anti-phospho-Rsk1(Thr359/Ser363),Rb mono
货号: 04-419 产品名称: anti-phospho-Rsk1(Thr359/Ser363),Rb mono 品牌: Millipore 规格: EA 3周到货 生化实验
Anti-phospho-Rsk1 (Thr359/Ser363) Antibody, rabbit monoclonal
Species Reactivity Key Applications Host Format Antibody Type
H, M ICC, IH(P), IP, WB Rabbit Unpurified Monoclonal Antibody
Description:
Anti-phospho-Rsk1 (Thr359/Ser363) Antibody, rabbit monoclonal
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the RSK-1 when phosphorylated on Thr359 and Ser363.
Molecular Weight:
90 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to the residues surrounding Thr359 and Ser363 of human RSK-1 (p90-Rsk-1).
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Mouse
Species Reactivity Note:
Not expected to react with Rat.
Quality Assurance:
Routinely evaluated by immunoblot.
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q15418
Entrez Gene Number:
NM_001006665.1
NM_002953.3
Gene Symbol:
RPS6KA1
HU-1
RSK-1
MAPKAPK1A
RSK
pp90RSK1
p90S6K
RSK1
Alternate Names:
RPS6KA1, ribosomal protein S6 kinase, 90kDa, polypeptide 1, MAPKAPK1A, RSK, RSK1, S6K-alpha 1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Immunocytochemistry
Immunohistochemistry (Paraffin)
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniProt Summary:
FUNCTION: SwissProt: Q15418 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium.
SIZE: 735 amino acids; 82723 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.
PTM: Autophosphorylated on Ser-380, as part of the activation process.
SIMILARITY: SwissProt: Q15418 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
Brand Family:
Upstate
Product Name:
Anti-phospho-Rsk1 (Thr359/Ser363) Antibody, rabbit monoclonal
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Unpurified
Host:
Rabbit
Applications:
Anti-phospho-Rsk1 (Thr359/Ser363) Antibody, rabbit is an antibody against phospho-Rsk1 (Thr359/Ser363) for use in IC, IH(P), IP & WB.
-20°C
10008639-1 FTY720 Phosphate 品牌 Cayman
FTY720 Phosphate
货号: 10008639-1 产品名称: FTY720 Phosphate 品牌: Cayman 规格: 1 mg 3周
FTY720 Phosphate
Cayman Chemical Item Number 10008639
Description
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.2↗,3↗ FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.2↗,3↗,4↗
Synonyms FTY720P
Formal Name 2-amino-2[2-(4-octylphenyl)ethyl]-1,3-propanediol, mono dihydrogen phosphate ester
CAS Number 402615-91-2
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCC1=CC=C(CCC([NH3+])(COP([O-])(O)=O)CO)C=C1
InCHI Code 1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)
InCHI Key LRFKWQGGENFBFO-UHFFFAOYSA-N
-20°C
OSC00006Y Olfactory Marker Protein 品牌 Pierce
Olfactory Marker Protein
货号: OSC00006Y 产品名称: Olfactory Marker Protein 品牌: Pierce 规格: 500 μg
1539-1 β-Pompilidotoxin 品牌 Tocris
β-Pompilidotoxin
货号: 1539-1 产品名称: β-Pompilidotoxin 品牌: Tocris 规格: 1 mg
4414083 HUMAN ANDROGEN 品牌 Invitrogen
HUMAN ANDROGEN
货号: 4414083 产品名称: HUMAN ANDROGEN 品牌: Invitrogen 规格: EACH 三周到货 生化试验
TaqMan® Array Human Androgens
The Applied Biosystems® TaqMan® Array Human Androgens 96-well Plate contains 92 assays to androgen associated genes and 4 assays to candidate endogenous control genes.
The panel of assays in the TaqMan® Array Human Androgens 96-well Plate targets genes which code for enzymes involved in androgen synthesis, regulators of androgen production, and receptors and signal transduction proteins which mediate their effects, and targets of androgen signaling. The panel also includes the Y-chromosome SRY genes, which play roles in male phenotype development, as well as differentiation of the bipotential gonad into testes. Several genes associated with the estrogen pathway are also included on the panel, as androgens are precursors for estrogens and they play many functionally related roles. Gene Signature Plates are 96-well plates that are pre-configured with the most appropriate TaqMan® Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains
Form: Dried Down
Format: 96-well plate
Species: Human
Label or Dye: FAM™
Product Size: 1 standard plate
Purification: Standard
Reaction Speed: Standard
Research Category: Signal Transduction,
Biomarker-Related Pathway(s),
Oncology,
Endocrinology
Internal Probe Modification: Non-Fluorescent Quencher (3′),
MGB (Minor Groove Binder) (3′),
FAM (5′)
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array Plate well contains a single TaqMan® Assay for one 20 µL reaction. The plates can be stored at room temperature or at 4°C.
