标签： htnfa

Anti-hTNF-α-hIgG1

货号： htnfa-mab1      产品名称： Anti-hTNF-α-hIgG1   品牌： Invivogen 规格： 100 μg 二周到货 生化试验

Anti-hTNF-α-hIgG1
Neutralizing human IgG1 monoclonal antibody against human TNF-α
Anti-hTNF-α-hIgG1 is a neutralizing monoclonal antibody featuring the constant region of the human IgG1 isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α). Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Anti-hTNF-α-hIgG1 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G. The neutralizing activity of this human IgG1 antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.
Clonality: Monoclonal antibody
Application: Neutralization of human TNF-α-induced cellular activation
Specificity: Human TNF-α
Isotype: Human IgG1

 

Anti-hTNF-α-hIgG2

货号： htnfa-mab2      产品名称： Anti-hTNF-α-hIgG2   品牌： Invivogen 规格： 100 μg 二周到货 生化试验

Anti-hTNF-α-hIgG2
Neutralizing human IgG2 monoclonal antibody against human TNF-α
Anti-hTNF-α-hIgG2 is a neutralizing monoclonal antibody featuring the constant region of the human IgG2 isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α). Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Anti-hTNF-α-hIgG2 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G. The neutralizing activity of this human IgG2 antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.
Clonality: Monoclonal antibody
Application: Neutralization of human TNF-α-induced cellular activation
Specificity: Human TNF-α
Isotype: Human IgG2

Anti-hTNF-α-hIgG3

货号： htnfa-mab3      产品名称： Anti-hTNF-α-hIgG3   品牌： Invivogen 规格： 100 μg 二周到货 生化试验

Anti-hTNF-α-hIgG3
Neutralizing human IgG3 monoclonal antibody against human TNF-α
Anti-hTNF-α-hIgG3 is a neutralizing monoclonal antibody featuring the constant region of the human IgG3 isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α). Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Anti-hTNF-α-hIgG3 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G. The neutralizing activity of this human IgG3 antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.
Clonality: Monoclonal antibody
Application: Neutralization of human TNF-α-induced cellular activation
Specificity: Human TNF-α
Isotype: Human IgG3

Anti-hTNF-α-hIgG4

货号： htnfa-mab4      产品名称： Anti-hTNF-α-hIgG4   品牌： Invivogen 规格： 100 μg 二周到货 生化试验

Anti-hTNF-α-hIgG4
Neutralizing human IgG4 monoclonal antibody against human TNF-α
Anti-hTNF-α-hIgG4 is a neutralizing monoclonal antibody featuring the constant region of the human IgG4 isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α). Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Anti-hTNF-α-hIgG4 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G. The neutralizing activity of this human IgG4 antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.
ND50 (50% neutralizing dose):  ~ 2 – 5 ng/ml  for 4 ng/ml human TNF-α in HEK-Blue™ TNF-α/IL-1β cells
Clonality: Monoclonal antibody
Application: Neutralization of human TNF-α-induced cellular activation
Specificity: Human TNF-α
Isotype: Human IgG4
Formulation: 0.2 µm filtered solution in 75 mM phosphate buffer with 100 mM glycine, 5% w/v saccharose and stabilizing agents