pUNO1-hTLR08b-HA3x
货号： puno1ha-htlr8b 产品名称： pUNO1-hTLR08b-HA3x 品牌： Invivogen 规格： 1 disk 三周到货 生化试验
TLR8-HA
Coding sequence in expression plasmid
Alias: CD288
The gene has been fused at the 3’end to the influenza hemaglutinine (HA) tag. This short sequence (YPYDVPDYA) encodes a peptide which is the epitope of a very efficient and specific monoclonal antibody. The use of HA-tagged genes provides a simple and convenient method to detect the expression of the genes by Western blot.
This gene is available in pUNO1-HA expression plasmid selectable with Blasticidin.
Human TLR8-HA (pUNO1-hTLR08-HA3x)
ORF Size: 3220 bp
Subclone: AgeI – NheI
Mouse TLR8-HA (pUNO1-mTLR08-HA3x)
ORF Size: 3096 bp
Subclone: AgeI – NheI
puno1-htlr8b pUNO1-hTLR08b 品牌 Invivogen
pUNO1-hTLR08b
货号： puno1-htlr8b 产品名称： pUNO1-hTLR08b 品牌： Invivogen 规格： 1 disk 三周到货 生化试验
TLR8 Native Genes
Toll-Like Receptor 8 native genes in expression plasmid
Alias: CD288, TLR08
TLR8 was identified together with TLR7 and TLR9 and is expressed more abundantly in PBL and lung [1].
The natural ligand for TLR8 is still unknown. Human TLR8 and TLR7 were reported to independently confer responsiveness to R848, an imidazoquinoline compound with antiviral activity. Upon R848 stimulation, HEK293 cells transfected with human TLR8 induced NF-κB activation in a dose-dependent manner [2].
In contrast, HEK293 cells expressing murine TLR8 were hyporesponsive to R848 suggesting that TLR8 is nonfunctional in mice.
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR8 Native Genes (pUNO1-bTLR08)
Genbank: EF076722.1
ORF Size: 3102 bp
Subclone: BspHI – NheI
Human TLR8 (pUNO1-hTLR08)
Genbank: NM_138636
ORF Size: 3126 bp
Subclone: AgeI – NheI
Human TLR8 (pUNO3-hTLR08)
Genbank: NM_138636
ORF Size: 3126 bp
Subclone: AgeI – NheI
Mouse TLR8 (pUNO1-mTLR08)
Genbank: NM_133212.2
ORF Size: 3099 bp
Subclone: AgeI – NheI
Pig TLR8 Native Genes (pUNO1-pTLR08)
ORF Size: 3087 bp
Subclone: BspHI – NheI
puno3-htlr8b pUNO3-hTLR08b 品牌 Invivogen
pUNO3-hTLR08b
货号： puno3-htlr8b 产品名称： pUNO3-hTLR08b 品牌： Invivogen 规格： 1 disk 三周到货 生化试验
TLR8 Native Genes
Toll-Like Receptor 8 native genes in expression plasmid
Alias: CD288, TLR08
TLR8 was identified together with TLR7 and TLR9 and is expressed more abundantly in PBL and lung [1].
The natural ligand for TLR8 is still unknown. Human TLR8 and TLR7 were reported to independently confer responsiveness to R848, an imidazoquinoline compound with antiviral activity. Upon R848 stimulation, HEK293 cells transfected with human TLR8 induced NF-κB activation in a dose-dependent manner [2].
In contrast, HEK293 cells expressing murine TLR8 were hyporesponsive to R848 suggesting that TLR8 is nonfunctional in mice.
