IGFBP-3, RBX-250UG
货号： 09-180 产品名称： IGFBP-3, RBX-250UG 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-IGFBP-3 Antibody
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REFERENCES
Insulin-like growth factor binding protein 3 has opposing actions on malignant and nonmalignant breast epithelial cells that are each reversible and dependent upon cholesterol-stabilized integrin receptor complexes
Burrows, C, et al (2006) Endocrinology, 147:3484-500 (2006)
A prospective study of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations with birth weight, gender, growth velocity, and breastfeeding
Chellakooty, M, et al (2006) J Clin Endocrinol Metab, 91:820-6 (2006)
Differential insulin-like growth factor (IGF)-independent interactions of IGF binding protein-3 and IGF binding protein-5 on apoptosis in human breast cancer cells. Involvement of the mitochondria
Perks, C M, et al (2000) J Cell Biochem, 80:248-58 (2000)
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Purified Polyclonal Antibody
Description:
Anti-IGFBP-3 Antibody
Promotional Text:
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes IGFBP-3
Molecular Weight:
31.7 kDa
Immunogen:
KLH conjugated synthetic peptide corresponding to the C-terminus of rat IGFBP-3.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Protein G purfied
Storage Conditions:
2 years at 4°C from date of shipment
UniProt Number:
P17936
Entrez Gene Number:
NM_000598.4
NM_001013398.1
Gene Symbol:
IGFBP3
IBP3
IGFBP-3
BP-53
Alternate Names:
Insulin-like Growth Factor Binding Protein 3, IGF-binding protein 3; acid stable subunit of the 140 K IGF complex
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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UniProt Summary:
FUNCTION: SwissProt: P17936 # IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
SIZE: 291 amino acids; 31674 Da
SUBUNIT: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by most tissues.
DEVELOPMENTAL STAGE: IGFBP3 levels are higher during extrauterine life and peak during puberty.
DOMAIN: SwissProt: P17936 The thyroglobulin type-1 domain mediates interaction with HN.
SIMILARITY: Contains 1 IGFBP N-terminal doma 4℃
09-209 EPHEXIN, RBX-100UG 品牌 Millipore
EPHEXIN, RBX-100UG
货号： 09-209 产品名称： EPHEXIN, RBX-100UG 品牌： Millipore 规格： EA
09-217 RAPTOR, RBX 品牌 Millipore
RAPTOR, RBX
货号： 09-217 产品名称： RAPTOR, RBX 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-Raptor Antibody
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REFERENCES
Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters.
Bruno D Fonseca,Tommy Alain,Leona K Finestone,Brandon P H Huang,Mark Rolfe,Tian Jiang,Zhong Yao,Greco Hernandez,Christopher F Bennett,Christopher G Proud (2011) The Journal of biological chemistry.286
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Peterson, Timothy R, et al. (2009) Cell, 137: 873-86 (2009)
Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.
Sarbassov, Dos D and Sabatini, David M (2005) J. Biol. Chem., 280: 39505-9 (2005)
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Hara, Kenta, et al. (2002) Cell, 110: 177-89 (2002)
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Species Reactivity Key Applications Host Format Antibody Type
H IP, WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Raptor Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Molecular Weight:
150 kDa
Immunogen:
KLH conjugated peptide encompassing the N-terminal region of human Raptor.
Isotype:
IgG
Species Reactivity:
Human
Species Reactivity Note:
Other species have not been tested.
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Immunoaffinity purified
Presentation:
Affinity purified rabbit polyclonal IgG in 0.02M PBS, 0.25M sodium chloride containing 0.1% sodium azide and 50% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q8N122
Entrez Gene Number:
NM_020761.2
Gene Symbol:
KIAA1303
Raptor
Alternate Names:
p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats; regulatory associated protein of mTOR
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q8N122 # Participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). Plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. Has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
SIZE: 1335 amino acids; 149038 Da
SUBUNIT: Binds directly 4EBP1 and RPS6KB1 independently of its association with FRAP1. Binds preferentially to poorly or non- phosphorylated form of EIF4EBP1, and this binding is critical to the ability of FRAP1 to catalyze phosphorylation. Complex with FRAP1 physically interacts under both leucine-rich and -poor conditions and therefore in at least two nutrient-determined states w -20℃
09-456 msAIRE,RBX,100UG 品牌 Millipore
msAIRE,RBX,100UG
货号： 09-456 产品名称： msAIRE,RBX,100UG 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-AIRE
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REFERENCES
Gene dosage–limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.
