标签归档：bace

PC529-100UG   ANTI-BACE (AB-2) RABBIT PAB   品牌 Merck

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ANTI-BACE (AB-2) RABBIT PAB

货号： PC529-100UG      产品名称： ANTI-BACE (AB-2) RABBIT PAB   品牌： Merck 规格： *** 3周到货 生化实验

Anti-BACE (Ab-2) (485-501) Rabbit pAb
Anti-β-Amyloid Precursor Protein Cleaving Enzyme, Anti-ASP2, Anti-β-Secretase
This product has been discontinued.
Recognizes the ~70-75 kDa BACE protein in human brain tissue extracts and mouse NIH3T3 cell lysates.
产品信息
Host  Rabbit
Isotype  IgG
Immunogen  a synthetic peptide (CLRQQHDDFADDISLLK) corresponding to amino acids 485-501 of human BACE
Form  Liquid
Formulation  In PBS.
Species reactivity  human, mouse
Preservative  ≤0.1% sodium azide
Applications 
Immunoblotting (Western Blotting)
Avoid freeze/thaw  是的
Positive control  Human brain tissue lysate
商店和运输信息
Storage  -20°C
Ship  Dry Ice Only
Standard Handling

-20°C

PF125-50UG   BACE-1, HIS-TAG, HUMAN, RECOMBINANT   品牌 Merck

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BACE-1, HIS-TAG, HUMAN, RECOMBINANT

货号： PF125-50UG      产品名称： BACE-1, HIS-TAG, HUMAN, RECOMBINANT   品牌： Merck 规格： *** 3周到货 生化实验

BACE1, His•Tag®, Human, Recombinant, NSO Cells
Recombinant, human BACE-1 (amino acids 1-460) fused at the C-terminus to a His•Tag® sequence and expressed in NSO cells. Supplied as a mixture of the ~68-70 kDa proenzyme and the ~65-67 kDa mature enzyme. BACE-1 is an aspartic protease that has been shown to cleave the amyloid precursor protein β site in the brain to generate the amyloid β peptide. MW: ~65-70 kDa under reducing conditions.
产品信息
Form  Lyophilized
Formulation  Lyophilized from sterile-filtered PBS.
Preservative  None
Specific activity  ≥1 pmol/min/µg protein
Activity  ≥1 pmol/min/µg as measured by the cleavage of 10 µM MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(DNP)-Arg-Arg-NH2 fluorescent substrate using 100 ng BACE-1 in 0.1 M sodium acetate (pH 4.0) at room temperature.
Purity  ≥90% by SDS-PAGE
Contaminants  Endotoxin: ≤1 EU/µg BACE-1
Solubility  H2O
商店和运输信息
Storage  -20°C
Ship  Blue Ice Only
Standard Handling

-20°C

BML-SA465-0100   BACE1, pAb   品牌 Biomol

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BACE1, pAb

货号： BML-SA465-0100      产品名称： BACE1, pAb   品牌： Biomol 规格： 100 ug 3周到货 生化实验

BACE1, pAb
BACE1 is expressed as a pre-pro-aspartyl protease, sometimes glycosylated, and inserted into the cell membrane as a dimer with catalytic domains in the cytosol. It is implicated in angiogenesis and Alzheimer’s disease.
Product Specification
Alternative Name:BACE, β-Secretase, β-Site APP cleaving enzyme 1, Memapsin-2, Aspartyl protease 2
Host:Rabbit
Immunogen:Synthetic peptide corresponding to the catalytic domain of human BACE1 (BACE, ß-secretase).
UniProt ID:P56817
Application:Western Blot
Specificity:Recognizes human, mouse and rat BACE1. Does not cross-react with BACE2.
Formulation:Liquid. In PBS containing 0.05% sodium azide and 50% glycerol.
Long Term Storage:-20°C

-20°C

BML-SE531-0050   BACE-1 (human) (recombinant)   品牌 Biomol

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BACE-1 (human) (recombinant)

货号： BML-SE531-0050      产品名称： BACE-1 (human) (recombinant)   品牌： Biomol 规格： 50 ug 3周到货 生化实验

BACE1 (human), (recombinant)
Product Specification
Alternative Name:β-Secretase, Memapsin-2, Asp-2, Beta-site APP-cleaving enzyme-1
MW:45 kDa
Source:Produced in E. coli. Active soluble BACE1.
UniProt ID:P56817
Application:Study of enzyme kinetics, cleave target substrates, and screen for inhibitors.
Long Term Storage:-80°C
Miscellaneous/General:BACE1 is an aspartic protease involved in Alzheimer’s disease and cancer.

