a-PAR-1B/MARK2, cl 5C12D2 100ul

货号： 05-943      产品名称： a-PAR-1B/MARK2, cl 5C12D2 100ul   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-PAR-1B/MARK2 Antibody, clone 5C12D2
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REFERENCES
Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients.
Hueso, Miguel, et al. (2004) Biochim. Biophys. Acta, 1689: 58-65 (2004)
Apical surface formation in MDCK cells: regulation by the serine/threonine kinase EMK1.
Cohen, David and Müsch, Anne (2003) Methods, 30: 269-76 (2003)
Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.
Hurov, Jonathan B, et al. (2004) Curr. Biol., 14: 736-41 (2004)
Species Reactivity Key Applications Host Format Antibody Type
H  WB Mouse Ascites Monoclonal Antibody
Description:
Anti-PAR-1B/MARK2 Antibody, clone 5C12D2
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Trade Name:
Upstate (Millipore)
Specificity:
PAR-1B/MARK2
Molecular Weight:
80 kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 288-307 (PDYKDPRRTELMVSMGYTRE) of human PAR-1B/MARK2
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot in RIPA lysates from HeLa cells
Purification Method:
Ascites
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q7KZI7
Entrez Gene Number:
NM_004954, NM_017490
Gene Symbol:
MARK2
MGC99619
EMK1
PAR-1
Alternate Names:
MARK2, microtubule affinity-regulating kinase 2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.
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UniProt Summary:
FUNCTION: SwissProt: Q7KZI7 # Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection.
COFACTOR: Magnesium.
SIZE: 788 amino acids; 87911 Da
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Note=Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane.
TISSUE SPECIFICITY: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.
SIMILARITY: SwissProt: Q7KZI7 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily. & Contains 1 KA1 (kinase- -20°C