GABARAP, RBX-50UL

货号： AB15415      产品名称： GABARAP, RBX-50UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-GABARAP Antibody
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REFERENCES
GABAA receptor associated proteins: a key factor regulating GABAA receptor function.
Chen, Zi-Wei and Olsen, Richard W (2007) J. Neurochem., 100: 279-94 (2007)
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.
Iwata, Atsushi, et al. (2005) Proc. Natl. Acad. Sci. U.S.A., 102: 13135-40 (2005)
Lysosomal turnover of GABARAP-phospholipid conjugate is activated during differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway.
Tanida, Isei, et al. (2006) Autophagy, 2: 264-71 (2006)
Species Reactivity Key Applications Host Format Antibody Type
H, R  ICC, IHC, WB Rabbit Serum Polyclonal Antibody
Description:
Anti-GABARAP Antibody
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Trade Name:
Chemicon (Millipore)
Specificity:
GABARAP [Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein].
Immunogen:
Synthetic peptide corresponding to a region within the N-terminus of human GABARAP protein.
Background Information:
Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in modulating the activities of GABA (A) receptors.
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Species Reactivity:
Human
Rat
Application Notes:
Western blot: 1:100-1:1,000
Immunocytochemistry: 1:100-1:1,000
Immunohistochemistry: 1:100-1:1,000
Optimal working dilutions must be determined by end user.
Purification Method:
Serum
Presentation:
Lyophilized. Reconstitute with 50 uL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
Storage Conditions:
Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
UniProt Number:
O95166
Entrez Gene Number:
NM_007278.1
Gene Symbol:
GABARAP
GABA
MM46
MGC120155
MGC120154
FLJ25768
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Alternate Names:
Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunocytochemistry
Immunohistochemistry
Western Blotting
Entrez Gene Summary:
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
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Uni -20to70℃