标签归档：conjugate

AB2290B   Anti-MAP-2, Biotin Conjugate   品牌 Millipore

发表于由

Anti-MAP-2, Biotin Conjugate

货号： AB2290B      产品名称： Anti-MAP-2, Biotin Conjugate   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-MAP-2, Biotin Conjugate
Species Reactivity Key Applications Host Format Antibody Type
R, M  IHC Rabbit Biotin null
Description:
Anti-MAP-2 Antibody, Biotin Conjugate | AB2290B
Promotional Text:
Special Offer on Antibodies! Click Here!
Molecular Weight:
The unconjugated parent antibody (Cat. No. AB2290) has an observed molecular weight at ~260 kDa.
Immunogen:
KLH-conjugated linear peptide corresponding to rat MAP-2.
Background Information:
The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. (Herzog and Weber, 1978). MAP-2 is essential for the development and maitenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.
View All »
Species Reactivity:
Rat
Mouse
Species Reactivity Note:
Demonstrated to react with Rat and Mouse.
Application Notes:
Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected MAP-2 in paraffin sections of adult mouse brain tissue.
Control:
Adult mouse brain tissue
Quality Assurance:
Evaluated by Immunohistochemistry in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MAP-2 in cryosections of adult mouse brain tissue.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA..
Storage Conditions:
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
UniProt Number:
P15146
Entrez Gene Number:
NP_037198
Gene Symbol:
Map2
Mtap2
Alternate Names:
Microtubule-associated protein 2
MAP-2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunohistochemistry
Entrez Gene Summary:
Regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities [RGD].
UniProt Summary:
FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton Probable.
DEVELOPMENTAL STAGE: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. MAP2A/c is phosphorylated.
SEQUENCE SIMILARITIES: Con 2-8℃

AB2290C3   Anti-MAP2, Cy3 Conjugate   品牌 Millipore

发表于由

Anti-MAP2, Cy3 Conjugate

货号： AB2290C3      产品名称： Anti-MAP2, Cy3 Conjugate   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-MAP2, Cy3 Conjugate
Close
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Species Reactivity Key Applications Host Format Antibody Type
R, M  ICC Rabbit Cy3 Polyclonal Antibody
Description:
Anti-MAP2, Cy3 Conjugate Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Molecular Weight:
The unconjugated parent antibody (Cat. No. AB2290) has an observed molecular weight at ~260 kDa.
Immunogen:
Three KLH-conjugated linear peptides corresponding to the N-terminal and central regions of rat MAP-2.
Background Information:
The microtubule-associated protein 2 (MAP-2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. (Herzog and Weber, 1978). MAP-2 is essential for the development and maitenance of neuronal morphology (Matus, 1991). Three primary isoforms of MAP-2, the high molecular weight MAP2a and MAP2b, and the low molecular weight MAP2c (resulting from alternate splicing of the MAP2 gene), have been identified in neurours. (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP-2 together with MAP-4 and tau proteins belong to the family of thermostable proteins associated with microtubules.
View All »
Species Reactivity:
Rat
Mouse
Species Reactivity Note:
Demonstrated to react with Rat. Predicted to react with Mouse based on 100% sequence homology.
Control:
Rat E18 primary cortex cells
Quality Assurance:
Evaluated by Immunocytochemistry in rat E18 primary cortex cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected MAP-2 in rat E18 primary cortex cells.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal conjugated to Cy3 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P15146
Entrez Gene Number:
NP_037198
Gene Symbol:
Map2
Mtap2
Alternate Names:
Microtubule-associated protein 2
MAP-2
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunocytochemistry
Entrez Gene Summary:
Regulates and organizes microtubules; may serve as a scaffolding protein for neuromodulatory activities [RGD].
UniProt Summary:
FUNCTION: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton Probable.
DEVELOPMENTAL STAGE: Isoform MAP2C is expressed during embryonic brain development and until postanatal day 10. Isoform MAP2B is expressed throughout brain development.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR By similarity. MAP2A/c is phosphorylated.
SEQUENCE SIMILARITIES: Contains 4 Tau/MAP repeats.
Vie 2-8℃

12-539   ABLTIDE, BIOTIN CONJUGATE 500UG   品牌 Millipore

发表于由

ABLTIDE, BIOTIN CONJUGATE 500UG

货号： 12-539      产品名称： ABLTIDE, BIOTIN CONJUGATE 500UG   品牌： Millipore 规格： EA 三周到货 生化实验

Abltide, biotin conjugate
Close
PRODUCT FAMILY INFORMATION
Kinase & Phosphatase Products
Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
Millipore has a broad and continuously expanding portfolio of recombinant proteins. This portfolio includes more than 350 active, inactive and unactivated kinases, phosphatases and the largest available selection of disease relevant mutants. All of our enzymes are available in quantities sufficient for routine testing, as well as high throughput screening.
» More…
Description:
Abltide, biotin conjugate
Trade Name:
Upstate (Millipore)
Qty/Pk:
500 µg
Product Overview:
Description: Synthetic peptide (EAIYAAPFAKKK), biotinylated at the C-terminus.
Applications:
Abltide, biotin conjugate primarily used in Kinase Assays.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Entrez Gene Summary:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
View All »
UniProt Summary:
FUNCTION: SwissProt: P00519 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
COFACTOR: Magnesium or manganese.
SIZE: 1130 amino acids; 122873 Da
SUBUNIT: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.
TISSUE SPECIFICITY: Widely expressed.
PTM: Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation. Isoform IB is myristoylated on Gly-2.
DISEASE: SwissProt: P00519 # A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
SIMILARITY: SwissProt: P00519 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
View All »