ANTI-Cav1.2 alpha1c

货号： AB10515      产品名称： ANTI-Cav1.2 alpha1c   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Cav1.2 alpha1c
Recommended Replacement for: AB9902
Species Reactivity Key Applications Host Format Antibody Type
M, H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Cav1.2 alpha1c Antibody
Replaces:
AB9902
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Specificity:
The antibody reacts with the 170-240 kDa Cav1.2 alpha1c protein.
Molecular Weight:
170-240 kDa
Epitope:
N-terminus
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminus region of human Cav1.2 alpha1c.
Background Information:
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Many alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
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Species Reactivity:
Mouse
Human
Species Reactivity Note:
Reacts with mouse. Other species have not been tested. 100% homology to human, 93.3% homology to (14/15aa) mouse, rat, opposum
Control:
Western Blot : Mouse Pancreas lysate.
Quality Assurance:
Western Blot Analysis: 1:1000 dilution of this antibody detected Cav1.2 alpha1c on mouse pancreas lysate.
Purification Method:
Antigen affinity purified
Presentation:
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Storage Conditions:
Store at 2-8°C for 1 year from date of receipt.
UniProt Number:
Q01815
Entrez Gene Number:
Q13936
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ‘high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart.
SUBUNIT STRUCTURE: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel act 2-8℃