标签归档：cgmp

ADI-900-014   Direct cGMP ELISA kit   品牌 Enzo

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Direct cGMP ELISA kit

货号： ADI-900-014      产品名称： Direct cGMP ELISA kit   品牌： Enzo 规格： 1 x 96 wells 3周到货 生化实验

Direct cGMP ELISA kit
Most sensitive (0.025 pmol/ml) colorimetric kit for intracellular cGMP quantification.
Replaces Prod. #: BML-AK300
Alternative size available: ADI-901-014 (5×96 wells)
•Easy-to-use – pre-coated plates and liquid color-coded reagents reduce errors
•Sensitive – optional acetylation protocol increases sensitivity 10-fold (0.025 pmol/ml)
•Trusted – regularly cited in peer-reviewed publications
•Higher throughput – obtain results from up to 39 samples in duplicate per 96 well plate
•Simple – efficient and well-established sample handling protocols
•Reliable – consistent lot-to-lot performance
Product Specification
Alternative Name: cyclic GMP 
Sensitivity: (non-acetylated) 0.604 pmol/ml; (acetylated) 0.025 pmol/ml (range (non-acetylated) 0.8 – 500 pmol/ml; (acetylated) 0.08 – 50 pmol/ml) 
Assay Time: 2 hours  
Application: For the quantitative determination of cGMP in cell lysates and tissue from any species. Cited sample types include cerebral spinal fluid (ref. 1) and microdialysate (ref. 2).  
Crossreactivity: cyclic GMP (100%) and <0.001% GMP, GTP, cyclic AMP, AMP, ATP, cyclic UMP, CTP
Use/Stability: Store all components at 4°, except standard and conjugate at -20°. 
Kit/Set Contains: GxR IgG Microtiter plate, Conjugate, Antibody, 0.1M HCl, Neutralizing reagent, Wash buffer concentrate, Standard, pNpp Substrate, Stop solution, Acetic anhydride, Triethylamine
Miscellaneous/General: Cyclic GMP (cGMP), which has been shown to be present at levels typically 10-100 fold lower than cAMP, is formed by the action of the enzyme guanylate cyclase on GTP. Some hormones, such as Acetylcholine, Insulin, and Oxytocin, as well as certain other chemicals like Serotonin and Histamine cause an increase in cGMP levels. Stimulators of guanylate cyclase such as the vasodilators nitroprusside, nitroglycerin, sodium nitrate, and nitric oxide (NO) also stimulate cGMP levels.

4°

10010109-100   8-DY547-cGMP   品牌 Cayman

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8-DY547-cGMP

货号： 10010109-100      产品名称： 8-DY547-cGMP   品牌： Cayman 规格： 100 碌g 3周

8-DY547-cGMP
Cayman Chemical Item Number 10010109
Description Through activation by the binding of cyclic nucleotides, cyclic nucleotide-gated (CNG) ion channels mediate sensory signal transduction in photoreceptors and olfactory cells. 8-DY547-cGMP is a fluorescently-labeled cyclic nucleotide that can be used to study CNGA2 channel activation. 8-DY547-cGMP and cGMP open the channel with equal efficiency and control of the channel activity is rapid and reversible. The difference in fluorescence (ΔF) can be determined by using DY647.1↗
Formal Name 1-​ethyl-​2-​((4E)-​4-​(1-​ethyl-​3-​(4-​(2-​(methylthio)ethylamino)-​4-​oxobutyl)-​5-​sulfonatoindolin-​2-​ylidene)but-​2-​en-​2-​yl)-​3,​3-​dimethyl-​3H-​indolium-​5-​sulfonate-​guanosine-​3′,​5′-​cyclic monophosphate,​ disodium salt
Molecular Formula C42H55N8O14PS3 · 2Na
Formula Weight 1069.1
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CC[N+]​(C(C=C(S(=O)​([O-]​)​=O)​C=C1)​=C1C2(C)​C)​=C2/C=C/C=C3C(CCCC(NCCSC4NC(C(NC(N)​=N5)​=O)​C5N4C6OC(COP(O7)​([O-]​)​=O)​C7C6O)​=O)​(C)​C(C=C(S(=O)​([O-]​)​=O)​C=C8)​C8N/3CC.[Na+]​.[Na+]​ 
InCHI Code 1S/C42H57N8O14PS3.2Na/c1-6-48-27-16-14-23(67(56,57)​58)​20-26(27)​42(5,31(48)​11-8-10-30-41(3,4)​25-15-13-24(68(59,60)​61)​21-28(25)​49(30)​7-2)​17-9-12-32(51)​44-18-19-66-40-45-33-36(46-39(43)​47-37(33)​53)​50(40)​38-34(52)​35-29(63-38)​22-62-65(54,55)​64-35;;/ 
InCHI Key VKTWASDKFOZMCE-UHFFFAOYSA-L

