pFUSE-hIgG1e3-Fc2

货号： pfc2-hg1e3      产品名称： pFUSE-hIgG1e3-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e3-Fc
pFUSE-hIgG1e3-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.  The engineered hIgG1e3 Fc contains the following mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S.
pFUSE-hIgG1e3-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
DISCLAIMER: pFUSE-hIgG1e3 plasmids featuring the IgG1e3 engineered Fc are sold by InvivoGen under a limited license from Cambridge Enterprise Limited (International Publication Number WO 99/58572).
Isotype: IgG1 human
Mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S
Characteristics:
– Reduced binding to FcγRI
– Reduced ADCC and CDC
Both plasmids are selectable with Zeocin™.