-80°C

10064H02H25   RECOM HU BACE1 (HIGG1-FC) ACTI   品牌 Invitrogen

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RECOM HU BACE1 (HIGG1-FC) ACTI

货号： 10064H02H25      产品名称： RECOM HU BACE1 (HIGG1-FC) ACTI   品牌： Invitrogen 规格： 25UG 三周到货 生化试验

BACE1 Recombinant Human Protein, hIgG1-Fc tag
Beta-secretase 1, recombinant human protein is supplied as a lyophilized powder. It is suitable for use in performing enzymatic assays, and cell biology research applications. It can also be used as a protein standard.
This recombinant protein was expressed as a secreted protein from a DNA sequence encoding the extracellular domain (Met 1-Thr 457) of human BACE1 (NP_036236.1) fused to the Fc region of human IgG1 at the C-terminus.
Activity: Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >0.5 pmoles/min/µg.
Formulation: Lyophilized in PBS, pH 7.4, 5% Mannitol, 5% Trehalose, and 0.02% Tween 80.
Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/ml or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.
Form: Lyophilized 
Purity: ≥ 85% by SDS-PAGE 
Gene ID: 23621 
Species: Human 
Expression: Mammalian 
Gene Symbol: BACE1 
Gene Aliases: BACE1, ASP2, BACE, HSPC104, FLJ90568, KIAA1149 
Product Size: 5 x 5 µg 
Protein Form: Recombinant,
Truncated 
Protein Family: Other Proteins 
Endotoxin Level: < 1 EU/µg 
Protein Subtype: Proteases 
Molecular Weight: 75 kDa 
Research Category: Neurobiology 
Protein Tag or Fusion: IgG1 Fc Tag 
Validated Application: Assay Standard 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at -20 to -70 °C

10064H02H250   RECOM HU BACE1 (HIGG1-FC) ACTI   品牌 Invitrogen

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RECOM HU BACE1 (HIGG1-FC) ACTI

货号： 10064H02H250      产品名称： RECOM HU BACE1 (HIGG1-FC) ACTI   品牌： Invitrogen 规格： 250UG 三周到货 生化试验

BACE1 Recombinant Human Protein, hIgG1-Fc tag
Beta-secretase 1, recombinant human protein is supplied as a lyophilized powder. It is suitable for use in performing enzymatic assays, and cell biology research applications. It can also be used as a protein standard.
This recombinant protein was expressed as a secreted protein from a DNA sequence encoding the extracellular domain (Met 1-Thr 457) of human BACE1 (NP_036236.1) fused to the Fc region of human IgG1 at the C-terminus.
Activity: Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >0.5 pmoles/min/µg.
Formulation: Lyophilized in PBS, pH 7.4, 5% Mannitol, 5% Trehalose, and 0.02% Tween 80.
Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/ml or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.
Form: Lyophilized 
Purity: ≥ 85% by SDS-PAGE
Gene ID: 23621
Species: Human 
Expression: Mammalian 
Gene Symbol: BACE1 
Gene Aliases: BACE1, ASP2, BACE, HSPC104, FLJ90568, KIAA1149 
Product Size: 5 x 50 µg 
Protein Form: Recombinant,
Truncated 
Protein Family: Other Proteins 
Endotoxin Level: < 1 EU/µg 
Protein Subtype: Proteases 
Molecular Weight: 75 kDa 
Research Category: Neurobiology 
Protein Tag or Fusion: IgG1 Fc Tag 
Validated Application: Assay Standard 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at -20 to -70 °C

10064H02H5   RECOM HU BACE1 (HIGG1-FC) ACTI   品牌 Invitrogen

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RECOM HU BACE1 (HIGG1-FC) ACTI

货号： 10064H02H5      产品名称： RECOM HU BACE1 (HIGG1-FC) ACTI   品牌： Invitrogen 规格： 5 UG 三周到货 生化试验

