anti-phospho-PKCg (Thr514)

货号： 07-878      产品名称： anti-phospho-PKCg (Thr514)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-PKCγ (Thr514) Antibody
Close
REFERENCES
Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death
Seki, Takahiro, et al (2005) J Biol Chem, 280:29096-106 (2005)
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-PKCγ (Thr514) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes phosphor-PKCγ (Thr514) and weaker with mouse and rat PKCγ. PKCα, ι, ζ, βII, ε, may cross-react in over expressig cells.
Molecular Weight:
78.5 kDa
Immunogen:
Peptide corresponding to amino acid region encompassing the human phospho-PKCγ (Thr514).
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Species Reactivity Note:
Predicted to cross-react with mouse and rat based sequence homology, but have not been tested.
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Immunoaffinity purified
Storage Conditions:
2 years at -20°C
UniProt Number:
P05129
Entrez Gene Number:
NM_002739.3
Gene Symbol:
PRKCG
SCA14
MGC57564
PKC-gamma
PKCG
PKCC
View All »
Alternate Names:
PRKCG, PKC-gamma, PKCC, PKCG, SCA14, Protein Kinase C gamma
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
View All »
UniProt Summary:
FUNCTION: SwissProt: P05129 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
SIZE: 697 amino acids; 78448 Da
SUBUNIT: Interacts with CDCP1.
DISEASE: SwissProt: P05129 # Defects in PRKCG are the cause of spinocerebellar ataxia 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (A -20℃

anti-phospho-PKCg (Thr655)

货号： 07-879      产品名称： anti-phospho-PKCg (Thr655)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-PKCγ (Thr655) Antibody
Close
REFERENCES
Mutant protein kinase Cgamma found in spinocerebellar ataxia type 14 is susceptible to aggregation and causes cell death
Seki, Takahiro, et al (2005) J Biol Chem, 280:29096-106 (2005)
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-PKCγ (Thr655) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes phosphor-PKCγ (Thr655). PKCα and PKCβII may cross react in high expressing cells.
Molecular Weight:
78.5 kDa
Immunogen:
Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-PKCγ (Thr655).
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Species Reactivity Note:
Predicted to cross-react with mouse and rat based on complete sequence homology, but have not been tested.
Purification Method:
Immunoaffinity purified
Storage Conditions:
2 years at -20°C
UniProt Number:
P05129
Entrez Gene Number:
NM_002739.3
Gene Symbol:
PRKCG
SCA14
MGC57564
PKC-gamma
PKCG
PKCC
View All »
Alternate Names:
PRKCG, PKC-gamma, PKCC, PKCG, SCA14, Protein Kinase C gamma
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
View All »
UniProt Summary:
FUNCTION: SwissProt: P05129 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
SIZE: 697 amino acids; 78448 Da
SUBUNIT: Interacts with CDCP1.
DISEASE: SwissProt: P05129 # Defects in PRKCG are the cause of spinocerebellar ataxia 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech an -20℃

anti-phospho-PKCg (Thr674)

货号： 07-880      产品名称： anti-phospho-PKCg (Thr674)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-PKCγ (Thr674) Antibody
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-PKCγ (Thr674) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes phospho-PKCγ (Thr674). May cross-react with PKCα (ser657), PKCβI (Ser661), and PKCη (Ser674) to various degrees in high expressing cells.
Molecular Weight:
78.5 kDa
Immunogen:
Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-PKCγ (Thr674).
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Species Reactivity Note:
Predicted to cross-react with Mouse and Rat based on complete sequence homology.
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Immunoaffinity purified
Storage Conditions:
2 years at -20°C
UniProt Number:
P05129
Entrez Gene Number:
NM_002739.3
Gene Symbol:
PRKCG
SCA14
MGC57564
PKC-gamma
PKCG
PKCC
View All »
Alternate Names:
PRKCG, PKC-gamma, PKCC, PKCG, SCA14, Protein Kinase C gamma
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
View All »
UniProt Summary:
FUNCTION: SwissProt: P05129 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
SIZE: 697 amino acids; 78448 Da
SUBUNIT: Interacts with CDCP1.
DISEASE: SwissProt: P05129 # Defects in PRKCG are the cause of spinocerebellar ataxia 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem -20℃