标签归档：mct

AB3549P   MCT8 (MS), RBX-50UG   品牌 Millipore

发表于由

MCT8 (MS), RBX-50UG

货号： AB3549P      产品名称： MCT8 (MS), RBX-50UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Monocarboxylate Transporter 8 Antibody
Recommended Replacement for: AB3324P
Close
REFERENCES
The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.
Halestrap, A P and Price, N T (1999) Biochem. J., 343 Pt 2: 281-99 (1999)
Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past
Price NT et al. (1998) Biochem. J., 329(Pt 2):321-328 (1998)
Species Reactivity Key Applications Host Format Antibody Type
M  ELISA, WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Monocarboxylate Transporter 8 Antibody
Replaces:
AB3324P
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Recognizes mouse Monocarboxylate Transporter 8.
Immunogen:
A 19 amino acid peptide sequence within the cytoplasmic, C-terminus of mouse MCT8. The immunogen sequence is 94% conserved in rat and 89% in human MCT8 and shows no significant sequence homology with other MCT family members.
Background Information:
MCT8 is an integral membrane protein that is associated with the plasma membrane. A member of the Major Facilitator Superfamily, MCT8 serves as a proton-linked monocarboxylate transporter that catalyzes the rapid transport of monocarboxylates and ketone bodies across the plasma membrane. Expression of MCT8 is greatest in liver and kidney.
View All »
Species Reactivity:
Mouse
Application Notes:
Western blot: 1-5 μg/mL using ECL.
ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide (Catalog number AG202) per well.
Optimal working dilutions must be determined by the end user.
Control:
POSITIVE CONTROL: Liver or kidney extracts
Presentation:
Affinitypurified immunoglobulin presented as a liquid in PBS with 0.1% BSA.
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
UniProt Number:
P36021
Entrez Gene Number:
NM_006517.2
Gene Symbol:
SLC16A2
DXS128E
DXS128
MCT8
AHDS
XPCT
MCT7
View All »
Alternate Names:
MCT8; X-linked PEST-containing Transporter
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
ELISA
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: P36021 # Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).
SIZE: 539 amino acids; 59511 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Highly expressed in liver and heart.
DISEASE: SwissProt: P36021 # Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency) [MIM:300523]. MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormon -20℃