标签归档：pad

506282-10MG   PAD Inhibitor, Cl-amidine   品牌 Merck

发表于由

PAD Inhibitor, Cl-amidine

货号： 506282-10MG      产品名称： PAD Inhibitor, Cl-amidine   品牌： Merck 规格： *** 3周到货 生化实验

PAD Inhibitor, Cl-amidine
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-Orn amide
A cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 µM, 6.2 µM and 5.9 µM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays. It preferentially inactivates the calcium bound form of PAD4 in an irreversible manner, and is shown to complete with BAEE for the active site residue of this enzyme. A small but significant reduction in the efficiency of p300GDB-GRIP1 interaction is observed in transiently transfected CV-1 cells treated with Cl-amidine at concentrations between 25 µM and 200 µM, in vivo . Furthermore, this compound (200 µM) together with HDAC inhibitor SAHA (0.4 µM) has shown additive effects in inducing p21, GADD45, and PUMA expression and inhibiting cancer cell growth in a p53-dependent manner in U2OS cells.
产品信息
Form  White solid
Molar mass  424.8
Purity  >95% by HPLC
Solubility  DMSO
Chemical formula  C16H20ClF3N4O4
商店和运输信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Regulatory Review

-20°C

4426825   OPENARRAY,COMPRESSION PAD RC   品牌 Invitrogen

发表于由

OPENARRAY,COMPRESSION PAD RC

货号： 4426825      产品名称： OPENARRAY,COMPRESSION PAD RC   品牌： Invitrogen 规格： *** 三周到货 生化试验

OpenArray® Plate Compression Pad for Dual Flat Block GeneAmp® PCR System 9700
The OpenArray® Plate Compression Pad for Dual Flat Block GeneAmp® PCR System 9700 properly and evenly positions up to eight TaqMan® OpenArray® Genotyping Plates for PCR amplification. It is intended for use with the Dual Flat Block GeneAmp® PCR System 9700 System and OpenArray® Plate Adaptor for Dual Flat Block GeneAmp® PCR System 9700.
Platform: GeneAmp® 9700
Product Size: 1 pad 
Accessory Type: Compression Pad 
Plate Compatibility: OpenArray® Plates 
Shipping Condition: Room Temperature 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Required compression pad for using OpenArray® plate holder with the GeneAmp 9700 Dual flat block PCR system

10500-100   PAD4 (human recombinant)   品牌 Cayman

发表于由

PAD4 (human recombinant)

货号： 10500-100      产品名称： PAD4 (human recombinant)   品牌： Cayman 规格： 100 碌g 3周

PAD4 (human recombinant) Cayman Chemical Item Number 10500 Description Source: active recombinant N-terminal His-tagged protein expressed in E. coli · Mr: 75.8 kDa · Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. All enzymes are cytosolic except for PAD4 which is localized in the nucleus.1↗ PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A, H3, and H4, whose post-translational modifications play a large role in gene regulation.2↗ Benzoylated arginine substrates like N-α-Benzoyl-L-arginine ethyl ester (BAEE) have proven to be useful tools for characterization of PAD4, having similar kinetic properties to the natural substrates.3↗ PAD4 itself can undergo autocitrullination at several sites which inhibit its enzymatic activity and may play an important role in regulating citrullination in cells.4↗ PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that can be recognized by autoantibodies which cause the immune system to attack its own tissues.5↗ PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer’s disease, glaucoma, and cancer.2↗ Synonyms Protein Arginine Deiminase 4 Peptidylarginine Deiminase 4 Formulation 50 mM Tris, pH 7.6, containing 500 mM sodium chloride, 1 mM DTT, and 0.5 mM EDTA Purity ≥80% Stability 9 months Storage -80°C Shipping Dry ice in continental US; may vary elsewhere -80°C

10500-250   PAD4 (human recombinant)   品牌 Cayman

发表于由

PAD4 (human recombinant)

货号： 10500-250      产品名称： PAD4 (human recombinant)   品牌： Cayman 规格： 250 碌g 3周

PAD4 (human recombinant) Cayman Chemical Item Number 10500 Description Source: active recombinant N-terminal His-tagged protein expressed in E. coli · Mr: 75.8 kDa · Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. All enzymes are cytosolic except for PAD4 which is localized in the nucleus.1↗ PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A, H3, and H4, whose post-translational modifications play a large role in gene regulation.2↗ Benzoylated arginine substrates like N-α-Benzoyl-L-arginine ethyl ester (BAEE) have proven to be useful tools for characterization of PAD4, having similar kinetic properties to the natural substrates.3↗ PAD4 itself can undergo autocitrullination at several sites which inhibit its enzymatic activity and may play an important role in regulating citrullination in cells.4↗ PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that can be recognized by autoantibodies which cause the immune system to attack its own tissues.5↗ PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer’s disease, glaucoma, and cancer.2↗ Synonyms Protein Arginine Deiminase 4 Peptidylarginine Deiminase 4 Formulation 50 mM Tris, pH 7.6, containing 500 mM sodium chloride, 1 mM DTT, and 0.5 mM EDTA Purity ≥80% Stability 9 months Storage -80°C Shipping Dry ice in continental US; may vary elsewhere -80°C

10500-50   PAD4 (human recombinant)   品牌 Cayman

发表于由

PAD4 (human recombinant)

货号： 10500-50      产品名称： PAD4 (human recombinant)   品牌： Cayman 规格： 50 碌g 3周

PAD4 (human recombinant) Cayman Chemical Item Number 10500 Description Source: active recombinant N-terminal His-tagged protein expressed in E. coli · Mr: 75.8 kDa · Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. All enzymes are cytosolic except for PAD4 which is localized in the nucleus.1↗ PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones H2A, H3, and H4, whose post-translational modifications play a large role in gene regulation.2↗ Benzoylated arginine substrates like N-α-Benzoyl-L-arginine ethyl ester (BAEE) have proven to be useful tools for characterization of PAD4, having similar kinetic properties to the natural substrates.3↗ PAD4 itself can undergo autocitrullination at several sites which inhibit its enzymatic activity and may play an important role in regulating citrullination in cells.4↗ PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that can be recognized by autoantibodies which cause the immune system to attack its own tissues.5↗ PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer’s disease, glaucoma, and cancer.2↗ Synonyms Protein Arginine Deiminase 4 Peptidylarginine Deiminase 4 Formulation 50 mM Tris, pH 7.6, containing 500 mM sodium chloride, 1 mM DTT, and 0.5 mM EDTA Purity ≥80% Stability 9 months Storage -80°C Shipping Dry ice in continental US; may vary elsewhere -80°C