FTY720 Phosphate

货号： 10008639-1      产品名称： FTY720 Phosphate   品牌： Cayman 规格： 1 mg 3周

FTY720 Phosphate
Cayman Chemical Item Number 10008639
Description
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.1↗In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.2↗,3↗ FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.2↗,3↗,4↗
Synonyms FTY720P
Formal Name 2-​amino-​2[2-​(4-​octylphenyl)ethyl]-​1,​3-​propanediol,​ mono dihydrogen phosphate ester
CAS Number 402615-91-2
Molecular Formula C19H34NO5P
Formula Weight 387.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCC1=CC=C(CCC([NH3+]​)​(COP([O-]​)​(O)​=O)​CO)​C=C1 
InCHI Code 1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)​13-14-19(20,15-21)​16-25-26(22,23)​24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)​
InCHI Key LRFKWQGGENFBFO-UHFFFAOYSA-N

-20°C