Liston, Adrian, et al. (2004) J. Exp. Med., 200: 1015-26 (2004)
Projection of an immunological self shadow within the thymus by the aire protein.
Anderson, Mark S, et al. (2002) Science, 298: 1395-401 (2002)
Modifier loci condition autoimmunity provoked by Aire deficiency
Jiang, Wenyu, et al (2005) J Exp Med, 202:805-15 (2005)
Aire-ing self antigen variability and tolerance.
Holmdahl, Rikard (2007) Eur. J. Immunol., 37: 598-601 (2007)
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Species Reactivity Key Applications Host Format Antibody Type
M WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-AIRE Antibody
Promotional Text:
Special Shipping Offer on Antibodies
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes murine AIRE, Mr 58 kDa (calculated). Appears at ~65 kDa in Western blots.
Molecular Weight:
65 kDa
Epitope:
a.a. 162-181
Immunogen:
KLH-conjugated synthetic peptide corresponding to amino acids 162-181 of mouse AIRE
Isotype:
IgG
Background Information:
AIRE (Autoimmune Regulator) is a human gene that is expressed primarily in the thymus. It causes transcription of a wide selection of organ-specific genes, reducing the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells via negative selection. Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendo-crinopathy-candidiasis-ectodermal dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis. Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease. Aire is atranscriptional regulator protein that binds to DNA as dimer and tetramer, but not as a monomer. It forms nuclear bodies and interacts with the transcriptional coactivator CBP (CREBBP). At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD).
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Species Reactivity:
Mouse
Species Reactivity Note:
Mouse. Likely to cross-react with rat, based on sequence homology. Cross-reactivity with other species has not been tested
Application Notes:
Suggested dilutions:
Western blot: 1:1000
Control:
Murine thymus tissue lysate
Quality Assurance:
Routinely evaluated by Western Blot analysis.
Western Blot:
A 1:1000 dilution of this lot detected AIRE in murine thymus lysate
Purification Method:
Immunoaffinity purified
Presentation:
100 μg of immunoaffinity purified rabbit polyclonal IgG in 173 μl of 0.02M PBS, 0.25M NaCl containing 0.1% sodium azide
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
O43918
Entrez Gene Number:
NM_ -20℃
09-726 PAI-1, RBX-100UG 品牌 Millipore
PAI-1, RBX-100UG
货号： 09-726 产品名称： PAI-1, RBX-100UG 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-PAI-1 Antibody
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REFERENCES
The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin
Roncal, C, et al (2006) J Thromb Haemost, 4:1798-803 (2006)
Genetic polymorphisms of TGF-beta, PAI-1, and COL1A-1, and determination of bone mineral density in Caucasian females
Hubacek, Jaroslav A, et al (2006) Endocrine regulations, 40:77-81 (2006)
PAI-1 expression levels in esophageal and colorectal cancers are closely correlated to those in corresponding normal tissues
Sakakibara, T, et alAnticancer Res, 26:4343-7 ()
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Purified Polyclonal Antibody
Description:
Anti-PAI-1 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
PAI-1
Molecular Weight:
~50 kDa
Immunogen:
Recombinant human PAI-1
Isotype:
IgG
Species Reactivity:
Human
Application Notes:
Western Blot: 1:1,000 dilution using jurkat cell lysates.
Optimal working dilutions must be determined by the end user.
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Protein A purfied
Presentation:
100 μg of Protein A purified rabbit polyclonal IgG in 1X PBS with 0.1% sodium azide.
Storage Conditions:
2 years at -20°C from date of shipment.
UniProt Number:
P05121
Entrez Gene Number:
NM_000602.1
Gene Symbol:
SERPINE1
PAI
PLANH1
PAI-1
PAI1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P05121 # This inhibitor acts as ‘bait’ for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis.
