标签归档：bcl

2040-5   BCl-2 Inhibitor GX15-070   品牌 Biovision

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BCl-2 Inhibitor GX15-070

货号： 2040-5      产品名称： BCl-2 Inhibitor GX15-070   品牌： Biovision 规格： 5 mg 3周到货 生化实验

BCl-2 Inhibitor GX15-070
A Bcl-2 inhibitor
Product Overview
Product Name: BCl-2 Inhibitor GX15-070
Alternate Name/Synonyms: (Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonate
Description: Cell-permeable. A small molecule pan–Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2–, Bcl-xl–, Bcl-w–, and Mcl-1–mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 803712-67-6
Molecular Formula: C₂₀H₁₉N₃O
Molecular Weight: 317.38
Purity: ≥98%
Solubility:DMSO (>80 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O
InChi: InChI=1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21,23H,1-3H3;1H3,(H,2,3,4)/b18-17-,19-10-;
InChi Key: ZVAGBRFUYHSUHA-LZOXOEDVSA-N
PubChem CID: 16681698
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

PC67-100UG   ANTI-BCL-X (AB-1) RABBIT PAB   品牌 Merck

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ANTI-BCL-X (AB-1) RABBIT PAB

货号： PC67-100UG      产品名称： ANTI-BCL-X (AB-1) RABBIT PAB   品牌： Merck 规格： *** 3周到货 生化实验

Anti-Bcl-xL (Ab-1) (201-216) Rabbit pAb
Recognizes the ~28 kDa Bcl-x protein in doxorubicin-treated MCF-7 cells.
产品信息
Host  Rabbit
Isotype  IgG
Immunogen  a synthetic peptide (PWIQENGGWDTFVELY) corresponding to amino acids 201-216 of human Bcl-x
Form  Liquid
Formulation  In 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.
Species reactivity  human, mouse, opossum, rat
Preservative  ≤0.1% sodium azide
Applications 
Frozen Sections
Immunoblotting (Western Blotting)
Paraffin Sections
Do not freeze  是的
Positive control  Doxorybicin-treated MCF-7 cells (see comments) or intestinal tissue
Negative control  Brain tissue
商店和运输信息
Storage  +2°C to +8°C
Ship  Blue Ice Only
Standard Handling

2°C – 8°C

PC68-100UG   ANTI-BCL-2 (AB-2) RABBIT PAB   品牌 Merck

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ANTI-BCL-2 (AB-2) RABBIT PAB

货号： PC68-100UG      产品名称： ANTI-BCL-2 (AB-2) RABBIT PAB   品牌： Merck 规格： *** 3周到货 生化实验

Anti-Bcl-2 (Ab-2) (20-34) Rabbit pAb
Recognizes the ~24-26 kDa Bcl-2 protein in MCF-7 cells, intestine, and lymph node tissue.
相关产品
PC68T  Anti-Bcl-2 (Ab-2) Rabbit pAb
产品信息
Host  Rabbit
Isotype  IgG
Immunogen  a synthetic peptide (HYKLSQRGYEWDAGD) corresponding to amino acids 20-34 of human Bcl-2
Form  Liquid
Formulation  In PBS.
Species reactivity  human, mouse, opossum
Preservative  ≤0.1% sodium azide
Applications 
Frozen Sections
Immunoblotting (Western Blotting)
Paraffin Sections
Avoid freeze/thaw  是的
Positive control  Human intestine or lymph node tissue or purified Bcl-2 (Cat. No. PF126)
Negative control  Brain tissue
商店和运输信息
Storage  -20°C
Ship  Blue Ice Only
Standard Handling

-20°C

PC89-100UG   ANTI-BCL-XS (AB-1) RABBIT PAB   品牌 Merck

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ANTI-BCL-XS (AB-1) RABBIT PAB

货号： PC89-100UG      产品名称： ANTI-BCL-XS (AB-1) RABBIT PAB   品牌： Merck 规格： *** 3周到货 生化实验

Anti-Bcl-xs (Ab-1) (119-131) Rabbit pAb
This product has been discontinued.
Recognizes the ~16 kDa Bcl-xs protein in doxorubicin-treated MCF-7 cells. Does not cross-react with Bcl-xL.
产品信息
Host  Rabbit
Isotype  IgG
Immunogen  a synthetic peptide (AYQSFEQDTFVEL) corresponding to amino acids 119-131 of human Bcl-xS
Form  Liquid
Formulation  In 0.05 M sodium phosphate buffer, 0.2% gelatin.
Species reactivity  human, not mouse, not rat
Preservative  ≤0.1% sodium azide
Applications 
Immunoblotting (Western Blotting)
Paraffin Sections
Do not freeze  是的
Positive control  Doxorubicin-induced MCF7 or HeLa cells or thymocytes
商店和运输信息
Storage  +2°C to +8°C
Ship  Blue Ice Only
Standard Handling

