pFUSE-hIgG1e9-Fc1

货号： pfc1-hg1e9      产品名称： pFUSE-hIgG1e9-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e9-Fc
pFUSE-hIgG1e9-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S239D/I332E/G236A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e9-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: S239D/I332E/G236A
Characteristics:
– Increased FcγRIIa/FcγRIIb ratio
– Increased macrophage phagocytosis
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG2e1-Fc1

货号： pfc1-hg2e1      产品名称： pFUSE-hIgG2e1-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG2e1-Fc
pFUSE-hIgG2e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG2 heavy chain mutated K322A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG2e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype : IgG2 human
Mutations: K322A
Characteristics:
– Reduced binding to C1q
– Reduced CDC
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e1-Fc2

货号： pfc2-hg1e1      产品名称： pFUSE-hIgG1e1-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e1-Fc
pFUSE-hIgG1e1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated T250Q/M428L and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: T250Q/M428L
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e2-Fc2

货号： pfc2-hg1e2      产品名称： pFUSE-hIgG1e2-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e2-Fc
pFUSE-hIgG1e2-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the mutated human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. The engineered hIgG1e2 Fc contains the following mutations: M252Y/S254T/T256E and H433K/N434F.
pFUSE-hIgG1e2-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: M252Y/S254T/T256E + H433K/N434F
Characteristics:
– Increased binding to neonatal FcR (FcRn)
– Increased half-life
Both plasmids are selectable with Zeocin™.

pFUSE-hIgG1e9-Fc2

货号： pfc2-hg1e9      产品名称： pFUSE-hIgG1e9-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-hIgG1e9-Fc
pFUSE-hIgG1e9-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain mutated S239D/I332E/G236A and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-hIgG1e9-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype: IgG1 human
Mutations: S239D/I332E/G236A
Characteristics:
– Increased FcγRIIa/FcγRIIb ratio
– Increased macrophage phagocytosis
Both plasmids are selectable with Zeocin™.