标签： surfactant

A-SURFACTANT PROTEIN B 50UL

货号： 07-614      产品名称： A-SURFACTANT PROTEIN B 50UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Surfactant Protein B Antibody
Species Reactivity Key Applications Host Format Antibody Type
H, M  IHC, WB Rabbit Serum Polyclonal Antibody
Description:
Anti-Surfactant Protein B Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Surfactant Protein B
Molecular Weight:
8kDa
Immunogen:
Purified human surfactant protein B
Isotype:
IgG
Species Reactivity:
Human
Mouse
Quality Assurance:
routinely evaluated by immunoblot on human bronchiolar lavage fluid.
Purification Method:
Serum
Presentation:
rabbit antiserum containing 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
P07988
Gene Symbol:
SFTPB
SP-B
SFTP3
Phe
PSP-B
SFTB3
SMDP1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Immunohistochemistry
Western Blotting
Entrez Gene Summary:
The SFTPB gene encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Surfactant is composed of phospholipids and other surfactant-associated proteins (Clark et al., 1995 [PubMed 7644495]). See also SFTPA1 (MIM 178630), SFTPC (MIM 178620), and SFTPD (MIM 178635).[supplied by OMIM]
UniProt Summary:
FUNCTION: SwissProt: P07988 # Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
SIZE: 381 amino acids; 42117 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Secreted, extracellular space.
DISEASE: SwissProt: P07988 # Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:265120]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. Inborn errors of pulmonary surfactant metabolism are genetically heterogeneous disorders resulting in severe respiratory insufficiency or failure in full-term neonates or infants. These disorders are associated with various pathologic entities, including pulmonary alveolar proteinosis (PAP), desquamative interstitial pneumonitis (DIP), or cellular non- specific interstitial pneumonitis (NSIP).
SIMILARITY: SwissProt: P07988 ## Contains 1 saposin A-type domain. & Contains 3 saposin B-type domains.
MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).
Brand Family:
Upstate
Product Name:
Anti-Surfactant Protein B Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
Anti-Surfactant Protein B Antibody is an a -20℃