SIZE: 402 amino acids; 45060 Da
SUBUNIT: Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
PTM: Inactivated by proteolytic attack of the urokinase-type (u- PA) and the tissue-type (TPA), cleaving the 369-Arg- -Met-370 bond.
DISEASE: SwissProt: P05121 # Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) [MIM:173360]. This deficiency is characterized by abnormal bleeding due to SERPINE1 defect in the plasma. & High concentrations of SERPINE1 have been associated with thrombophilia [MIM:188050]; an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis.
SIMILARITY: SwissProt: P05121 ## Belongs to the serpin family.
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Brand Family:
Upstate
Product Name:
Anti-PAI-1 Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µg
Format:
Purified
Host:
Rabbit
Applications:
This Anti-PAI-1 Antibody is validated for use in WB for the detection of PAI-1.
-20℃
38430-K MYELOPEROXIDASE, RBX-2ML 品牌 Millipore
MYELOPEROXIDASE, RBX-2ML
货号： 38430-K 产品名称： MYELOPEROXIDASE, RBX-2ML 品牌： Millipore 规格： ML
AB3848-K PHOSPHO-SMAD1, RBX – ML 品牌 Millipore
PHOSPHO-SMAD1, RBX – ML
货号： AB3848-K 产品名称： PHOSPHO-SMAD1, RBX – ML 品牌： Millipore 规格： *** 三周到货 生化实验
Anti-phospho-Smad1/Smad5/Smad8 Antibody, phospho-specific (Ser463/465)
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REFERENCES
Wang Q, Zhao G, Xing S, Zhang L, Yang X (2011) Molecular vision.17:647-57.
Wang Q, Zhao G, Xing S, Zhang L, Yang X (2011) Molecular vision.17:647-57.
Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.
R Barros,B Pereira,I Duluc,M Azevedo,N Mendes,V Camilo,R J Jacobs,P Paulo,F Santos-Silva,I van Seuningen,G R van den Brink,L David,J-N Freund,R Almeida (2008) The Journal of pathology.215
Border formation in a Bmp gradient reduced to single dissociated cells.
Jia Sheng Hu,Linda T Doan,D Spencer Currle,Michelle Paff,Justin Y Rheem,Rachel Schreyer,Benoit Robert,Edwin S Monuki (2008) Proceedings of the National Academy of Sciences of the United States of America.105
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Mi, Xn FC, ICC, IH(P), WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-Smad1/Smad5/Smad8 Antibody, phospho-specific (Ser463/465)
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Recognizes Smad1 only when dually phosphorylated at Ser463 and Ser465, as well as phosphorylated Smad5 and Smad8 at the equivalent sites. This antibody does not crossreact with other Smad-related proteins.
Molecular Weight:
53 kDa
Epitope:
phospho-specific (Ser463/465)
Immunogen:
KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser463/465 of human Smad5.
Modifications:
Phosphorylation
Background Information:
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).
Species Reactivity:
Human
Mouse
Rat
Mink
Xenopus
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Species Reactivity Note:
Human and mouse Expected to cross-react with rat, mink, and Xenopus. Reactivity with other species has not been determined.
Application Notes:
Immunohistochemistry (Paraffin): 1:100 dilutoin of a previous lot was used; a high heat antigen retrieval technique is suggested using a citrate/TBST buffer.
Immunocytochemistry (IF):
1:100 dilution of a previous lot was used.
Flow Cytometry:
1:50 dilution of a previous lot was used
Western blotting:
1:1,000. For best results, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight.
Optimal working dilutions must be determined by the end user.
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Control:
BMP-4-treated HeLa or NIH/3T3 cells Embryo.
Quality Assurance:
Routinely evaluated by Western Blot on untreated and BMP2 treated HEK293 lysates.
Western Blot Analysis: 1:500 dilution of this lot detected pSmad1/5/8 on 10 μg of BMP2 treated HEK293 lysates.
Purification Method:
Immunoaffinity purified
Presentation:
Affinity purified rabbit polyclonal in buffer containing 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, with 50% glycerol.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt. Do not aliquot antibody.
