PV4169 TEK (TIE2) SINGLE PT PROFILING 品牌 Invitrogen

Anti-Tie2/TEK Antibody, clone Ab33
Close
REFERENCES
The flow dependency of Tie2 expression in endotoxemia.
Kurniati, Neng F, et al. (2013) Intensive Care Med, (2013)
Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade.
Jianzhong Huang,Jae-O Bae,Judy P Tsai,Angela Kadenhe-Chiweshe,Joey Papa,Alice Lee,Shan Zeng,Z Noah Kornfeld,Paivi Ullner,Nibal Zaghloul,Ella Ioffe,Sarah Nandor,Elena Burova,Jocelyn Holash,Gavin Thurston,John Rudge,George D Yancopoulos,Darrell J Yamashiro,Jessica J Kandel (2009) International journal of oncology.34
Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis.
Peters, K G, et al. (1998) Br. J. Cancer, 77: 51-6 (1998)
Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.
Lin, P, et al. (1998) Proc. Natl. Acad. Sci. U.S.A., 95: 8829-34 (1998)
View All
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Po WB, IP, IHC Mouse Purified Monoclonal Antibody
Description:
Anti-Tie2/TEK Antibody, clone Ab33
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes Tie2/TEK, Mr 145kDa
Molecular Weight:
145 kDa
Immunogen:
Fusion protein corresponding to residues 1-745 of human Tie2/TEK with a C-terminal His6-tag purified from infected SF-9 cells. Clone Ab33
Clone:
clone Ab33
Isotype:
IgG1κ
Background Information:
TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin-like loops separated by three epidermal growth factor-like repeats that are connected to three fibronectin type III-like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.
View All »
Species Reactivity:
Human
Mouse
Rat
Pig
Species Reactivity Note:
Human, mouse, rat, and pig.
Application Notes:
Immunoprecipitation: This antibody immunoprecipitated Tie2/TEK, as reported by an independent laboratory.
Immunohistochemistry: Reported to detect Tie2/TEK in frozen, Triton-treated sections.
This antibody is not suitable for paraffin-embedded sections.
View All »
Control:
HUVEC cell lysate
Quality Assurance:
Evaluated by western blot on RIPA lysates from HUVEC cells.
Western Blot Analysis: 0.2-1 μg/mL of this antibody detected Tie2/TEK in RIPA lysates from HUVEC cells.
Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide before the addition of glycerol to 30%. Liquid at -20°C.
Storage Conditions:
Stable for 1 year at from date of receipt.
UniProt Number:
Q02763
Entrez Gene Number:
NM_000459
Gene Symbol:
TEK
CD202B
TIE2
VMCM1
VMCM
hTIE2
CD202b
TIE-2
View All »
Alternate Names:
CD202b antigen
TEK tyrosine kinase, endothelial
Tunica interna endothelial cell kinase
Tyrosine-protein kinase receptor TEK
Tyrosine-protein kinase receptor TIE-2
p140 TEK
soluble TIE2 variant 1
soluble TIE2 variant 2venous malformations, multiple cutane -20°C