Anti-p38/SAPK2A

货号： ABS29      产品名称： Anti-p38/SAPK2A   品牌： Millipore 规格： *** 三周到货 生化实验

Anti-p38/SAPK2A
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Eq, Rhesus Macaque  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-p38/SAPK2A Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes p38/SAPK2A at the protein kinase domain.
Molecular Weight:
~41 kDa observed. An uncharacterized band appears at ~35 kDa in some lysates.
Epitope:
Protein kinase domain
Immunogen:
KLH-conjugated linear peptide corresponding to the protein kinase domain of human p38/SAPK2A.
Background Information:
The p38 family refers to the SAPK2/3 Kinases (Stress-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation.
View All »
Species Reactivity:
Human
Mouse
Rat
Horse
Rhesus Macaque
View All »
Species Reactivity Note:
Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Equine and Rhesus Macaque based on 100% sequence homology.
Control:
Human brain tissue lysate
Quality Assurance:
Evaluated by Western Blot in human brain tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected p38/SAPK2A on 10 µg of human brain tissue lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q15759
Entrez Gene Number:
NP_002742
Gene Symbol:
MAPK11
PRKM11
SAPK2
Alternate Names:
Mitogen-activated protein kinase 11
MAP kinase 11
MAPK 11
Mitogen-activated protein kinase p38 beta
MAP kinase p38 beta
p38b
Stress-activated protein kinase 2
p38-2
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/C 2-8℃