Handling Recommendations:
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
View All »
UniProt Number:
-20℃
CUS7396 NMDAR1, RBx SUP – ML 品牌 Millipore
NMDAR1, RBx SUP – ML
货号： CUS7396 产品名称： NMDAR1, RBx SUP – ML 品牌： Millipore 规格： ***
AB10050 p-ITCH (pT222), Rbx-100ug 品牌 Millipore
p-ITCH (pT222), Rbx-100ug
货号： AB10050 产品名称： p-ITCH (pT222), Rbx-100ug 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-phospho-ITCH (pT222) Antibody
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REFERENCES
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.
Gao, Min, et al. (2004) Science, 306: 271-5 (2004)
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M. (2006) Cell, 123(3):601-13 (2006)
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.
Gallagher E, Gao M, Liu YC, Karin M. (2006) Proc Natl Acad Sci U S A. , 6:1717-1722 (2006)
Species Reactivity Key Applications Host Format Antibody Type
H DB, WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-phospho-ITCH (pT222) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Human ITCH phosphorylated on threonine 222 (T222).
Immunogen:
Synthetic peptide corresponding to a portion of human ITCH encompassing the phosphorylated Threonine at position 222 (PPPpTPRRP).
Modifications:
Phosphorylation
Background Information:
ITCH is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. ITCH regulates the transcriptional activity of several transcription factors including the hematopoietic transcription factor NF-E2, and may play an important role in the regulation of immune response. ITCH down-regulates Epstein-Barr virus LMP2A activity in B cell signaling, and also interacts with NOTCH1, OCLN, JUN, and JUNB. ITCH has a wide tissue distribution and is localized within the nucleus and cytoplasm. Two ITCH splice variants have been described; an approximately 103 kDa form as well as a truncated form (~98 kDa) lacking 42 amino acids in the N-terminal half of the protein. ITCH contains a MAP Kinase binding site and its activity is modulated by phosphorylation at multiple threonine residues by JNK1.
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Species Reactivity:
Human
Application Notes:
Western Blot: Recommended Dilution 1 – 5 μg/mL
Dot Blot
Presentation:
Affinity purified immunoglobulin. Liquid in Tris-citrate/phosphate buffer, pH 7-8, containing 0.1% sodium azide.
Storage Conditions:
Maintain at 2-8°C for up to 12 months from date of receipt
UniProt Number:
Q96J02
Entrez Gene Number:
NM_031483.3
Gene Symbol:
ITCH
NAPP1
dJ468O1.1
Itch
AIF4
AIP4
View All »
Alternate Names:
Itchy homolog E3 ubiquitin protein ligase; AIP4; NAPP1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Dot Blot
Western Blotting
Entrez Gene Summary:
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains a 2-8℃
AB10076 HCYP450 3A5, RBX-100UL 品牌 Millipore
HCYP450 3A5, RBX-100UL
货号： AB10076 产品名称： HCYP450 3A5, RBX-100UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-3A5 Antibody
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Serum Polyclonal Antibody
Description:
Anti-3A5 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
57kDa
Epitope:
AA 42 to 83
Immunogen:
Recombinant human 3A5
Background Information:
CYP3A (cytochrome P450, family 3, subfamily A), is a member of the cytochrome P450 superfamily of monooxygenase enzymes which catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids.
Species Reactivity:
Human
Application Notes:
Western Blot: 1:5000
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
Raw rabbit serum with 0.05% sodium azide.
Storage Conditions:
Maintain at -20°C for up to 12 months from date of receipt.
UniProt Number:
P20815
Entrez Gene Number:
NP_000768
Gene Symbol:
CYPIIIA5
P450-PCN3
EC 1.14.14.1
HLp2
Alternate Names:
Cytochrome P450 3A5
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene.
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UniProt Summary:
FUNCTION: SwissProt: P20815 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
SIZE: 502 amino acids; 57109 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt:P20815 # Belongs to the cytochrome P450 family.
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Brand Family:
Chemicon
Product Name:
Anti-3A5 Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
Anti-3A5 Antibody is an antibody against 3A5 for use in WB.