2°C – 8°C

PF126-50UG   BCL-2, C-TERMINAL TRUNCATED, RECOMB.,   品牌 Merck

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BCL-2, C-TERMINAL TRUNCATED, RECOMB.,

货号： PF126-50UG      产品名称： BCL-2, C-TERMINAL TRUNCATED, RECOMB.,   品牌： Merck 规格： *** 3周到货 生化实验

Bcl-2, C-Terminal Truncated, His•Tag®, Human, Recombinant, E. coli
Recombinant, human Bcl-2 without the 17 amino acid mitochondrial targeting sequence at the C-terminus, fused to a His•Tag® sequence, and expressed in E. coli. The truncated protein retains the ability to neutralize pro-apoptotic Bcl-2 family members.
产品信息
Form  Liquid
Formulation  In 100 mM KCl, 10 mM HEPES, 20% glycerol, pH 8.0.
Species reactivity  human
Molar mass  27000
Applications 
Avoid freeze/thaw  是的
Biological activity  EC50 = 100-300 nM based on its ability to inhibit 54 nM caspase-8-cleaved human Bid-mediated release of cytochrome c from isolated mouse liver mitochondria
Purity  ≥95% by SDS-PAGE
商店和运输信息
Storage  -20°C
Ship  Dry Ice Only
Standard Handling

-20°C

ST1662-100UG   ANTI-BCL9 MOUSE MAB (2D4)   品牌 Merck

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ANTI-BCL9 MOUSE MAB (2D4)

货号： ST1662-100UG      产品名称： ANTI-BCL9 MOUSE MAB (2D4)   品牌： Merck 规格： *** 3周到货 生化实验

Anti-BCL9 Mouse mAb (2D4)
Anti-β-cell CLL/Lymphoma 9
Recognizes the BCL9 protein in HeLa cells.
产品信息
Host  Mouse
Isotype  IgG1
Immunogen  A recombinant polypeptide corresponding to amino acids of 1036-1136 human BCL9, expressed as a GST fusion protein
Clone  2D4
Form  Liquid
Formulation  In PBS, pH 7.2.
Species reactivity  human
Preservative  None
Applications 
Enzyme-Linked Immunosorbent Assay
Immunoblotting (Western Blotting)
Immunocytochemistry
Avoid freeze/thaw  是的
Positive control  HeLa cells
商店和运输信息
Storage  -20°C
Ship  Blue Ice Only
Regulatory Review

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197345-50MG   BCL6 Inhibitor, 79-6   品牌 Merck

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BCL6 Inhibitor, 79-6

货号： 197345-50MG      产品名称： BCL6 Inhibitor, 79-6   品牌： Merck 规格： *** 3周到货 生化实验

BCL6 Inhibitor, 79-6
CID5721353, 2-((5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanedioic acid, B-Cell Lymphoma 6 Inhibitor
A cell-permeable oxindole compound that selectively inhibits the transcriptional repression activity of BCL6 (by ~70% at 50 µM in 293T-based reporter assays), but not that of three other BTB/POZ (bric-a-brac tramtrack broad complex/Poxvirus zinc finger) family members, Kaiso, HIC1, and PLZF, by direct BCL6 binding (Kd = 138 µM) via the BTB domain and blocking corepressor BBD- (BCL6 binding domain) mediated BCL6 interaction (IC50 = 212 µM & Ki = 147 µM in competitive binding against SMRT-BBD peptide), resulting in upregulation of BCL6 target genes in BCL-dependent DLBCL (diffuse large B cell lymphoma), but not BCL-independent Toledo and OCI-Ly4 cell lines. Shown to exhibit antiproliferative activity against DLBCL cell lines (IC50 from 24 to 936 µM) as well as primary human DLBCL cells in vitro and suppress BCL-dependent tumor growth in mice (<40% of control tumor size on day 9; 50 mg/kg/day via i.p.) in vivo.
产品信息
Form  Dark red powder
Molar mass  457.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C15H9BrN2O6S2
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling

2°C – 8°C

BML-SA239-0100   Bcl-2 (human), mAb (4D7)   品牌 Biomol

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Bcl-2 (human), mAb (4D7)

货号： BML-SA239-0100      产品名称： Bcl-2 (human), mAb (4D7)   品牌： Biomol 规格： 100 ug 3周到货 生化实验

Bcl-2 (human), mAb (4D7)
Product Specification
Clone:4D7
Host:Mouse
Isotype:IgG
Immunogen:Recombinant human Bcl-2α (aa 61-76).
UniProt ID:P10415
Application:Immunocytochemistry
Immunoprecipitation
Western Blot
Specificity:Recognizes human Bcl-2.
Purity Detail:Purified.
Long Term Storage:-20°C

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