Anti-MSX1 (Msh homeobox 1-like protein)

货号： ABD10      产品名称： Anti-MSX1 (Msh homeobox 1-like protein)   品牌： Millipore 规格： *** 三周到货 生化实验

Anti-MSX1 (Msh homeobox 1-like protein)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-MSX1 (Msh homeobox 1-like protein) Antibody
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Molecular Weight:
~31 kDa observed. An uncharacterized band appears at ~65 kDa in some lysates.
Immunogen:
Linear peptide corresponding to human MSX1.
Background Information:
The Msx genes are a family of homeobox genes related to the Drosophila msh (muscle segment homeobox)-like gene family. It may play a role in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations associated with MSX1 are tooth agenesis selective type 1, Witkop syndrome, and cleft lip.
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Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology.
Control:
Human fetal skeletal muscle tissue lysate
Quality Assurance:
Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected MSX1 on 10 µg of human fetal skeletal muscle tissue lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P28360
Entrez Gene Number:
NP_002439
Gene Symbol:
MSX1
HOX7
Alternate Names:
Homeobox protein MSX-1
Homeobox protein Hox-7
Msh homeobox 1-like protein
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq].
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UniProt Summary:
FUNCTION: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICTY: Expressed in the developing nail bed mesenchyme.
PTM: Sumoylated by PIAS1, desumoylated by SENP1 (By similarity).
INVOLVEMENT IN DISEASE: Defects in MSX1 are the cause of tooth agenesis selective type 1 (STHAG1) [MIM:106600]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided i 2-8℃