标签归档：cadherin

205615-10MG   E-Cadherin Upregulator, ResEcad   品牌 Merck

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E-Cadherin Upregulator, ResEcad

货号： 205615-10MG      产品名称： E-Cadherin Upregulator, ResEcad   品牌： Merck 规格： *** 3周到货 生化实验

E-Cadherin Upregulator, ResEcad
5-(Furan-2-yl)-N-(pyridine-4-yl)butyl)isoxazole-3-carboxamide, E-Cadherin Expression Restorer
A cell-permeable isoxazolocarboxamide compound that enhances the E-cadherin protein level in lung squamous cell carcinoma H520 and colorectal adenocarcinoma SW620 cells (6.3- and 10-fold, respectively; 10 µM for 24 h) in a dose-dependent manner (EC50 = 1.25 and 2.13 µM, respectively), resulting in an effective culture invasiveness reduction (by ~50% in SW620 invasion assays). The observed cellular E-cadherin protein upregulation correlates well with an increase in both cellular E-cadherin gene CHD1 transcription (10.2-fold increase in SW620 by RNA-Seq analysis;10 µM for 24 h) and histone H4 Lys9 acetylation (19- and 57-fold enhancement in H529 and SW620 cells, respectively; 10 µM for 24 h), although evidence indicates no direct inhibition of HDACs 1-11 activity by the compound and other cellular factors involved in histone acetylation regulation are the likely candidates as the direct drug target(s).
产品信息
Form  Off-white powder
Molar mass  311.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C17H17N3O3
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review

2°C – 8°C