pUNO-hSIGIRR

货号： puno-hsigirr      产品名称： pUNO-hSIGIRR   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

SIGIRR
Coding sequence in expression plasmid
Alias: TIR8
Single ImmunoGlobulin IL-IR-Related molecule
Single Ig IL-1R-related molecule (SIGIRR), also called TIR8, is a member of the Toll/IL-1 receptor (TIR) superfamily. SIGGIR is mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut[1]. It contains the typical conserved motifs that characterize the TIR superfamily, but is structurally and functionally distinct[2]. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice and cells from SIGIRR-deficient mice show enhanced activation in response to either IL-1 or certain TLR ligands[3]. These data suggest that SIGIRR functions as an important modulator of TLR/IL-1R signaling.
This gene is available in pUNO1 expression plasmid selectable with Blasticidin.
Human SIGIRR (pUNO1-hSIGIRR)
Genbank: NM_021805.2
ORF Size: 1233 bp
Subclone: AgeI – NheI
Mouse SIGIRR (pUNO1-mSIGIRR)
Genbank: NM_023059.3
ORF Size: 1230 bp
Subclone: AgeI – EcoRI