-20℃
AB10079 CYP2B1 RAT, RBX-100UL 品牌 Millipore
CYP2B1 RAT, RBX-100UL
货号： AB10079 产品名称： CYP2B1 RAT, RBX-100UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-Cytochrome P450 CYP450 2B1 Antibody
Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rabbit Serum Polyclonal Antibody
Description:
Anti-Cytochrome P450 CYP450 2B1 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
56kDa
Immunogen:
Recombinant CYP450 2B1
Background Information:
P450s are the major enzymes involved in drug metabolism.Cytochrome P450 is the most important element of oxidative metabolism. The CYP450 2B1 is a mono-oxygenase which catalyzes many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids.
Species Reactivity:
Human
Mouse
Rat
Application Notes:
Suggested dilutions:
Western Blot: 1:2000
Quality Assurance:
Routinely evaluated by Western Blot
Presentation:
Raw rabbit serum with 0.05% sodium azide.
Storage Conditions:
Maintain at -20°C for up to 12 months from date of receipt.
UniProt Number:
P00176
Alternate Names:
Cytochrome P450 CYP450 2B1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Brand Family:
Chemicon
Product Name:
Anti-Cytochrome P450 CYP450 2B1 Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
Anti-Cytochrome P450 CYP450 2B1 Antibody detects level of Cytochrome P450 CYP450 2B1 & has been published & validated for use in WB.
-20℃
AB10080 CYP450-2E1, RBX-50UL 品牌 Millipore
CYP450-2E1, RBX-50UL
货号： AB10080 产品名称： CYP450-2E1, RBX-50UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-CYP450 Antibody, clone 2E1
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REFERENCES
Cytochrome P450 and Parkinson’s disease: protective role of neuronal CYP 2E1 from MPTP toxicity
Viaggi, C, et al (2006) J Neural Transm Suppl, :173-6 (2006)
Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite
Cannady, Ellen A, et al (2003) Toxicol Sci, 73:423-30 (2003)
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Serum Polyclonal Antibody
Description:
Anti-CYP450 Antibody, clone 2E1
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
57 kDa
Immunogen:
Recombinant CYP450 2E1
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
Raw Rabbit Serum with 0.1% Sodium Azide
Storage Conditions:
1 year at 2-8°C from date of shipment
UniProt Number:
P05181
Entrez Gene Number:
NM_000773.3
Gene Symbol:
CYP2E1
OTTHUMP00000046571
CYPIIE1
CYP2E
P450C2E
P450-J
CPE1
View All »
Alternate Names:
cytochrome P450
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
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UniProt Summary:
FUNCTION: SwissProt: P05181 # Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
SIZE: 493 amino acids; 56849 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SIMILARITY: SwissProt: P05181 ## Belongs to the cytochrome P450 family.
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Brand Family:
Chemicon
Product Name:
Anti-CYP450 Antibody, clone 2E1
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
Anti-CYP450 Antibody, clone 2E1 is an antibody against CYP450 for use in WB.
2-8℃
AB10081 CXR-18 (G), RBX-50UL 品牌 Millipore
CXR-18 (G), RBX-50UL
货号： AB10081 产品名称： CXR-18 (G), RBX-50UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-CYP2D6 Antibody
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REFERENCES
Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype.
García-Quetglas, Emilio, et al. (2007) Pharmacol. Res., 55: 122-30 (2007)
Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal breast cancer patients
Wegman, Pia, et al (2007) Breast Cancer Res. , 9:R7 [Epub ahead of print] (2007)
Determination of CYP2D6, CYP2C9 and CYP2C19 genotypes with Tag-It mutation detection assays
Melis, Roberta, et al (2006) Expert Rev Mol Diagn, 6:811-20 (2006)
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Serum Polyclonal Antibody
Description:
Anti-CYP2D6 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
58kDa
Immunogen:
Recombinant human CYP2D6
Isotype:
IgG2b
Background Information:
Cytochrome P450 2D6 (CYP2D6), a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. Whilst CYP2D6 is involved in the oxidation of a wide range of substrates of all the CYPs, there is considerable variability in its expression in the liver.