BACE1 Recombinant Human Protein, hIgG1-Fc tag
Beta-secretase 1, recombinant human protein is supplied as a lyophilized powder. It is suitable for use in performing enzymatic assays, and cell biology research applications. It can also be used as a protein standard.
This recombinant protein was expressed as a secreted protein from a DNA sequence encoding the extracellular domain (Met 1-Thr 457) of human BACE1 (NP_036236.1) fused to the Fc region of human IgG1 at the C-terminus.
Activity: Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >0.5 pmoles/min/µg.
Formulation: Lyophilized in PBS, pH 7.4, 5% Mannitol, 5% Trehalose, and 0.02% Tween 80.
Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/ml or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.
Form: Lyophilized 
Purity: ≥ 85% by SDS-PAGE 
Gene ID: 23621 
Species: Human 
Expression: Mammalian 
Gene Symbol: BACE1 
Gene Aliases: BACE1, ASP2, BACE, HSPC104, FLJ90568, KIAA1149 
Product Size: 5 µg 
Protein Form: Recombinant,
Truncated 
Protein Family: Other Proteins 
Endotoxin Level: < 1 EU/µg 
Protein Subtype: Proteases 
Molecular Weight: 75 kDa 
Research Category: Neurobiology 
Protein Tag or Fusion: IgG1 Fc Tag 
Validated Application: Assay Standard 
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at -20 to -70 °C

10064H02H50   RECOM HU BACE1 (HIGG1-FC) ACTI   品牌 Invitrogen

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RECOM HU BACE1 (HIGG1-FC) ACTI

货号： 10064H02H50      产品名称： RECOM HU BACE1 (HIGG1-FC) ACTI   品牌： Invitrogen 规格： 50UG 三周到货 生化试验

BACE1 Recombinant Human Protein, hIgG1-Fc tag
Beta-secretase 1, recombinant human protein is supplied as a lyophilized powder. It is suitable for use in performing enzymatic assays, and cell biology research applications. It can also be used as a protein standard.
This recombinant protein was expressed as a secreted protein from a DNA sequence encoding the extracellular domain (Met 1-Thr 457) of human BACE1 (NP_036236.1) fused to the Fc region of human IgG1 at the C-terminus.
Activity: Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK(Dpn)RR-NH2. The specific activity is >0.5 pmoles/min/µg.
Formulation: Lyophilized in PBS, pH 7.4, 5% Mannitol, 5% Trehalose, and 0.02% Tween 80.
Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/ml or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.
Form: Lyophilized 
Purity: ≥ 85% by SDS-PAGE 
Gene ID: 23621 
Species: Human 
Expression: Mammalian 
Gene Symbol: BACE1 
Gene Aliases: BACE1, ASP2, BACE, HSPC104, FLJ90568, KIAA1149 
Product Size: 50 µg 
Protein Form: Recombinant,
Truncated 
Protein Family: Other Proteins 
Endotoxin Level: < 1 EU/µg 
Protein Subtype: Proteases 
Molecular Weight: 75 kDa 
Research Category: Neurobiology 
Protein Tag or Fusion: IgG1 Fc Tag 
Validated Application: Assay Standard
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at -20 to -70 °C

BML-SE550-0010   BACE2 (soluble) (human), (recombinant) (His-tag)   品牌 Biomol

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BACE2 (soluble) (human), (recombinant) (His-tag)

货号： BML-SE550-0010      产品名称： BACE2 (soluble) (human), (recombinant) (His-tag)   品牌： Biomol 规格： 10 ug 3周到货 生化实验

BACE2 (soluble) (human), (recombinant) (His-tag)
Highly active
Recombinant soluble BACE2, cloned from human cDNA, secreted as zymogen from insect cells, purified using a C-terminal His-tag, and cleaved to the mature active form. BACE2 is an aspartic protease found in both transmembrane and soluble forms. It is related to, and possesses an overlapping substrate profile with, BACE1. It is likely involved in Alzheimer’s disease, and implicated in other neurological, pancreatic, and muscle pathologies.
Product Specification
Alternative Name:β-Secretase 2, β-Site APP-cleaving enzyme 2, Memapsin-1, ASP-1
Sequence:aa Ala21-Pro466.
MW:~45kDa (calculated); ~48kDa (doublet by SDS-PAGE)
Source:Produced in insect cells.
EC:3.4.23.45
UniProt ID:Q9Y5Z0
Formulation:Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 20% glycerol.
Purity:≥80% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Specific Activity:≥20 U/µg enzyme. One unit will hydrolyze one pmole Mca-KPLGL-Dpa-AR substrate (Prod. No. BML-P276) (10µM) per minute at 37°C, in 50mM NaOAc, pH 4.5, 1M sodium chloride.
Application:Study enzyme kinetics, cleave target substrates, and screen for BACE2 inhibitors or BACE1 inhibitor selectivity.
Long Term Storage:-80°C
Use/Stability:BACE2 is stable after 5 freeze-thaws at 0.3-0.4 µg/µl; freeze-thaw stability of more dilute preparations has not been tested and could lead to loss of activity.

-80°C