Anti-Galectin-3

货号： AB10541      产品名称： Anti-Galectin-3   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Galectin-3
Species Reactivity Key Applications Host Format Antibody Type
H, Rhesus Macaque  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Galectin-3 Antibody
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Specificity:
This antibody recognizes the Pro64 mutation domain of Galectin-3. It is equally specific for wild-type or mutant His64 Galectin-3.
Molecular Weight:
~33 kDa observed
Epitope:
Pro64 mutation domain
Immunogen:
KLH-conjugated linear peptide corresponding to the Pro64 mutation domain of human Galectin-3.
Background Information:
Galectin-3 belongs to the galectin gene family, which is defined by the specificity of a carbohydrate recognition domain (CRD) for Gal/Lac. Galectin-3 expression is usually elevated in a wide range of neoplastic cell types. The galectin CRD consists of 135 amino acids. Galectin-3 is known to play a role in tumor development, apoptosis, and cell cycle progression.
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Species Reactivity:
Human
Rhesus Macaque
Species Reactivity Note:
Demonstrated to react with Human.
Predicted to react with Rhesus Macaque based on 100% sequence homology.
Control:
MG-63 cell lysate
Quality Assurance:
Evaluated by Western Blot in MG-63 cell lysate.
Western Blot Analysis: A 1:250 dilution of this antibody detected Galectin-3 in 10 µg of MG-63 cell lysate.
Purification Method:
Affinity Purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P17931
Entrez Gene Number:
NP_002297
Gene Symbol:
LGALS3
MAC2
Alternate Names:
Galectin-3
Gal-3
35 kDa lectin
Carbohydrate-binding protein 35
CBP 35
Galactose-specific lectin 3
Galactoside-binding protein
GALBP
IgE-binding protein
L-31
Laminin-binding protein
Lectin L-29
Mac-2 antigen
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.
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UniProt Summary:
FUNCTION: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory re 2-8℃