pFUSE-hIgG1e1-Fc1

货号： pfc1-hg1e1      产品名称： pFUSE-hIgG1e1-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e1-Fc
pFUSE-hIgG1e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated T250Q/M428L and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: T250Q/M428L
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e11-Fc1

货号： pfc1-hg1e11      产品名称： pFUSE-hIgG1e11-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e11-Fc
pFUSE-hIgG1e11-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M252Y/S254T/T256E and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e11-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M252Y /S254T/T256E
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e12-Fc1

货号： pfc1-hg1e12      产品名称： pFUSE-hIgG1e12-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e12-Fc
pFUSE-hIgG1e12-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M428L/N434A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e12-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M428L/N434A
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e13-Fc1

货号： pfc1-hg1e13      产品名称： pFUSE-hIgG1e13-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e13-Fc
pFUSE-hIgG1e13-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated I253A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e13-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutation: I253A
Characteristics:
– Decreased binding to FcRn
– Decreased half-life (enhanced antibody clearance)
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e2-Fc1

货号： pfc1-hg1e2      产品名称： pFUSE-hIgG1e2-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e2-Fc
pFUSE-hIgG1e2-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. The engineered hIgG1e2 Fc contains the following mutations: M252Y/S254T/T256E and H433K/N434F.
pFUSE-hIgG1e2-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M252Y/S254T/T256E + H433K/N434F
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e3-Fc1

货号： pfc1-hg1e3      产品名称： pFUSE-hIgG1e3-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e3-Fc
pFUSE-hIgG1e3-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.  The engineered hIgG1e3 Fc contains the following mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S.
pFUSE-hIgG1e3-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
DISCLAIMER: pFUSE-hIgG1e3 plasmids featuring the IgG1e3 engineered Fc are sold by InvivoGen under a limited license from Cambridge Enterprise Limited (International Publication Number WO 99/58572).
Isotype: IgG1 human
Mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S
Characteristics:
– Reduced binding to FcγRI
– Reduced ADCC and CDC
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e4-Fc1

货号： pfc1-hg1e4      产品名称： pFUSE-hIgG1e4-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e4-Fc
pFUSE-hIgG1e4-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated E333 and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e4-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutation: E333A
Characteristics:
– Increased binding to FcγRIIIa
– Increased ADCC and CDC
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e5-Fc1

货号： pfc1-hg1e5      产品名称： pFUSE-hIgG1e5-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e5-Fc
pFUSE-hIgG1e5-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S239D/A330L/I332E and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e5-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: S239D/A330L/I332E
Characteristics:
– Increased binding to FcγRIIIa
– Increased ADCC
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e6-Fc1

货号： pfc1-hg1e6      产品名称： pFUSE-hIgG1e6-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e6-Fc
pFUSE-hIgG1e6-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated P257I/Q311I and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e5-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: P257I/Q311I
Characteristics:
– Increased binding to FcgRIIIA
– Unchanged half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e7-Fc1

货号： pfc1-hg1e7      产品名称： pFUSE-hIgG1e7-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e7-Fc
pFUSE-hIgG1e7-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated K326W/E333S and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e7-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: K326W/E333S
Characteristics:
– Increased CDC
– Increased binding to C1q
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG4e1-Fc1

货号： pfc1-hg4e1      产品名称： pFUSE-hIgG4e1-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG4e1-Fc
pFUSE-hIgG4e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S228P and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG4e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype : IgG4 human
Mutation: S228P
Characteristics:
– Reduced Fab-arm exchange
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e11-Fc2

货号： pfc2-hg1e11      产品名称： pFUSE-hIgG1e11-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e11-Fc
pFUSE-hIgG1e11-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M252Y/S254T/T256E and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e11-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M252Y /S254T/T256E
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e12-Fc2

货号： pfc2-hg1e12      产品名称： pFUSE-hIgG1e12-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e12-Fc
pFUSE-hIgG1e12-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M428L/N434A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e12-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M428L/N434A
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e13-Fc2

货号： pfc2-hg1e13      产品名称： pFUSE-hIgG1e13-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e13-Fc
pFUSE-hIgG1e13-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated I253A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e13-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutation: I253A
Characteristics:
– Decreased binding to FcRn
– Decreased half-life (enhanced antibody clearance)
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e3-Fc2

货号： pfc2-hg1e3      产品名称： pFUSE-hIgG1e3-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e3-Fc
pFUSE-hIgG1e3-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.  The engineered hIgG1e3 Fc contains the following mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S.
pFUSE-hIgG1e3-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
DISCLAIMER: pFUSE-hIgG1e3 plasmids featuring the IgG1e3 engineered Fc are sold by InvivoGen under a limited license from Cambridge Enterprise Limited (International Publication Number WO 99/58572).
Isotype: IgG1 human
Mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S
Characteristics:
– Reduced binding to FcγRI
– Reduced ADCC and CDC
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e4-Fc2

货号： pfc2-hg1e4      产品名称： pFUSE-hIgG1e4-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e4-Fc
pFUSE-hIgG1e4-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated E333 and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e4-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutation: E333A
Characteristics:
– Increased binding to FcγRIIIa
– Increased ADCC and CDC
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e5-Fc2

货号： pfc2-hg1e5      产品名称： pFUSE-hIgG1e5-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e5-Fc
pFUSE-hIgG1e5-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S239D/A330L/I332E and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e5-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: S239D/A330L/I332E
Characteristics:
– Increased binding to FcγRIIIa
– Increased ADCC
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e6-Fc2

货号： pfc2-hg1e6      产品名称： pFUSE-hIgG1e6-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e6-Fc
pFUSE-hIgG1e6-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated P257I/Q311I and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e5-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: P257I/Q311I
Characteristics:
– Increased binding to FcgRIIIA
– Unchanged half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e7-Fc2

货号： pfc2-hg1e7      产品名称： pFUSE-hIgG1e7-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e7-Fc
pFUSE-hIgG1e7-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated K326W/E333S and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e7-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: K326W/E333S
Characteristics:
– Increased CDC
– Increased binding to C1q
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG2e1-Fc2

货号： pfc2-hg2e1      产品名称： pFUSE-hIgG2e1-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG2e1-Fc
pFUSE-hIgG2e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG2 heavy chain mutated K322A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG2e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype : IgG2 human
Mutations: K322A
Characteristics:
– Reduced binding to C1q
– Reduced CDC
Both plasmids are selectable with Zeocin™.