pUNO1-hTLR04a

货号： puno1-htlr4a      产品名称： pUNO1-hTLR04a   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

TLR4 Native Genes
Toll-Like Receptor 4 native genes in expression plasmid
Alias: CD284, TLR4
TLR4, the first human TLR identified, is the receptor for Gram-negative lipopolysaccharide (LPS).
The TLR4 gene was shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS) [1]. However, TLR4 alone is not sufficient to confer LPS responsiveness. TLR4 requires MD-2, a secreted molecule, to functionally interact with LPS [2]. Furthermore, a third protein, called CD14, was shown to participate in LPS signaling, leading to NF-κB translocation. This signaling is mediated through the adapter protein MyD88 but also through a MyD88-independent pathway that involves the (TIR) domain-containing adapter protein (TIRAP) [3].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR4 Native Genes (pUNO1-bTLR04)
Genbank: NM_174198.6
ORF Size: 2526 bp
Subclone: AgeI – NheI
Human TLR4 isoform 1 (pUNO1-hTLR04a)
ORF Size: 2520 bp
Subclone: BspHI – NheI
Human TLR4 isoform 1 (pUNO3-hTLR04a)
 ORF Size: 2520 bp
Subclone: BspHI – NheI
Mouse TLR4 (pUNO1-mTLR04)
Genbank: JX878358.1
ORF Size: 2508 bp
Subclone: BspHI – NheI
Pig TLR4 (pUNO1-pTLR04)
ORF Size: 2526 bp
Subclone: AgeI – NheI

pUNO1-hTLR9a

货号： puno1-htlr9a      产品名称： pUNO1-hTLR9a   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

TLR9 Native Genes
Toll-Like Receptor 9 native genes in expression plasmid
Alias: CD289
TLR9 is expressed in the endoplasmic reticulum of resting cells in contrast to most TLRs that are located on the plasma membrane [1].
TLR9 recognizes specific unmethylated CpG-ODN sequences, that distinguish bacterial DNA from mammalian DNA. TLR9 engages an intracellular signaling pathway that involves MyD88 leading to NF-κB translocation [2].
TLR9 recognizes different CpG motifs; the optimal sequences being GTCGTT and GACGTT for human TLR9 and murine TLR9 respectively [3]. TLR9 binds directly to CpG DNA and recognizes specifically CpG DNA that is unmethylated and single stranded [4].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR9 (pUNO1-bTLR09)
Genbank: EF076731
ORF Size: 3090 bp
Subclone: AgeI – NheI
Human TLR9 isoform 1 (pUNO1-hTLR09a)
ORF Size: 3099 bp
Subclone: MluI – NheI
Human TLR9 isoform 1 (pUNO3-hTLR09a)
ORF Size: 3099 bp
Mouse TLR9 (pUNO1-mTLR09)
ORF Size: 3099 bp
Subclone: AgeI – NheI
Pig TLR9 (pUNO1-pTLR09)
Genbank: AY859728.1
ORF Size: 3093 bp
Subclone: AgeI – NheI

pUNO3-hTLR4a

货号： puno3-htlr4a      产品名称： pUNO3-hTLR4a   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

TLR4 Native Genes
Toll-Like Receptor 4 native genes in expression plasmid
Alias: CD284, TLR4
TLR4, the first human TLR identified, is the receptor for Gram-negative lipopolysaccharide (LPS).
The TLR4 gene was shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS) [1]. However, TLR4 alone is not sufficient to confer LPS responsiveness. TLR4 requires MD-2, a secreted molecule, to functionally interact with LPS [2]. Furthermore, a third protein, called CD14, was shown to participate in LPS signaling, leading to NF-κB translocation. This signaling is mediated through the adapter protein MyD88 but also through a MyD88-independent pathway that involves the (TIR) domain-containing adapter protein (TIRAP) [3].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR4 Native Genes (pUNO1-bTLR04)
Genbank: NM_174198.6
ORF Size: 2526 bp
Subclone: AgeI – NheI
Human TLR4 isoform 1 (pUNO1-hTLR04a)
ORF Size: 2520 bp
Subclone: BspHI – NheI
Human TLR4 isoform 1 (pUNO3-hTLR04a)
ORF Size: 2520 bp
Subclone: BspHI – Nhe
Mouse TLR4 (pUNO1-mTLR04)
Genbank: JX878358.1
ORF Size: 2508 bp
Subclone: BspHI – NheI
Pig TLR4 (pUNO1-pTLR04)
ORF Size: 2526 bp
Subclone: AgeI – NheI

pUNO3-hTLR09a

货号： puno3-htlr9a      产品名称： pUNO3-hTLR09a   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

TLR9 Native Genes
Toll-Like Receptor 9 native genes in expression plasmid
Alias: CD289
TLR9 is expressed in the endoplasmic reticulum of resting cells in contrast to most TLRs that are located on the plasma membrane [1].
TLR9 recognizes specific unmethylated CpG-ODN sequences, that distinguish bacterial DNA from mammalian DNA. TLR9 engages an intracellular signaling pathway that involves MyD88 leading to NF-κB translocation [2].
TLR9 recognizes different CpG motifs; the optimal sequences being GTCGTT and GACGTT for human TLR9 and murine TLR9 respectively [3]. TLR9 binds directly to CpG DNA and recognizes specifically CpG DNA that is unmethylated and single stranded [4].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin or in pUNO3 expression plasmid selectable with Hygromycin or in pUNO1 expression plasmid selectable with Blasticidin.
Bovine TLR9 (pUNO1-bTLR09)
Genbank: EF076731
ORF Size: 3090 bp
Subclone: AgeI – NheI
Human TLR9 isoform 1 (pUNO1-hTLR09a)
ORF Size: 3099 bp
Subclone: MluI – NheI
Human TLR9 isoform 1 (pUNO3-hTLR09a)
ORF Size: 3099 bp
Mouse TLR9 (pUNO1-mTLR09)
ORF Size: 3099 bp
Subclone: AgeI – NheI
Pig TLR9 (pUNO1-pTLR09)
Genbank: AY859728.1
ORF Size: 3093 bp
Subclone: AgeI – NheI