-20°C

10010109-50   8-DY547-cGMP   品牌 Cayman

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8-DY547-cGMP

货号： 10010109-50      产品名称： 8-DY547-cGMP   品牌： Cayman 规格： 50 碌g 3周

8-DY547-cGMP
Cayman Chemical Item Number 10010109
Description Through activation by the binding of cyclic nucleotides, cyclic nucleotide-gated (CNG) ion channels mediate sensory signal transduction in photoreceptors and olfactory cells. 8-DY547-cGMP is a fluorescently-labeled cyclic nucleotide that can be used to study CNGA2 channel activation. 8-DY547-cGMP and cGMP open the channel with equal efficiency and control of the channel activity is rapid and reversible. The difference in fluorescence (ΔF) can be determined by using DY647.1↗
Formal Name 1-​ethyl-​2-​((4E)-​4-​(1-​ethyl-​3-​(4-​(2-​(methylthio)ethylamino)-​4-​oxobutyl)-​5-​sulfonatoindolin-​2-​ylidene)but-​2-​en-​2-​yl)-​3,​3-​dimethyl-​3H-​indolium-​5-​sulfonate-​guanosine-​3′,​5′-​cyclic monophosphate,​ disodium salt
Molecular Formula C42H55N8O14PS3 · 2Na
Formula Weight 1069.1
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CC[N+]​(C(C=C(S(=O)​([O-]​)​=O)​C=C1)​=C1C2(C)​C)​=C2/C=C/C=C3C(CCCC(NCCSC4NC(C(NC(N)​=N5)​=O)​C5N4C6OC(COP(O7)​([O-]​)​=O)​C7C6O)​=O)​(C)​C(C=C(S(=O)​([O-]​)​=O)​C=C8)​C8N/3CC.[Na+]​.[Na+]​ 
InCHI Code 1S/C42H57N8O14PS3.2Na/c1-6-48-27-16-14-23(67(56,57)​58)​20-26(27)​42(5,31(48)​11-8-10-30-41(3,4)​25-15-13-24(68(59,60)​61)​21-28(25)​49(30)​7-2)​17-9-12-32(51)​44-18-19-66-40-45-33-36(46-39(43)​47-37(33)​53)​50(40)​38-34(52)​35-29(63-38)​22-62-65(54,55)​64-35;;/ 
InCHI Key VKTWASDKFOZMCE-UHFFFAOYSA-L

-20°C

09-101   cGMP, Rb X-50μL   品牌 Millipore

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cGMP, Rb X-50μL

货号： 09-101      产品名称： cGMP, Rb X-50μL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-cGMP (cyclic GMP) Antibody
Species Reactivity Key Applications Host Format Antibody Type
A  ELISA, IHC, RIA Rabbit Serum Polyclonal Antibody
Description:
Anti-cGMP (cyclic GMP) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes cGMP. Very little cross reactivity to cAMP based on ELISA.
Immunogen:
2 Monosuccinyl cyclic GMP conjugated to KLH
Isotype:
IgG
Species Reactivity:
All
Quality Assurance:
Routinely evaluated by ELISA
Purification Method:
Serum
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q13976
Entrez Gene Number:
NM_001098512.1
NM_006258.2
Gene Symbol:
PRKG1
cGKI-beta
FLJ36117
PRKG1B
PGK
cGKI-BETA
PRKGR1A
cGKI-alpha
PRKGR1B
cGKI
MGC71944
DKFZp686K042
OTTHUMP00000061216
CGKI
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Alternate Names:
Guanosine 3′, 5′-cyclic monophosphate
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
ELISA
Immunohistochemistry
Radioimmunoassay
UniProt Summary:
SIZE: 686 amino acids; 77804 Da
SUBUNIT: Antiparallel homodimer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with MRVI1.
DOMAIN:SwissProt: P14619
SIMILARITY: SwissProt: P14619 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 cyclic nucleotide-binding domains. & Contains 1 protein kinase domain. | Q13976 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 cyclic nucleotide-binding domains. & Contains 1 protein kinase domain.
MISCELLANEOUS: Exhibit a substrate specificity similar but not identical to that of CAK.
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Brand Family:
Upstate
Product Name:
Anti-cGMP (cyclic GMP) Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
50 µL
Format:
Serum
Host:
Rabbit
Applications:
Anti-cGMP (cyclic GMP) Antibody detects level of cGMP (cyclic GMP) & has been published & validated for use in ELISA, IH, RIA.

-20℃