O9322-25 g Oxfendazole 品牌 LKT
Oxfendazole
货号: O9322-25 g 产品名称: Oxfendazole 品牌: LKT 规格: 25 g 三周到货 生化试验
Oxfendazole
Description
An anthelmintic agent.
Specifications
Cas No. 53716-50-0
Product ID O9322
Product Name Oxfendazole
Chemical Name [5-(Phenylsulfinyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester
Synonym Repidose; Systamex
Formula Wt. 315.35
Melting Point 253oC (dec)
Purity ≥98%
Solubility Insoluble in water. Slightly soluble in acetone, chloroform, ether and methanol.
Store Temp Ambient
References Corwin RM. Am J Vet Res. 38:465-7 (1977).
室温
MSVEGFR3-MAG 77-anti Soluble VEGF R3 Magnetic Beads 品牌 Millipore
77-anti Soluble VEGF R3 Magnetic Beads
货号: MSVEGFR3-MAG 产品名称: 77-anti Soluble VEGF R3 Magnetic Beads 品牌: Millipore 规格: EA
PR040 MPG Buffer 100ml 品牌 Omega
MPG Buffer 100ml
货号: PR040 产品名称: MPG Buffer 100ml 品牌: Omega 规格: ***
ADI-SPA-960-E HSF2, mAb (3E2) 品牌 Enzo
HSF2, mAb (3E2)
货号: ADI-SPA-960-E 产品名称: HSF2, mAb (3E2) 品牌: Enzo 规格: 100 ug
JBS-CLK-RP-3402-100 2′-O-Propargyl Cytidine, 100 mg pack 品牌 AXXORA
2′-O-Propargyl Cytidine, 100 mg pack
货号: JBS-CLK-RP-3402-100 产品名称: 2′-O-Propargyl Cytidine, 100 mg pack 品牌: AXXORA 规格: 100 mg
636602 Mouse Heart Total RNA 品牌 clontech
Mouse Heart Total RNA
货号: 636602 产品名称: Mouse Heart Total RNA 品牌: clontech 规格: 250 μg
OSC00007W c-Fos 品牌 Pierce
c-Fos
货号: OSC00007W 产品名称: c-Fos 品牌: Pierce 规格: 100 μl
04-419-K Anti-phospho-Rsk1(Thr359/Ser363) -ML 品牌 Millipore
Anti-phospho-Rsk1(Thr359/Ser363) -ML
货号: 04-419-K 产品名称: Anti-phospho-Rsk1(Thr359/Ser363) -ML 品牌: Millipore 规格: ML 三周到货 生化实验
Anti-phospho-Rsk1 (Thr359/Ser363) Antibody, rabbit monoclonal
Close
REFERENCES
A plate-based assay to measure cellular ERK substrate phosphorylation: utility for drug discovery of the MAPK-signaling cascade.
Sreemathy Ramaswamy,Ivana Yen,Steve Sideris,Shiva Malek,Christopher E Heise (2010) Assay and drug development technologies.8
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity
Roux, Philippe P, et al (2003) Mol Cell Biol, 23:4796-804 (2003)
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
Saitoh, Masao, et al (2002) J Biol Chem, 277:20104-12 (2002)
Species Reactivity Key Applications Host Format Antibody Type
H, M ICC, IH(P), IP, WB Rabbit Unpurified Monoclonal Antibody
Description:
Anti-phospho-Rsk1 (Thr359/Ser363) Antibody, rabbit monoclonal
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the RSK-1 when phosphorylated on Thr359 and Ser363.
Molecular Weight:
90 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to the residues surrounding Thr359 and Ser363 of human RSK-1 (p90-Rsk-1).
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Mouse
Species Reactivity Note:
Not expected to react with Rat.
Quality Assurance:
Routinely evaluated by immunoblot.
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q15418
Entrez Gene Number:
NM_001006665.1
NM_002953.3
Gene Symbol:
RPS6KA1
HU-1
RSK-1
MAPKAPK1A
RSK
pp90RSK1
p90S6K
RSK1
View All »
Alternate Names:
RPS6KA1, ribosomal protein S6 kinase, 90kDa, polypeptide 1, MAPKAPK1A, RSK, RSK1, S6K-alpha 1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunocytochemistry
Immunohistochemistry (Paraffin)
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
View All »
UniProt Summary:
FUNCTION: SwissProt: Q15418 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium.
SIZE: 735 amino acids; 82723 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.
