IkappaBalpha (Untagged) (human) (recombinant)

货号： BML-UW9975-0050      产品名称： IkappaBalpha (Untagged) (human) (recombinant)   品牌： Biomol 规格： 50 ug 3周到货 生化试验

IκBα (human), (recombinant) (untagged)
Product Specification
Source: Produced in E. coli.
UniProt ID: P25963
Application: 1. NF-κB pathway studies, inhibition of NF-κB p50/p65, substrate for IκB kinase (IKK). 2.Investigation of IκBα phosphorylation/ubiquitinylation/SUMOylation. 3. Ubiquitin-proteasome mediated degradation studies.
Long Term Storage: -80°C
Miscellaneous/General: IκBa inhibits activation of the NF-κB pathway activation by associating with the major NF-κB heterodimeric complex p50/p65 and preventing its translocation from the cytoplasm into the nucleus, where it acts a transcription factor for genes involved in inflammation, autoimmune response, cell proliferation, and apoptosis. Inhibition of NF-κB pathway activation by IκBα is controlled by its sequential serine-phosphorylation, ubiquitination and proteasomal degradation. This process itself can be inhibited by SUMOylation of IκBα, providing an additional regulatory step for the activation of the NF-κB pathway.

-80°C