ANTI-PH-GSK3B (S9), CL 2D3

货号： 05-643      产品名称： ANTI-PH-GSK3B (S9), CL 2D3   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-phospho-GSK3β (Ser9) Antibody, clone 2D3
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REFERENCES
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.
Horacio Maldonado,Eugenio Ramírez,Elias Utreras,María E Pando,Ana M Kettlun,Mario Chiong,Ashok B Kulkarni,Lucía Collados,Javier Puente,Luis Cartier,María A Valenzuela (2011) Journal of neuroscience research.89
Measuring GSK3 expression and activity in cells.
Adam R Cole,Calum Sutherland (2008) Methods in molecular biology (Clifton, N.J.).468
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  EMSA, WB Mouse Purified Monoclonal Antibody
Description:
Anti-phospho-GSK3β (Ser9) Antibody, clone 2D3
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Trade Name:
Upstate (Millipore)
Specificity:
GSK3beta
Molecular Weight:
46kDa (GSK3β) and 51kDa (GSK3α)
Immunogen:
peptide corresponding to amino acids 6-12 (RTT[pS]AE) of human GSK3beta
Modifications:
Phosphorylation
Clone:
2D3
Isotype:
IgG1κ
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
routinely evaluated by immunoblot on L6 cells stimulated with IGF-1
Purification Method:
Thiophilic adsorption chromatography
Presentation:
100µg of thiophilic and size exclusion chromatography purified mouse IgG1κ in 100µL of antibody storage buffer (PBS with PEG, Sucrose, and 0.09% sodium azide) and 50% glycerol.
Storage Conditions:
2 years at -20°C
UniProt Number:
P49841
Entrez Gene Number:
NM_002093
Gene Symbol:
GSK3B
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Electrophoretic Mobility Shift Assay
Western Blotting
Entrez Gene Summary:
Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, 1994 [PubMed 7980435]). GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (Plyte et al., 1992 [PubMed 1333807]).[supplied by OMIM]
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UniProt Summary:
FUNCTION: SwissProt: P49841 # Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA.
SIZE: 420 amino acids; 46744 Da
SUBUNIT: Monomer (By similarity). Interacts with NIN and CABYR.
TISSUE SPECIFICITY: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.
PTM: Phosphorylated by AKT1 and ILK1.
SIMILARITY: SwissProt: P49841 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
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Brand Family:
Upstate
Product Name:
Anti-pho -20°C