Amyloid Beta Precursor Proteins Trial Pack

货号： 15-205      产品名称： Amyloid Beta Precursor Proteins Trial Pack   品牌： Millipore 规格： EA 三周到货 生化实验

Amyloid Beta Precursor Proteins Explorer Antibody MiniPack
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Description:
Amyloid Beta Precursor Proteins Explorer Antibody MiniPack
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Background Information:
Pathway Explorer Antibody MiniPack:
Each Pathway Explorer Antibody Minipack contains three related antibodies as part of a signaling cascade or a combination of total and phosphorylated forms of key signaling targets. Each of the three antibodies are 30% the original pack size. Full size versions of each of the Pathway Explorer antibodies are available for sale individually under the same catalog number with the removal of “SP” off of each one (e.g. 05-591SP can be ordered as 05-591).
Alzheimer Precursor Protein A4, clone 22C11:
Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humand and cases of Alzheimer’s Disease. The principle component of this extracellular amyloid is beta/A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins are currently under investigation.
* see full size version for corresponding references.
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Presentation:
3 individual tubes containing either Anti-Amyloid Precursor Protein, C-terminus; Anti-Alzheimer Precursor Protein, APP 643-695 C-terminal fragment, Clone 2.F2.19B4; or Anti-Alzheimer Precursor Protein A4, clone 22C11
UniProt Number:
P05067
Entrez Gene Number:
NM_000484.2
NM_201413.1
NM_201414.1
Gene Symbol:
APP
PN-II
AD1
ABETA
CTFgamma
APPI
ABPP
A4
CVAP
PN2
PreA4
AAA
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Components:
MAB348SP Anti-Alzheimer Precursor Protein A4, clone 22C11: 15 μg
MAB343SP Anti-Alzheimer Precursor Protein, APP 643-695 C-terminal fragment, Clone 2.F2.19B4; 30 μL
AB5352SP Anti-Amyloid Precursor Protein, C-terminus; 30 μL
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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UniProt Summary:
FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity.
FUNCTION: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 -20℃