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR8 Native Genes (pUNO1-bTLR08)
Genbank: EF076722.1
ORF Size: 3102 bp
Subclone: BspHI – NheI
Human TLR8 (pUNO1-hTLR08)
Genbank: NM_138636
ORF Size: 3126 bp
Subclone: AgeI – NheI
Human TLR8 (pUNO3-hTLR08)
Genbank: NM_138636
ORF Size: 3126 bp
Subclone: AgeI – NheI
Mouse TLR8 (pUNO1-mTLR08)
Genbank: NM_133212.2
ORF Size: 3099 bp
Subclone: AgeI – NheI
Pig TLR8 Native Genes (pUNO1-pTLR08)
ORF Size: 3087 bp
Subclone: BspHI – NheI
pzero-htlr8b pZERO-hTLR8 品牌 Invivogen
pZERO-hTLR8
货号： pzero-htlr8b 产品名称： pZERO-hTLR8 品牌： Invivogen 规格： 1 disk 三周到货 生化试验
pZERO-TLR8
TLR8-ΔTIR : Dominant Negative TLR8 gene in expression plasmid
TLR8 was identified together with TLR7 and TLR9 and is expressed more abundantly in PBL and lung [1]. Human TLR8 and TLR7 were reported to independently confer responsiveness to R848, an imidazoquinoline compound with antiviral activity. Upon R848 stimulation, HEK293 cells transfected with human TLR8 induced NF-kB activation in a dose-dependent manner [2]. In contrast, HEK293 cells expressing murine TLR8 were hyporesponsive to R848.
TLR8-ΔTIR is a TIR-less form of the TLR8 generated by deleting the TIR domain (486 bp). This truncated TLR8 gene is still able to recognize its ligands but is unable to induce the signaling cascade.
This gene is available in pZERO expression plasmid selectable with Puromycin or in pZERO-HA expression plasmid selectable with Puromycin or in pZERO expression plasmid selectable with Puromycin or in pZERO-HA expression plasmid selectable with Puromycin.
Contents update notification
All InvivoGen plasmids are now provided as lyophilized DNA.
Human TLR8-ΔTIR (pZERO-hTLR8)
ORF Size: 2640 bp
Subclone: AgeI – NheI
Human TLR8-ΔTIR-HA (pZERO-hTLR8-HA)
ORF Size: 2673 bp
Subclone: AgeI-NheI
Mouse TLR8-ΔTIR (pZERO-mTLR8)
ORF Size: 2610bp
Subclone: AgeI – NheI
Mouse TLR8-ΔTIR-HA (pZERO-mTLR8-HA)
pzero-htlr8b-ha pZERO-hTLR8-HA 品牌 Invivogen
pZERO-hTLR8-HA
货号： pzero-htlr8b-ha 产品名称： pZERO-hTLR8-HA 品牌： Invivogen 规格： 1 disk 三周到货 生化试验
pZERO-TLR8
TLR8-ΔTIR : Dominant Negative TLR8 gene in expression plasmid
TLR8 was identified together with TLR7 and TLR9 and is expressed more abundantly in PBL and lung [1]. Human TLR8 and TLR7 were reported to independently confer responsiveness to R848, an imidazoquinoline compound with antiviral activity. Upon R848 stimulation, HEK293 cells transfected with human TLR8 induced NF-kB activation in a dose-dependent manner [2]. In contrast, HEK293 cells expressing murine TLR8 were hyporesponsive to R848.
TLR8-ΔTIR is a TIR-less form of the TLR8 generated by deleting the TIR domain (486 bp). This truncated TLR8 gene is still able to recognize its ligands but is unable to induce the signaling cascade.
This gene is available in pZERO expression plasmid selectable with Puromycin or in pZERO-HA expression plasmid selectable with Puromycin or in pZERO expression plasmid selectable with Puromycin or in pZERO-HA expression plasmid selectable with Puromycin.
Contents update notification
All InvivoGen plasmids are now provided as lyophilized DNA.
Human TLR8-ΔTIR (pZERO-hTLR8)
ORF Size: 2640 bp
Subclone: AgeI – NheI
Human TLR8-ΔTIR-HA (pZERO-hTLR8-HA)
ORF Size: 2673 bp
Subclone: AgeI-NheI
Mouse TLR8-ΔTIR (pZERO-mTLR8)
ORF Size: 2610bp
Subclone: AgeI – NheI
Mouse TLR8-ΔTIR-HA (pZERO-mTLR8-HA)