pUNO-hTollip

货号： puno-htollip      产品名称： pUNO-hTollip   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

Tollip
Coding sequence in expression plasmid
Toll-interacting protein
Toll-interacting protein (Tollip) was initially identified as an important constituent of the IL-1R signaling pathway[1]. Recent data suggest that this protein is also involved in TLR2 and TLR4 signaling pathways. Tollip was reported to coimmunoprecipitate with TLR2 and TLR4 and overexpression of Tollip was shown to inhibit NF-kB activation in response to TLR2 and TLR4 signaling[2]. Inhibition by Tollip is mediated through its ability to suppress the activity of IRAK[3]. Therefore, Tollip may act as moderator of the inflammatory response following TLR activation.
1. Burns K. et al.,2000. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol, 2(6):346-51
2. Bulut Y. et al., 2001. Role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol, 167(2):987-94
3. Zhang, G. and S. Ghosh, 2002. Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem, 277(9):7059-65
This gene is available in pUNO1 expression plasmid selectable with Blasticidin.
Human Tollip (pUNO1-hTollip)
ORF Size: 822bp
Subclone: AgeI – NheI
Mouse Tollip (pUNO1-mTollip)
ORF Size: 822 bp
Subclone: AgeI – NheI