标签： oxytocin

500106-2MG   Oxytocin Receptor Antagonist, MSC1630296   品牌 Merck

Oxytocin Receptor Antagonist, MSC1630296

货号： 500106-2MG      产品名称： Oxytocin Receptor Antagonist, MSC1630296   品牌： Merck 规格： PC 3周到货 生化实验

Oxytocin Receptor Antagonist, MSC1630296
OT-R Antagonist, 3-(4-(N-(4-chlorophenyl)-N-(2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)ethyl)sulfamoyl)phenyl)-N-(3-(dimethylamino)propyl)propanamide, fumarate salt 
A tertiary sulfonamide-based compound that acts as a high-affinity oxytocin (OT) receptor-selective antagonist (Ki = 650 and 670 pM in 125I-OVTA-competitive binding assays using human and rat OT-R, respectively), while displaying 65-, 245-, and 23,000-fold reduced affinity, respectively, toward human vassopressin receptors V1a, V2, and V1b. Shown to effectively inhibit OT- (10 nM) induced Ca2+ mobilization in hOT-R-expressing HEK293-EBNA cells (IC50 = 14 nM) in vitro and OT-stimulated uterine contractions in rats (1.4 -10 mg/kg p.o. or 30 mg/kg p.o.) in vivo. Product is supplied as a fumarate salt for enhanced aqueous solubility (20 and 10 mg/ml, respectively, in water and HBSS).
产品信息
Form  Brown solid
Primary Target  Oxytocin receptor
Primary Target Ki  0.65 nM
Molar mass  741.2
Protect from Light  是的
Packaged under inert gas  是的
Reversible  是的
Purity  ≥93% by HPLC
Solubility  DMSO
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling

2°C – 8°C

ABN297   Anti-Oxytocin receptor   品牌 Millipore

Anti-Oxytocin receptor

货号： ABN297      产品名称： Anti-Oxytocin receptor   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Oxytocin receptor
Species Reactivity Key Applications Host Format Antibody Type
H, M  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Oxytocin receptor Antibody
Molecular Weight:
~45/65 kDa observed The calculated molecular weight of this protein is 43 kDa. However, this protein has been observed at ~60-70 kDa due to glycoslyatation (Zhong, M.m et al. (2012). Molecular Cancer Research. 1-25). Uncharacterized band(s) may appear in some lysates.
Epitope:
Cytoplasmic domain
Immunogen:
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Oxytocin receptor.
Background Information:
Oxytocin is a cyclic 9 amino acid peptide that differs from vasopressin in 2 amino acids. Despite the close similarities in sequence, oxytocin and vasopressin have different biological activities and bind to distinct G protein-coupled receptors. The oxytocin receptor, OT, couples primarily to Gq/11 to mobilize intracellular calcium. In female reproduction, oxytocin promotes uterine contraction and lactation; oxytocin is the most commonly used drug for induction of labor, whereas an oxytocin antagonist, atosiban, is under investigation to suppress preterm labor. Oxytocin/OT interaction in the CNS also plays an important role in stress, male and female sexual response, and sociality.
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Species Reactivity:
Human
Mouse
Quality Assurance:
Evaluated by Western Blotting in MCF7 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Oxytocin receptor in 10 µg of MCF7 cell lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P30559
Entrez Gene Number:
NP_000907
Gene Symbol:
OXTR
Alternate Names:
Oxytocin receptor
OT-R
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Product Name:
Anti-Oxytocin receptor
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit
Applications:
Anti-Oxytocin receptor Antibody is a highly specific rabbit polyclonal antibody, that targets Oxytocin Receptor & has been tested in western blotting.

2-8℃

O9497-1 g   Oxytocin   品牌 LKT

Oxytocin

货号： O9497-1 g      产品名称： Oxytocin   品牌： LKT 规格： 1 g 三周到货 生化试验

Oxytocin      
Description
A hormone found in mammals that is a neurotransmitter in the brain. It is involved in reproduction.
Specifications 
Cas No. 50-56-6
Product ID  O9497
Product Name  Oxytocin
Chemical Name  L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L- asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic (1-6)-disulfide
Synonym Ocytocin; Interocine-S; Perlacton; Pitocin; Syntocinon; Orasthin; Oxystin; Partocon.
Formula Wt. 1007.2
Purity ≥95% 
Solubility Soluble in water, 1-butanol or 2-butanol.
Store Temp +4oC
 

+4oC

AB911   OXYTOCIN, RBX-100UL   品牌 Millipore

OXYTOCIN, RBX-100UL

货号： AB911      产品名称： OXYTOCIN, RBX-100UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Oxytocin Antibody
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REFERENCES
Paternal deprivation alters play-fighting, serum corticosterone and the expression of hypothalamic vasopressin and oxytocin in juvenile male mandarin voles.
Jianli Wang,Fadao Tai,Xingfu Yan,Peng Yu (2012) Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology.198
The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats.
C Hicks,W Jorgensen,C Brown,J Fardell,J Koehbach,C W Gruber,M Kassiou,G E Hunt,I S McGregor (2012) Journal of neuroendocrinology.24
MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635.
Glenn E Hunt,Iain S McGregor,Jennifer L Cornish,Paul D Callaghan (2011) Brain research bulletin.86
Activation of different neuronal phenotypes in the rat brain induced by liver ischemia–reperfusion injury: dual Fos/neuropeptide immunohistochemistry.
J Bundzikova,Z Pirnik,L Lackovicova,B Mravec,A Kiss (2011) Cellular and molecular neurobiology.31
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Species Reactivity Key Applications Host Format Antibody Type
H, Ht, M, R, Rb, Sh  DB, ICC, IH(P), RIA Rabbit Serum Polyclonal Antibody
Description:
Anti-Oxytocin Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Recognizes Oxytocin. Less than 1% cross-reactivity with arginine vasopressin.
Immunogen:
Synthetic oxytocin (Sigma) conjugated to thyroglobulin.
Species Reactivity:
Human
Hamster
Mouse
Rat
Rabbit
Sheep
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Application Notes:
Immunohistochemistry: 1:5,000-1:10,000 (18-24 hour incubation) on formalin, Bouin’s or Zamboni’s fixed tissue. Will react on paraffin embedded tissue.
Immunocytochemistry: 1:10,000 on fetal rat neurons.
Dot Blot: 1:1000
RIA
Optimal working dilutions must be determined by the end user.
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Control:
Pituitary Gland
Purification Method:
Unpurified
Presentation:
Neat rabbit antisera. Liquid. Contains no preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
P01178
Entrez Gene Number:
NM_000915.2
Gene Symbol:
OXT
MGC126890
MGC126892
OT
OT-NPI
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Dot Blot
Immunocytochemistry
Immunohistochemistry (Paraffin)
Radioimmunoassay
Entrez Gene Summary:
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transpo -20℃