 10% FBS. The cells were grown to late growing phase. Anisomycin is added to the medium to a final concentration 10 µg/ml (BioVision cat# 1549-10, dissolved in DMSO to 10 mg/ml as stock). The cells are incubated at 37°C for 15 minutes, then collected and lysed in Extraction Buffer (BioVision Cat # K430-40). The cell lysate can be used as a positive control for JNK activity assays in conjunction with BioVision’s JNK Activity Assay Kit (K430-40 or K431-40). For positive controls, we recommend using 100 µg per assay.
Storage Temp.: -70°C
Shipping: dry ice
Usage: For Research Use Only! Not For Use in Humans.

-70°C

420144-10MG   JNK Inhibitor XIII   品牌 Merck

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JNK Inhibitor XIII

货号： 420144-10MG      产品名称： JNK Inhibitor XIII   品牌： Merck 规格： *** 3周到货 生化实验

JNK Inhibitor XIII
Form  Pale yellow solid
Molar mass  261.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C5H3N5O2S3
CAS number  40045-50-9
商店和运输信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Standard Handling

-20°C

420147-10MG   JNK Inhibitor XIII, SR-3306   品牌 Merck

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JNK Inhibitor XIII, SR-3306

货号： 420147-10MG      产品名称： JNK Inhibitor XIII, SR-3306   品牌： Merck 规格： *** 3周到货 生化实验

JNK Inhibitor XIV, SR-3306
Form  Pale yellow powder
Molar mass  490.6
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C28H26N8O
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling

2°C – 8°C

420150-10MG   JNK Inhibitor XVI, JNK-IN-8   品牌 Merck

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JNK Inhibitor XVI, JNK-IN-8

货号： 420150-10MG      产品名称： JNK Inhibitor XVI, JNK-IN-8   品牌： Merck 规格： *** 3周到货 生化实验

JNK Inhibitor XVI, JNK-IN-8
Form  Light beige powder
Primary Target  JNK1, JNK2, JNK3
Molar mass  507.6
Protect from Light  是的
Packaged under inert gas  是的
Cell permeable  是的
Purity  ≥97% by HPLC
Solubility  DMSO
Chemical formula  C29H29N7O2
Declaration  Licensed under pending patent from Dana-Farber Cancer Institute.
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling

2°C – 8°C

BML-SE320-0005   JNK3 (human) (recombinant)   品牌 Biomol

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JNK3 (human) (recombinant)

货号： BML-SE320-0005      产品名称： JNK3 (human) (recombinant)   品牌： Biomol 规格： 5 ug 3周到货 生化实验

NK3 (human), (recombinant) (His-tag)
Product Specification
Alternative Name:MAPK10, MAP kinase 10
MW:52 kDa
Source:Produced in a cell free expression system. Active full length JNK3.
UniProt ID:P53779
Formulation:Liquid. In HEPES, pH 8.0, containing NaCl, DTT and glycerol.
Long Term Storage:-80°C
Miscellaneous/General:JNKs are members of the MAP kinase family that activate the Jun transcription factor and are activated by treatment of cells with IL-1. JNK3 is found in the hippocampus and neocortex areas of the brain and the distribution of JNK3-expressing neurons in these areas matches the distribution of neurons targeted by Alzheimer’s disease.

-80°C

420149-25MG   JNK Inhibitor XV, IQ-1S   品牌 Merck

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JNK Inhibitor XV, IQ-1S

货号： 420149-25MG      产品名称： JNK Inhibitor XV, IQ-1S   品牌： Merck 规格： *** 3周到货 生化实验

JNK Inhibitor XV, IQ-1S
Form  Bright yellow solid
Primary Target  JNK1,2,3
Secondary target  PI 3-Kγ, CK1δ and MKNK2
Molar mass  269.2
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Cell permeable  是的
Reversible  是的
Purity  ≥95% by HPLC
Solubility  DMSO
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling

-20°C