TROPOMYOSIN, SM MUSC, SHX -100UL

货号： AB5437S      产品名称： TROPOMYOSIN, SM MUSC, SHX -100UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Tropomyosin Antibody, Smooth Muscle
Recommended Replacement for: AB5437
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  WB, ICC, IH(P) Sheep Serum Polyclonal Antibody
Description:
Anti-Tropomyosin Antibody, Smooth Muscle
Replaces:
AB5437
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Trade Name:
Chemicon (Millipore)
Specificity:
Recognizes Tropomyosin, smooth muscle.
Immunogen:
Synthetic peptide corresponding to the 2a exon from the α gene of tropomyosin.
Species Reactivity:
Human
Mouse
Rat
Presentation:
Liquid
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
UniProt Number:
P09493
Entrez Gene Number:
NM_000366.5
NM_001018004.1
NM_001018005.1
NM_001018006.1
NM_001018007.1
NM_001018008.1
NM_001018020.1
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Gene Symbol:
TPM1
CMH3
Tropomyosin-1
HTM-alpha
Alpha-tropomyosin
TMSA
C15orf13
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunocytochemistry
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
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UniProt Summary:
FUNCTION: SwissProt: P09493 # Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
SIZE: 284 amino acids; 32709 Da
SUBUNIT: Heterodimer of an alpha and a beta chain.
TISSUE SPECIFICITY: Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients.
DOMAIN: SwissProt: P09493 The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven- residues periodicity.
DISEASE: SwissProt: P09493 # Defects in TPM1 are the cause of familial hypertrophic cardiomyopathy type 3 (CMH3) [MIM:115196]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy [MIM:192600] is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the in -20℃