Anti-BACH1/BRIP1 100ug

货号： 07-713      产品名称： Anti-BACH1/BRIP1 100ug   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-BACH1/BRIP1 Antibody
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REFERENCES
The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression.
Yingjie Zhang,Said Sif,Jim DeWille (2007) Journal of cellular biochemistry.102
Species Reactivity Key Applications Host Format Antibody Type
H  IP, WB Rabbit Purified Polyclonal Antibody
Description:
Anti-BACH1/BRIP1 Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
BACH1/BRIP1
Molecular Weight:
130kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 1225-1244 (KTHEIEIKNFKPSPSKNKGM) of human BACH1/BRIP1.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Protein A purfied
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q9BX63
Entrez Gene Number:
NM_032043.1
Gene Symbol:
BRIP1
FANCJ
BACH1
FLJ90232
MGC126521
OF
MGC126523
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.
UniProt Summary:
FUNCTION: SwissProt: Q9BX63 # DNA-dependent ATPase and 5′ to 3′ DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
SIZE: 1249 amino acids; 140878 Da
SUBUNIT: Binds directly to the BRCT domains of BRCA1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in testis.
PTM: Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated.
DISEASE: SwissProt: Q9BX63 # Defects in BRIP1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early- onset breast cancer. & Defects in BRIP1 are the cause of Fanconi anemia complementation group J (FANCJ) [MIM:609054, 227650]. Fanconi anemia (FA) is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
SIMILARITY: SwissProt: Q9BX63 ## Belongs to the DEAD box helicase family. DEAH subfamily. & Contains 1 helicase ATP-binding domain.
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