PTM: Autophosphorylated on Ser-380, as part of the activation process.
SIMILARITY: SwissProt: Q15418 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
Vie -20℃
4414084 HUMAN CHEMOKINE 品牌 Invitrogen
HUMAN CHEMOKINE
货号: 4414084 产品名称: HUMAN CHEMOKINE 品牌: Invitrogen 规格: EACH 三周到货 生化试验
TaqMan® Array Human Chemokines
The panel of assays in this plate targets genes from each of the four classes of chemokines:
■CC Chemokines,
■CXC Chemokines,
■C Chemokines, and
■CX3C Chemokines. Other chemokine related genes, including chemokine ligands and receptors, are also included in this panel.
Gene Signature Plates are 96-well plates that are pre-configured with the most appropriate Applied Biosystems® TaqMan® Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains predefined assays and endogenous controls dried-down in the wells, ready for accurate assessment of an entire gene signature in one simple experiment.
• Affordable; minimum order of three plates; ideal for small, medium or large-sized projects
• Fast delivery; on your bench in days
• Convenient; dried PCR primer and TaqMan® probe sets supplied in a 96- well plate; just add master mix and your sample
• Same TaqMan®Assay Quality, New Format
Form: Dried Down
Format: 96-well plate
Species: Human
Label or Dye: FAM™
Product Size: 1 standard plate
Purification: Standard
Reaction Speed: Standard
Research Category: Oncology,
Neurobiology,
Immunology,
Development,
Extracellular Matrix & Cell Adhesion,
Cell Cycle & Proliferation,
Biomarker-Related Pathway(s),
Apoptosis,
Signal Transduction
Internal Probe Modification: Non-Fluorescent Quencher (3′),
MGB (Minor Groove Binder) (3′),
FAM (5′)
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array Plate well contains a single TaqMan® Assay for one 20 µL reaction. The plates can be stored at room temperature or at 4°C.
10008639-10 FTY720 Phosphate 品牌 Cayman
FTY720 Phosphate
货号: 10008639-10 产品名称: FTY720 Phosphate 品牌: Cayman 规格: 10 mg 3周
FTY720 Phosphate
Cayman Chemical Item Number 10008639
Description
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.2↗,3↗ FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.2↗,3↗,4↗
Synonyms FTY720P
Formal Name 2-amino-2[2-(4-octylphenyl)ethyl]-1,3-propanediol, mono dihydrogen phosphate ester
CAS Number 402615-91-2
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCC1=CC=C(CCC([NH3+])(COP([O-])(O)=O)CO)C=C1
InCHI Code 1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)
InCHI Key LRFKWQGGENFBFO-UHFFFAOYSA-N
-20°C
1540-10 DCPIB 品牌 Tocris
DCPIB
货号: 1540-10 产品名称: DCPIB 品牌: Tocris 规格: 10 mg
PR041 RCB Buffer 100ml 品牌 Omega
RCB Buffer 100ml
货号: PR041 产品名称: RCB Buffer 100ml 品牌: Omega 规格: ***
O9334-10 g Oxibendazole 品牌 LKT
Oxibendazole
货号: O9334-10 g 产品名称: Oxibendazole 品牌: LKT 规格: 10 g 三周到货 生化试验
Oxibendazole
Description
An anthelmintic agent. It has been shown to be effective in killing Trichinella spiralis in mice, and histotrophic larvea and adult parasites in calves.
Specifications
Cas No. 20559-55-1
Product ID O9334
Product Name Oxibendazole
Chemical Name (5-propoxy-1H-benzimidazol-2-yl) carbamic acid methyl ester
Synonym Equitac; SKF-30310; Anthelcide EQ
Formula Wt. 249.27
Melting Point 230oC-230.5oC
Purity ≥98%
Solubility Insoluble in water. Soluble in acetic acid and formic acid.
Store Temp Ambient
References Karunakaran CS, Denham DA. J Parasitol. 66:929-32 (1980). Theodorides VJ, DiCuollo CJ, Nawalinski T et al. Am J Vet Res. 38:809-14 (1977).
室温
MT17MAG47K-PX25 Mouse Th17 Premixed 25 Plex MAG Kit 品牌 Millipore
Mouse Th17 Premixed 25 Plex MAG Kit
货号: MT17MAG47K-PX25 产品名称: Mouse Th17 Premixed 25 Plex MAG Kit 品牌: Millipore 规格: EA
ADI-SPA-970-0050 TRAP1, pAb 品牌 Enzo
TRAP1, pAb
货号: ADI-SPA-970-0050 产品名称: TRAP1, pAb 品牌: Enzo 规格: 50 ug