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539185-10MG   Proteasome Inhibitor XX, GL5   品牌 Merck

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Proteasome Inhibitor XX, GL5

货号： 539185-10MG      产品名称： Proteasome Inhibitor XX, GL5   品牌： Merck 规格： *** 3周到货 生化实验

Proteasome Inhibitor XX, GL5
5-(5-Methyl-2-(methylthio)thiophen-3-yl)-1,3,4-oxathiazol-2-one
A cell-permeable thienyl-oxathiazolone compound that effectively kills non-replicating Mycobacterium tuberculosis (~320- or 12,600-fold drop in BCG titre over 4 days by 50 µM GL5 with or without 50 µM DETA-NO, respectively) by selectively inhibiting its proteasome activity (by ~90% over 4 hours with 50 µM GL5) in a substrate-competitive and irreversible manner, while exhibiting little activity against trypsin, cathepsin B, MMP-2, or human 20S proteasome β1/2/5. GL5 displays no antibacterial activity against M. avium-intracellulare, Staphylococcus aureus, Salmonella enterica var. Typhimurium, or Pseudomonas aeruginosa. Although GL5 is known to reversibly inhibit α-chymotrypsin (Ki = 0.064 µM), it exerts no apparent toxicity to human or monkey cells. GL5 is reasonably stable in RPMI medium (t1/2 = 110 mins at 37°C) albeit its moderate chemical reactivity toward glutathione (12.7% over 30 min at pH 7.0, RT; 10 µM GL5 and 25 µM GSH).
产品信息
Form  Brown solid
Molar mass  245.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C8H7NO2S3
CAS number  146304-91-8
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling

-20°C

565789-1MG   γ-Secretase Inhibitor XX   品牌 Merck

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γ-Secretase Inhibitor XX

货号： 565789-1MG      产品名称： γ-Secretase Inhibitor XX   品牌： Merck 规格： *** 3周到货 生化实验

γ-Secretase Inhibitor XX
(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
A cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p).
产品信息
Form  White solid
Primary Target  γ-secretase
Secondary target  Notch processing (IC50 = 1.7 nM in SupT1 cells)
Molar mass  463.4
Protect from Light  是的
Packaged under inert gas  是的
Cell permeable  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C26H23F2N3O3
CAS number  209984-56-5
商店和运输信息
Storage  -20°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling

-20°C

4336799   37XX BDT V1.1 SEQ STD KIT   品牌 Invitrogen

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37XX BDT V1.1 SEQ STD KIT

货号： 4336799      产品名称： 37XX BDT V1.1 SEQ STD KIT   品牌： Invitrogen 规格： EACH 三周到货 生化试验

3730/3730xl DNA Analyzer Sequencing Standards, BigDye® Terminator v1.1
This kit contains four tubes of hsp69 standard sequence used for instrument and spectral calibrations. This material is used with the 3730, and 3730xl DNA Analyzers.
For Research Use Only. Not for use in diagnostics procedures.
Platform: 3730xl DNA Analyzer,
3730 DNA Analyzer 
Label or Dye: TAMRA™,
ROX™,
Rhodamine 6G,
Rhodamine 110 
Product Size: 1 kit 
Shipping Condition: Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
This kit contains 4 tubes of hsp69 standard sequence used for instrument and spectral calibrations. This material is used with the 3730, and 3730xl DNA Analyzers. Store kit at -15 to -25°C.

4336943   37XX BDT V3.1 SEQ STD,KIT   品牌 Invitrogen

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37XX BDT V3.1 SEQ STD,KIT

货号： 4336943      产品名称： 37XX BDT V3.1 SEQ STD,KIT   品牌： Invitrogen 规格： EACH 三周到货 生化试验

3730/3730xl DNA Analyzer Sequencing Standards, BigDye® Terminator v3.1
This kit contains four tubes of hsp69 standard sequence used for instrument and spectral calibrations. This material is used with the 3730, and 3730xl DNA Analyzers.
For Research Use Only. Not for use in diagnostics procedures.
Platform: 3730xl DNA Analyzer,
3730 DNA Analyzer 
Product Size: 1 kit 
Shipping Condition: Dry Ice 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
This kit contains 4 tubes of hsp69 standard sequence used for instrument and spectral calibrations. This material is used with the 3730, and 3730xl DNA Analyzers. Store kit at -15 to -25°C.

XX100-100   Non-Categorized   品牌 LKT

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Non-Categorized

货号： XX100-100      产品名称： Non-Categorized   品牌： LKT 规格： 100 三周到货 生化试验

Non-Categorized Drug Discovery Kit
Description
The compounds that are included are 11,12-Dimethoxydihydrokawain, 11-Methoxyyangonin, Dihydromyristicin, Flavokawain A, Flavokawain B, 1-ITC-6-(Methylsulfenyl)-hexane, 1-ITC-6-(Methylsulfinyl)-hexane, Acarbose. The standard volume is 100 ul per well.
See more information about our Drug Discovery Kits    
Specifications 
Product ID  XX100
Product Name  Non-Categorized Drug Discovery Kit
Store Temp -80oC
Ship Temp Dry Ice
 

-80oC

XX101-100   Non-Categorized   品牌 LKT

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Non-Categorized

货号： XX101-100      产品名称： Non-Categorized   品牌： LKT 规格： 100 三周到货 生化试验

Non-Categorized Drug Discovery Kit
Description
The compounds that are included are Levodopa, Methyldopa, 4′-Demethylepipodophyllotoxin, Aminophylline anhydrous, Doxofylline, Raloxifene HCl, Sulfadimethoxine, Tazobactum. The standard volume is 100 ul per well.
See more information about our Drug Discovery Kits    
Specifications 
Product ID  XX101
Product Name  Non-Categorized Drug Discovery Kit
Store Temp -80oC
Ship Temp Dry Ice
 

-80oC

XX102-100   Non-Categorized   品牌 LKT

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Non-Categorized

货号： XX102-100      产品名称： Non-Categorized   品牌： LKT 规格： 100 三周到货 生化试验

Non-Categorized Drug Discovery Kit
Description
The compounds that are included are Carbimazole, Fenbendazole, Letrozole, Pantoprazole sodium, Ricobendazole, Tenatoprazole, Tinidazole, Venlafaxine HCl. The standard volume is 100 ul per well.
See more information about our Drug Discovery Kits     
Specifications 
Product ID  XX102
Product Name  Non-Categorized Drug Discovery Kit
Store Temp -80oC
Ship Temp Dry Ice
 

-80oC