Species Reactivity:
Human
Application Notes:
Suggested dilutions:
Western Blot: 1:5000
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
Raw rabbit serum with 0.1% sodium azide.
Storage Conditions:
Maintain at 2-8°C for up to 12 months from date of receipt.
UniProt Number:
P10635
Entrez Gene Number:
NM_000106.4
NM_001025161.1
Gene Symbol:
CYP2D6
P450C2D
MGC120389
CPD6
P450-DB1
CYPIID6
MGC120390
CYP2D
CYP2DL1
CYP2D@
View All »
Alternate Names:
Cytochrome P450 2D6
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme’s substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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UniProt Summary:
FUNCTION: SwissProt: P10635 # Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
SIZE: 497 amino acids; 55769 Da
SUBCELLULAR LOCATION: Endoplasmic ret 2-8℃
AB10088 CXR-31 (G), RBX-50UL 品牌 Millipore
CXR-31 (G), RBX-50UL
货号： AB10088 产品名称： CXR-31 (G), RBX-50UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-CYP450 1A1 Antibody
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REFERENCES
Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers
Smith, Cornelia M, et alJ Biochem Mol Toxicol, 19:96-108 ()
Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo
Thapliyal, R and Maru, G B (2001) Food Chem Toxicol, 39:541-7 (2001)
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Serum Polyclonal Antibody
Description:
Anti-CYP450 1A1 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
58 kDa
Immunogen:
Recombinant CYP450 1A1
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Presentation:
Raw Rabbit Serum with 0.1% Sodium Azide
Storage Conditions:
1 year at 2-8°C from date of shipment
UniProt Number:
P04798
Entrez Gene Number:
NM_000499.2
Gene Symbol:
CYP1A1
CP11
P1-450
CYPIA1
P450-C
CYP1
P450DX
P450-P1
AHRR
AHH
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Alternate Names:
Cytochrome P450
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme’s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
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UniProt Summary:
FUNCTION: SwissProt: P04798 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
SIZE: 512 amino acids; 58165 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
SIMILARITY: SwissProt: P04798 ## Belongs to the cytochrome P450 family.
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Brand Family:
Chemicon
Product Name:
Anti-CYP450 1A1 Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
This Anti-CYP450 1A1 Antibody is validated for use in WB for the detection of CYP450 1A1.
2-8℃
AB10089 CXR-35 (G), RBX-50UL 品牌 Millipore
CXR-35 (G), RBX-50UL
货号： AB10089 产品名称： CXR-35 (G), RBX-50UL 品牌： Millipore 规格： EA
AB10093 Anti-GST theta 1, RBX-50ul 品牌 Millipore
Anti-GST theta 1, RBX-50ul
货号： AB10093 产品名称： Anti-GST theta 1, RBX-50ul 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-GST θ 1 Antibody
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REFERENCES
The evolution of catalytic efficiency and substrate promiscuity in human theta class 1-1 glutathione transferase
Griswold, Karl E, et al (2006) J Mol Biol, 364:400-10 (2006)
Differences in the subunit interface residues of alternatively spliced glutathione transferases affects catalytic and structural functions
Piromjitpong, Juthamart, et al (2007) Biochem J, 401:635-44 (2007)
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Serum Polyclonal Antibody
Description:
Anti-GST θ 1 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
26kDa
Immunogen:
Recombinant GST Theta 1
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Presentation:
Raw Rabbit Serum with 0.1% Sodium Azide
Storage Conditions:
1 year at 2-8°C from date of shipment
UniProt Number:
P30711
Entrez Gene Number:
NM_000853.1
Gene Symbol:
GSTT1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.
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UniProt Summary:
FUNCTION: SwissProt: P30711 # Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.
SIZE: 240 amino acids; 27335 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
SIMILARITY: SwissProt: P30711 ## Belongs to the GST superfamily. Theta family.
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Brand Family:
Chemicon
Product Name:
Anti-GST θ 1 Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
Anti-GST θ 1 Antibody is an antibody against GST θ 1 for use in WB.
