标签： sam

07-415   ANTI-SAM 68 200UL   品牌 Millipore

ANTI-SAM 68 200UL

货号： 07-415      产品名称： ANTI-SAM 68 200UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Sam 68 Antibody
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REFERENCES
A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines.
Chen, T, et al. (1999) Mol. Biol. Cell, 10: 3015-33 (1999)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  IP, WB, ICC Rabbit Serum Polyclonal Antibody
Description:
Anti-Sam 68 Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Sam 68
Molecular Weight:
68kDa
Immunogen:
Peptide corresponding to residues 331-348 of human Sam 68
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
routinely evaluated by immunoblot in RIPA lysates from HeLa cells
Purification Method:
Antiserum
Presentation:
0.1M Trisglycine,pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
Q07666
Entrez Gene Number:
NM_006559
Gene Symbol:
KHDRBS1
Sam68
FLJ34027
SAM68
p68
p62
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Immunocytochemistry
UniProt Summary:
FUNCTION: SwissProt: Q07666 # Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.
SIZE: 443 amino acids; 48227 Da
SUBUNIT: Self-associates to form homo-oligomers when bound to RNA, oligomerization appears to be limited when binding to proteins. Interacts with CBL, KHDRBS3, LCK, GRB2, JAK3, PIK3R1, PLCG1, PTPN6, RASA1, and STAT3. Interacts with PRMT1. Binds the WW domains of WBP4/FBP21, FNBP4/FBP30 and the SH3 domain of FYN through the Arg/Gly-rich-flanked Pro-rich regions (By similarity).
SUBCELLULAR LOCATION: Nucleus. Membrane.
TISSUE SPECIFICITY: Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.
DEVELOPMENTAL STAGE: Isoform 3 is only expressed in growth- arrested cells.
DOMAIN: SwissProt: Q07666 The KH domain is required for binding to RNA (By similarity). & The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methlylation on these motifs can modulate protein-protein interactions (By similarity).
PTM: Tyrosine phosphorylated by several non-receptor tyrosine kinases, for example LCK, FYN and JAK3. Negatively correlates with ability to bind RNA but required for many interactions with proteins. & Acetylated. Positively correlates with ability to bind RNA. & Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30. & Arg-291, Arg-331 and Arg-346 are found to be also dimethylated, probably to asymmetric dimethylarginine.
SIMILARITY: Belongs to the KHDRBS family. & Contains 1 KH domain.
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Brand Family:
Upstate
Product Name:
Anti-Sam 68 Antibody
Antibody Type:
Pol -20℃