标签： hige

hcd20-mab8   Anti-hCD20-hIgE   品牌 Invivogen

Anti-hCD20-hIgE

货号： hcd20-mab8      产品名称： Anti-hCD20-hIgE   品牌： Invivogen 规格： 100 μg 二周到货 生化试验

Anti-hCD20-hIgE
Monoclonal human IgE antibody against human CD20
Anti-hCD20-hIgE features the constant region of the human IgE isotype and the variable region of rituximab. Rituximab is a mouse/human chimeric monoclonal antibody that targets the CD20 antigen found on the surface of malignant and normal B lymphocytes. Binding of rituximab to CD20 results in cell destruction through different mechanisms including direct signaling of apoptosis, complement activation and cell-mediated cytotoxicity. Rituximab has been approved by the FDA for the treatment of various lymphoid malignancies, including B-cell non-Hodgkin’s lymphoma and B-cell chronic lymphocytic leukaemia. Anti-hCD20-hIgE was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein L.
Clonality: Monoclonal antibody
Specificity: Targets cells expressing human CD20
Isotype: Human IgE

htnfa-mab8   Anti-hTNF-α-hIgE   品牌 Invivogen

Anti-hTNF-α-hIgE

货号： htnfa-mab8      产品名称： Anti-hTNF-α-hIgE   品牌： Invivogen 规格： 100 μg 二周到货 生化试验

Anti-hTNF-α-hIgE
Neutralizing human IgE monoclonal antibody against human TNF-α
Anti-hTNF-α-hIgE is a neutralizing monoclonal antibody featuring the constant region of the human IgE isotype and the variable region of adalimumab. Adalimumab is a fully human monoclonal antibody against the pro-inflammatory cytokine human tumor necrosis factor alpha (hTNF-α). Adalimumab binds to TNF-α and blocks its interaction with TNF receptors thereby downregulating the inflammatory reactions associated with autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Anti-hTNF-α-hIgE was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein L. The neutralizing activity of this human IgE antibody was determined using HEK-Blue™ TNF-α/IL-1β cells.
Clonality: Monoclonal antibody
Application: Neutralization of human TNF-α-induced cellular activation
Specificity: Human TNF-α
Isotype: Human IgE