2-8℃
AB10094 PPARd HUMAN, RBX-100UL 品牌 Millipore
PPARd HUMAN, RBX-100UL
货号： AB10094 产品名称： PPARd HUMAN, RBX-100UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-hPPAR-δ Antibody
Species Reactivity Key Applications Host Format Antibody Type
H, R, M WB Rabbit Serum Polyclonal Antibody
Description:
Anti-hPPAR-δ Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
50 kDa
Epitope:
a.a. 1-71
Immunogen:
Recombinant rat
Background Information:
Peroxisome proliferator-activated receptor delta (PPAR-δ or PPAR-β), also known as NR1C2 (nuclear receptor subfamily 1, group C, member 2) is a nuclear receptor encoded by the PPARD genePPARs are nuclear hormone receptors that bind peroxisome proliferators. PPARs mediate a variety of processes, and may be involved in several diseases, including diabetes, obesity, atherosclerosis, and cancer.
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Species Reactivity:
Human
Rat
Mouse
Application Notes:
Suggested dilutions:
Western Blot: 1:5000
Quality Assurance:
Routinely evaluated by Western blot.
Presentation:
Raw rabbit serum with 0.05% sodium azide.
Storage Conditions:
Maintain at -20°C for up to 12 months from date of receipt.
UniProt Number:
P37231
Entrez Gene Number:
NP_005028
Alternate Names:
Cytochrome P450 3A7
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Brand Family:
Chemicon
Product Name:
Anti-hPPAR-δ Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
Detect the hPPAR-δ protein using this Anti-hPPAR-δ validated for use in WB.
-20℃
AB10200 PERILIPIN A, RBX-100UG 品牌 Millipore
PERILIPIN A, RBX-100UG
货号： AB10200 产品名称： PERILIPIN A, RBX-100UG 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-Perilipin A Antibody
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REFERENCES
Coordination of lipid droplet-associated proteins during the transition period of Holstein dairy cows.
Koltes DA, Spurlock DM (2011) J Dairy Sci.94:1839-48.
Coordination of lipid droplet-associated proteins during the transition period of Holstein dairy cows.
D A Koltes,D M Spurlock (2011) Journal of dairy science.94
Coordination of lipid droplet-associated proteins during the transition period of Holstein dairy cows.
Koltes DA, Spurlock DM (2011) J Dairy Sci.94:1839-48.
mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes.
Ghada A Soliman,Hugo A Acosta-Jaquez,Diane C Fingar (2010) Lipids.45
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Species Reactivity Key Applications Host Format Antibody Type
B, M WB Rabbit Purified Polyclonal Antibody
Description:
Anti-Perilipin A Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
64kDa
Immunogen:
Bovine Perilipin A
Background Information:
Perilipin A is the predominant isoform of perilipins a family of proteins which are the most abundant proteins at the surfaces of lipid droplets in adipocytes and are also found in steroidogenic cells.
Species Reactivity:
Bovine
Mouse
Application Notes:
Suggested dilutions:
Western Blot: 0.1-0.2 μg/mL
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
Purified immunoglobulin presented as a liquid in 0.1 M Na-Phosphate buffer, pH 7.0 containing protease free bovine serum albumin.
Storage Conditions:
Maintain frozen at -20C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze-thaw cycles.
UniProt Number:
O60240
Entrez Gene Number:
NM_002666.3
Gene Symbol:
PLIN
PERI
Perilipin
perilipin
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis.
UniProt Summary:
FUNCTION: SwissProt: O60240 # Modulator of adipocyte lipid metabolism, it coats lipid storage droplets to protect them to be broken down by hormone- sensitive lipase (HSL). Its absence may result in leanness.
SIZE: 522 amino acids; 55950 Da
SUBUNIT: Interacts with ABHD5 (By similarity).
SUBCELLULAR LOCATION: Lipid droplet (By similarity). Note=Lipid droplet surface-associated (By similarity).
TISSUE SPECIFICITY: Adipocytes.
PTM: Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity).
SIMILARITY: SwissProt: O60240 ## Belongs to the perilipin family.
