pFUSE-hIgG1e1-Fc1
货号： pfc1-hg1e1 产品名称： pFUSE-hIgG1e1-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e1-Fc
pFUSE-hIgG1e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated T250Q/M428L and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: T250Q/M428L
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.
pfc1-hg1e11 pFUSE-hIgG1e11-Fc1 品牌 Invivogen
pFUSE-hIgG1e11-Fc1
货号： pfc1-hg1e11 产品名称： pFUSE-hIgG1e11-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e11-Fc
pFUSE-hIgG1e11-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M252Y/S254T/T256E and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e11-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M252Y /S254T/T256E
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.
pfc1-hg1e12 pFUSE-hIgG1e12-Fc1 品牌 Invivogen
pFUSE-hIgG1e12-Fc1
货号： pfc1-hg1e12 产品名称： pFUSE-hIgG1e12-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e12-Fc
pFUSE-hIgG1e12-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M428L/N434A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e12-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M428L/N434A
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.
pfc1-hg1e13 pFUSE-hIgG1e13-Fc1 品牌 Invivogen
pFUSE-hIgG1e13-Fc1
货号： pfc1-hg1e13 产品名称： pFUSE-hIgG1e13-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e13-Fc
pFUSE-hIgG1e13-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated I253A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e13-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutation: I253A
Characteristics:
– Decreased binding to FcRn
– Decreased half-life (enhanced antibody clearance)
Both plasmids are selectable with Zeocin™.
pfc1-hg1e2 pFUSE-hIgG1e2-Fc1 品牌 Invivogen
pFUSE-hIgG1e2-Fc1
货号： pfc1-hg1e2 产品名称： pFUSE-hIgG1e2-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e2-Fc
pFUSE-hIgG1e2-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. The engineered hIgG1e2 Fc contains the following mutations: M252Y/S254T/T256E and H433K/N434F.
pFUSE-hIgG1e2-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M252Y/S254T/T256E + H433K/N434F
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.
pfc1-hg1e3 pFUSE-hIgG1e3-Fc1 品牌 Invivogen
pFUSE-hIgG1e3-Fc1
货号： pfc1-hg1e3 产品名称： pFUSE-hIgG1e3-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e3-Fc
pFUSE-hIgG1e3-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. The engineered hIgG1e3 Fc contains the following mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S.
pFUSE-hIgG1e3-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
DISCLAIMER: pFUSE-hIgG1e3 plasmids featuring the IgG1e3 engineered Fc are sold by InvivoGen under a limited license from Cambridge Enterprise Limited (International Publication Number WO 99/58572).
Isotype: IgG1 human
Mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S
Characteristics:
– Reduced binding to FcγRI
– Reduced ADCC and CDC
Both plasmids are selectable with Zeocin™.
pfc1-hg1e4 pFUSE-hIgG1e4-Fc1 品牌 Invivogen
pFUSE-hIgG1e4-Fc1
货号： pfc1-hg1e4 产品名称： pFUSE-hIgG1e4-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e4-Fc
pFUSE-hIgG1e4-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated E333 and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e4-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutation: E333A
Characteristics:
– Increased binding to FcγRIIIa
– Increased ADCC and CDC
Both plasmids are selectable with Zeocin™.
pfc1-hg1e5 pFUSE-hIgG1e5-Fc1 品牌 Invivogen
pFUSE-hIgG1e5-Fc1
货号： pfc1-hg1e5 产品名称： pFUSE-hIgG1e5-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e5-Fc
pFUSE-hIgG1e5-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S239D/A330L/I332E and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e5-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: S239D/A330L/I332E
Characteristics:
– Increased binding to FcγRIIIa
– Increased ADCC
Both plasmids are selectable with Zeocin™.
pfc1-hg1e6 pFUSE-hIgG1e6-Fc1 品牌 Invivogen
pFUSE-hIgG1e6-Fc1
货号： pfc1-hg1e6 产品名称： pFUSE-hIgG1e6-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e6-Fc
pFUSE-hIgG1e6-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated P257I/Q311I and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e5-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: P257I/Q311I
Characteristics:
– Increased binding to FcgRIIIA
– Unchanged half-life
Both plasmids are selectable with Zeocin™.
pfc1-hg1e7 pFUSE-hIgG1e7-Fc1 品牌 Invivogen
pFUSE-hIgG1e7-Fc1
货号： pfc1-hg1e7 产品名称： pFUSE-hIgG1e7-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e7-Fc
pFUSE-hIgG1e7-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated K326W/E333S and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e7-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: K326W/E333S
Characteristics:
– Increased CDC
– Increased binding to C1q
Both plasmids are selectable with Zeocin™.
pfc1-hg4e1 pFUSE-hIgG4e1-Fc1 品牌 Invivogen
pFUSE-hIgG4e1-Fc1
货号： pfc1-hg4e1 产品名称： pFUSE-hIgG4e1-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG4e1-Fc
pFUSE-hIgG4e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S228P and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG4e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype : IgG4 human
Mutation: S228P
Characteristics:
– Reduced Fab-arm exchange
Both plasmids are selectable with Zeocin™.
pfc1-hgin1 pINFUSE-hIgG1-Fc1 品牌 Invivogen
pINFUSE-hIgG1-Fc1
货号： pfc1-hgin1 产品名称： pINFUSE-hIgG1-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pINFUSE-hIgG1-Fc
pINFUSE-hIgG1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. A short intron is present between each region (one intron between the hinge and CH2 and one intron between CH2 and CH3). The presence of introns is known to enhance the level of gene expression as splicing is known to promote rapid and efficient mRNA export.
pINFUSE-hIgG1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted
Human IgG1 displays high ADCC and CDC, and is the most suitable for therapeutic use against pathogens and cancer cells.
