FTY720 Phosphate

货号： 10008639-10      产品名称： FTY720 Phosphate   品牌： Cayman 规格： 10 mg 3周

FTY720 Phosphate
Cayman Chemical Item Number 10008639
Description
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.2↗,3↗ FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.2↗,3↗,4↗
Synonyms FTY720P
Formal Name 2-​amino-​2[2-​(4-​octylphenyl)ethyl]-​1,​3-​propanediol,​ mono dihydrogen phosphate ester
CAS Number 402615-91-2
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCC1=CC=C(CCC([NH3+]​)​(COP([O-]​)​(O)​=O)​CO)​C=C1 
InCHI Code 1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)​13-14-19(20,15-21)​16-25-26(22,23)​24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)​
InCHI Key LRFKWQGGENFBFO-UHFFFAOYSA-N

-20°C

FTY720 Phosphate

货号： 10008639-25      产品名称： FTY720 Phosphate   品牌： Cayman 规格： 25 mg 3周

FTY720 Phosphate
Cayman Chemical Item Number 10008639
Description
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.2↗,3↗ FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.2↗,3↗,4↗
Synonyms FTY720P
Formal Name 2-​amino-​2[2-​(4-​octylphenyl)ethyl]-​1,​3-​propanediol,​ mono dihydrogen phosphate ester
CAS Number 402615-91-2
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCC1=CC=C(CCC([NH3+]​)​(COP([O-]​)​(O)​=O)​CO)​C=C1 
InCHI Code 1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)​13-14-19(20,15-21)​16-25-26(22,23)​24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)​
InCHI Key LRFKWQGGENFBFO-UHFFFAOYSA-N

-20°C

FTY720 (S)-Phosphate

货号： 10006408-10      产品名称： FTY720 (S)-Phosphate   品牌： Cayman 规格： 10 mg 3周

FTY720 (S)-Phosphate
Cayman Chemical Item Number 10006408
Description
FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗ FTY720 is phosphorylated by sphingosine kinases in vivo, and then acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors.2↗ FTY720 (S)-phosphate is the single stereoisomer formed by phosphorylation of FTY720 in vivo, as determined in rats and humans.3↗ It exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, whereas the R enantiomer binds with 5 to 130-fold lower affinity.4↗ FTY720 (S)-phosphate causes internalization of S1P1 on lymphocytes, abrogating S1P-dependent egress of lymphocytes from lymphoid organs.5↗ It also enhances endothelial barrier function,5↗ stimulates the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc16↗ and inhibits cytosolic phospholipase A2 activity.7↗
Synonyms (S)-FTY 720P
Formal Name (2S)-​amino-​2-​[2-​(4-​octylphenyl)ethyl]-​1-​(dihydrogen phosphate)-​1,​3-​propanediol
CAS Number 402616-26-6
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCCc1ccc(cc1)​CC[C@]​(N)​(CO)​COP(=O)​(O)​O 
InCHI Code ​1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)​13-14-19(20,15-21)​16-25-26(22,23)​24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)​/t19-/m0/s1 
InCHI Key LRFKWQGGENFBFO-IBGZPJMESA-N

-20°C

FTY720 (S)-Phosphate

货号： 10006408-500      产品名称： FTY720 (S)-Phosphate   品牌： Cayman 规格： 500 碌g 3周

FTY720 (S)-Phosphate
Cayman Chemical Item Number 10006408
Description
FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗ FTY720 is phosphorylated by sphingosine kinases in vivo, and then acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors.2↗ FTY720 (S)-phosphate is the single stereoisomer formed by phosphorylation of FTY720 in vivo, as determined in rats and humans.3↗ It exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, whereas the R enantiomer binds with 5 to 130-fold lower affinity.4↗ FTY720 (S)-phosphate causes internalization of S1P1 on lymphocytes, abrogating S1P-dependent egress of lymphocytes from lymphoid organs.5↗ It also enhances endothelial barrier function,5↗ stimulates the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc16↗ and inhibits cytosolic phospholipase A2 activity.7↗
Synonyms (S)-FTY 720P
Formal Name (2S)-​amino-​2-​[2-​(4-​octylphenyl)ethyl]-​1-​(dihydrogen phosphate)-​1,​3-​propanediol
CAS Number 402616-26-6
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCCc1ccc(cc1)​CC[C@]​(N)​(CO)​COP(=O)​(O)​O 
InCHI Code ​1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)​13-14-19(20,15-21)​16-25-26(22,23)​24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)​/t19-/m0/s1 
InCHI Key LRFKWQGGENFBFO-IBGZPJMESA-N

-20°C

FTY720 (R)-Phosphate

货号： 10006407-10      产品名称： FTY720 (R)-Phosphate   品牌： Cayman 规格： 10 mg 3周

FTY720 (R)-PhosphateExclusive
Cayman Chemical Item Number 10006407
Description FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗ FTY720 is phosphorylated by sphingosine kinases in vivo, and then acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors.2↗ FTY720 (R)-phosphate is one of the stereoisomers of FTY720-phosphate, but it is apparently not formed in vivo.3↗ FTY720 (S)-phosphate exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1-5, respectively, whereas the R isomer binds with 5 to 130-fold lower affinity.4↗
Formal Name (2R)-​amino-​2-​[2-​(4-​octylphenyl)ethyl]-​1-​(dihydrogen phosphate)-​1,​3-​propanediol
CAS Number 402616-23-3
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCCc1ccc(cc1)​CC[C@@]​(N)​(CO)​COP(=O)​(O)​O 
InCHI Code  ​1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)​13-14-19(20,15-21)​16-25-26(22,23)​24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)​/t19-/m1/s1 
InCHI Key LRFKWQGGENFBFO-LJQANCHMSA-N

-20°C