A HU BTK 200UL

货号： 05-415      产品名称： A HU BTK 200UL   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-BTK Antibody
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REFERENCES
Bruton’s tyrosine kinase is not essential for Bcr-Abl-mediated transformation of lymphoid or myeloid cells.
M MacPartlin,A M Smith,B J Druker,L A Honigberg,M W Deininger (2008) Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K.22
Discordant phenotype in siblings with X-linked agammaglobulinemia.
Bykowsky, M J, et al. (1996) Am. J. Hum. Genet., 58: 477-83 (1996)
Activation of Bruton’s tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.
Li, T, et al. (1995) Immunity, 2: 451-60 (1995)
Generation and characterization of subtype-specific monoclonal antibodies to K+ channel alpha- and beta-subunit polypeptides.
Bekele-Arcuri, Z, et al. (1996) Neuropharmacology, 35: 851-65 (1996)
Species Reactivity Key Applications Host Format Antibody Type
H  IP, WB Mouse Ascites Monoclonal Antibody
Description:
Anti-BTK Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
BTK
Molecular Weight:
77kDa
Immunogen:
Partial fusion protein corresponding to residues 1-175 of human BTK; clone 10D11
Isotype:
IgG1
Species Reactivity:
Human
Application Notes:
Not recommended for IPK or ICC.
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from Raji cells
Purification Method:
Ascites
Presentation:
mouse ascites containing 0.02% sodium azide
Storage Conditions:
2 years at -20°C
UniProt Number:
Q06187
Entrez Gene Number:
NM_000061
Gene Symbol:
BTK
MGC126261
ATK
XLA
AT
PSCTK1
IMD1
OTTHUMP00000063593
BPK
AGMX1
MGC126262
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
Defects in the Bruton tyrosine kinase (BTK) gene cause Agammaglobulinemia. Agammaglobulinemia is an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement.
UniProt Summary:
FUNCTION: SwissProt: Q06187 # Plays a crucial role in B-cell ontogeny. Transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Required for the formation of functional ARID3A DNA-binding complexes.
COFACTOR: Binds 1 zinc ion per subunit.
SIZE: 659 amino acids; 76281 Da
SUBUNIT: Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with GTF2I and ARID3A.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity).
PTM: Autophosphorylated on Tyr-223 and Tyr-551. Phosphorylation of Tyr-223 may create a docking site for a SH2 containing protein (By similarity).
DISEASE: SwissProt: Q06187 # Defects in BTK are the cause of X-linked agammaglobulinemia type 1 (XLA) [MIM:300300]. XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marro -20°C