Both plasmids are selectable with Zeocin™.
pfc1-hgin2 pINFUSE-hIgG2-Fc1 品牌 Invivogen
pINFUSE-hIgG2-Fc1
货号： pfc1-hgin2 产品名称： pINFUSE-hIgG2-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pINFUSE-hIgG2-Fc
pINFUSE-hIgG2-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG2 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. A short intron is present between each region (one intron between the hinge and CH2 and one intron between CH2 and CH3). The presence of introns is known to enhance the level of gene expression as splicing is known to promote rapid and efficient mRNA export.
pINFUSE-hIgG2-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted
Human IgG2 dispays low ADCC and CDC.
Both plasmids are selectable with Zeocin™.
pfc1-hgin3 pINFUSE-hIgG3-Fc1 品牌 Invivogen
pINFUSE-hIgG3-Fc1
货号： pfc1-hgin3 产品名称： pINFUSE-hIgG3-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pINFUSE-hIgG3-Fc
pINFUSE-hIgG3-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG3 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. A short intron is present between each region (one intron between the hinge and CH2 and one intron between CH2 and CH3). The presence of introns is known to enhance the level of gene expression as splicing is known to promote rapid and efficient mRNA export.
pINFUSE-hIgG3-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted
Human IgG3 displays high ADCC and CDC.
Both plasmids are selectable with Zeocin™.
pfc1-hgin4 pINFUSE-hIgG4-Fc1 品牌 Invivogen
pINFUSE-hIgG4-Fc1
货号： pfc1-hgin4 产品名称： pINFUSE-hIgG4-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pINFUSE-hIgG4-Fc
INFUSE-hIgG4-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG4 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. A short intron is present between each region (one intron between the hinge and CH2 and one intron between CH2 and CH3). The presence of introns is known to enhance the level of gene expression as splicing is known to promote rapid and efficient mRNA export.
pINFUSE-hIgG4-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted
Human IgG4 dispays low ADCC and CDC.
Both plasmids are selectable with Zeocin™.
pfc1-mg2ae1 pFUSE-mIgG2Ae1-Fc1 品牌 Invivogen
pFUSE-mIgG2Ae1-Fc1
货号： pfc1-mg2ae1 产品名称： pFUSE-mIgG2Ae1-Fc1 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-mIgG2Ae1-Fc
pFUSE-mIgG2Ae1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the murine IgG2 heavy chain mutated L235E + E318A/K320A/K322A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-mIgG2Ae1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype : IgG2a mouse
Mutations: L235E + E318A/K320A/K322A
Characteristics:
– Reduced binding to FcγRI and C1q
– Reduced ADCC and CDC
Both plasmids are selectable with Zeocin™.
pfc2-hg1e11 pFUSE-hIgG1e11-Fc2 品牌 Invivogen
pFUSE-hIgG1e11-Fc2
货号： pfc2-hg1e11 产品名称： pFUSE-hIgG1e11-Fc2 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e11-Fc
pFUSE-hIgG1e11-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M252Y/S254T/T256E and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e11-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M252Y /S254T/T256E
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.
pfc2-hg1e12 pFUSE-hIgG1e12-Fc2 品牌 Invivogen
pFUSE-hIgG1e12-Fc2
货号： pfc2-hg1e12 产品名称： pFUSE-hIgG1e12-Fc2 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e12-Fc
pFUSE-hIgG1e12-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated M428L/N434A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e12-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M428L/N434A
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.
pfc2-hg1e13 pFUSE-hIgG1e13-Fc2 品牌 Invivogen
pFUSE-hIgG1e13-Fc2
货号： pfc2-hg1e13 产品名称： pFUSE-hIgG1e13-Fc2 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e13-Fc
pFUSE-hIgG1e13-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated I253A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e13-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutation: I253A
Characteristics:
– Decreased binding to FcRn
– Decreased half-life (enhanced antibody clearance)
Both plasmids are selectable with Zeocin™.
pfc2-hg1e3 pFUSE-hIgG1e3-Fc2 品牌 Invivogen
pFUSE-hIgG1e3-Fc2
货号： pfc2-hg1e3 产品名称： pFUSE-hIgG1e3-Fc2 品牌： Invivogen 规格： 20 μg 二周到货 生化试验
pFUSE-hIgG1e3-Fc
pFUSE-hIgG1e3-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. The engineered hIgG1e3 Fc contains the following mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S.
pFUSE-hIgG1e3-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
DISCLAIMER: pFUSE-hIgG1e3 plasmids featuring the IgG1e3 engineered Fc are sold by InvivoGen under a limited license from Cambridge Enterprise Limited (International Publication Number WO 99/58572).
Isotype: IgG1 human
Mutations: E233P/L234V/L235A/ΔG236 + A327G/A330S/P331S
Characteristics:
– Reduced binding to FcγRI
– Reduced ADCC and CDC
Both plasmids are selectable with Zeocin™.