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Brand Family:
Chemicon
Product Name:
Anti-Perilipin A Antibody
Con -20℃
AB10300 h CYP2A6, RBX-50UL 品牌 Millipore
h CYP2A6, RBX-50UL
货号： AB10300 产品名称： h CYP2A6, RBX-50UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-CYP2A6 Antibody
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REFERENCES
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine
Benowitz, Neal L, et al (2006) Clin Pharmacol Ther, 80:457-67 (2006)
Metabolism of (+)-fenchone by CYP2A6 and CYP2B6 in human liver microsomes
Miyazawa, Mitsuo and Gyoubu, Kunihiko (2006) Biol Pharm Bull, 29:2354-8 (2006)
Inhibitory effects of neurotransmitters and steroids on human CYP2A6
(2007) Higasi, Eriko, et al
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Serum Polyclonal Antibody
Description:
Anti-CYP2A6 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
57kDa
Immunogen:
Recombinant human CYP2A6
Isotype:
IgG2b
Background Information:
Cytochrome P450 2A6 (CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system. It is involved in the metabolism of various xenobiotics including nicotine and cotinine.
Species Reactivity:
Human
Application Notes:
Suggested dilutions:
Western Blot: 1:5000
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
Raw rabbit serum with 0.1% sodium azide.
Storage Conditions:
Maintain at 2-8°C for up to 12 months from date of receipt.
UniProt Number:
P11509
Entrez Gene Number:
NM_000762.4
Gene Symbol:
CYP2A6
P450
I.
CPA6
P450C2A
P450PB
CYP2A3
CYP2A
CYPIIA6
View All »
Alternate Names:
Cytochrome P450 2A6
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
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UniProt Summary:
FUNCTION: SwissProt: P11509 # Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase.
SIZE: 494 amino acids; 56517 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Liver.
SIMILARITY: SwissProt: P11509 ## Belongs to the cytochrome P450 family.
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Brand Family:
Chemicon
Product Name:
Anti-CYP2A6 Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µ 2-8℃
AB10301 h POR, RBX-50UL 品牌 Millipore
h POR, RBX-50UL
货号： AB10301 产品名称： h POR, RBX-50UL 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-POR Antibody
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REFERENCES
Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.
Grunau, Alex, et al. (2006) Biochemistry, 45: 1421-34 (2006)
The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450-mediated biotransformation (a corrigendum report on Duarte et al. (2005) Mutagenesis 20, 93-100
Duarte, Maria Paula, et al (2007) Mutagenesis, 22:75-81 (2007)
Human cytochrome P450 reductase can act as a source of endogenous oxidative DNA damage and genetic instability
Heine, Tina, et al (2006) Free Radic Biol Med, 40:801-7 (2006)
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Serum Polyclonal Antibody
Description:
Anti-POR Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Molecular Weight:
77kDa
Immunogen:
Recombinant human hPOR
Isotype:
IgG2b
Background Information:
NADPH-cytochrome P450 oxidoreductase (POR) catalyzes transfer of electrons from NADPH, via two flavin cofactors, FMN and FAD to various cytochrome P450s. Such as cytochrome c. In addition POR facilitates the transfer of electrons to hemeoxygenase the fatty acid elongation system.
Species Reactivity:
Human
Application Notes:
Suggested dilutions:
Western Blot: 1:5000
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
Raw rabbit serum with 0.1% sodium azide.
Storage Conditions:
Maintain at 2-8°C for up to 12 months from date of receipt.
UniProt Number:
P00167
Entrez Gene Number:
NM_001914.2
NM_148923.2
Gene Symbol:
CYB5A
MCB5
CYB5
Alternate Names:
NADPH-cytochrome P450 oxidoreductase
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P00167 # Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
SIZE: 134 amino acids; 15330 Da
SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side. & Isoform 2: Cytoplasm.
DISEASE:SwissProt: P00167 # Defects in CYB5A are the cause of type IV hereditary methemoglobinemia [MIM:250790].
SIMILARITY: SwissProt: P00167 ## Belongs to the cytochrome b5 family. & Contains 1 cytochrome b5 heme-binding domain.
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Brand Family:
Chemicon
Product Name:
Anti-POR Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
This Anti-POR Antibody is validated for use in WB for the detection of POR.
2-8℃