anti-phospho-PKCi (Thr555)/PKCl (Thr563)

货号： 07-881      产品名称： anti-phospho-PKCi (Thr555)/PKCl (Thr563)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-PKCι (Thr555)/PKCλ (Thr563) Antibody
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REFERENCES
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
Dhillon, Amardeep S, et al (2002) Mol Cell Biol, 22:3237-46 (2002)
Identification of the major phosphorylation sites of the Raf-1 kinase
Morrison, D K, et al (1993) J Biol Chem, 268:17309-16 (1993)
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif
Messerschmidt, Albrecht, et al (2005) J Mol Biol, 352:918-31 (2005)
Species Reactivity Key Applications Host Format Antibody Type
H, M  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-PKCι (Thr555)/PKCλ (Thr563) Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes phospho-PKCι (Thr555) and PKC&lamda; (Thr563). Can cross-react in immunoprecipitants from high expressing cells of PKCζ (Thr560).
Molecular Weight:
78 kDa
Immunogen:
Synthetic peptide corresponding to the amino acid region encompassing the human and mouse phospho-PKCι (Thr555). Sequence conserved in human PKC&lamda;.
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Mouse
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Immunoaffinity purified
Presentation:
100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
Storage Conditions:
Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P41743
Entrez Gene Number:
NM_002740.5
Gene Symbol:
PRKCI
PKCI
DXS1179E
nPKC-iota
aPKC-lambda/iota
MGC26534
PRKC-lambda/iota
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Alternate Names:
PRKCI, PKCI, nPKC-iota aPKC-lambda/iota; atypical protein kinase C-lambda/iota
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-A -20℃