标签归档：hrp

puno-hrp105   pUNO-hRP105   品牌 Invivogen

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pUNO-hRP105

货号： puno-hrp105      产品名称： pUNO-hRP105   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

RP105
Coding sequence in expression plasmid
Alias: CD180, Ly78, Ly64
RP105 (CD180)
RP105, a TLR-related protein, was identified in B cells and acts as both an LPS sensor and a regulator of B cell proliferation1. B-cells lacking RP105 were shown to be severely impaired in LPS-induced proliferation and antibody production. Like TLR4, RP105 requires a MD2-related protein, MD1, for its surface expression. Furthermore, the expression of RP105 was reported to strongly increase during differentiation, suggesting that RP105 is also important in monocyte function2.
1. Miyake K. et al., 2000. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1. J Endotoxin Res, 6(5):389-91
2. Zarember A. and PJ. Godowski, 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol, 168(2):554-61
This gene is available in pUNO1 expression plasmid selectable with Blasticidin.
Human RP105 (pUNO1-hRP105)
ORF Size: 1983bp
Subclone: NcoI – NheI
Mouse RP105 (pUNO1-mRP105)
ORF Size: 1983bp
Subclone: NcoI – NheI