标签： agk

1651-10   SIRT2 Inhibitor, AGK2   品牌 Biovision

SIRT2 Inhibitor, AGK2

货号： 1651-10      产品名称： SIRT2 Inhibitor, AGK2   品牌： Biovision 规格： 10 mg 3周到货 生化实验

SIRT2 Inhibitor, AGK2
Product Overview
Product Name: SIRT2 Inhibitor, AGK2
Alternate Name/Synonyms: AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
Description: A potent inhibitor of sirtuin 2 (SIRT2) (IC₅₀ = 3.5 µM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 304896-28-4
Molecular Formula: C₂₃H₁₃Cl₂N₃O₂
Molecular Weight: 434.27
Purity: ≥95% by HPLC
Solubility:DMSO
Storage Temp.: +4°C
Shipping Conditions: RT
Handling: Protect from air and light
SMILES: C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N
InChi: InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
InChi Key: SVENPFFEMUOOGK-SDNWHVSQSA-N
PubChem CID: 2130404
MDL Number: MFCD01909444
USAGE: For Research Use Only! Not For Use in Humans.

+4°C

ALX-270-484-M001   AGK2   品牌 Alexis

AGK2

货号： ALX-270-484-M001      产品名称： AGK2   品牌： Alexis 规格： 1 mg 3周到货 生化实验

AGK2
SIRT2 inhibitor
Potent, selective and cell permeable inhibitor of sirtuin 2 (SIRT2) (IC50=3.5μM). Rescues α-synuclein-mediated toxicity. Modifies inclusion morphology in a cellular model of Parkinson’s disease. Protects against dopaminergic cell death. Leads to an increase in acetylated tubulin.
Product Specification
Alternative Name: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Formula: C23H13Cl2N3O2
MW: 434.3
CAS: 304896-28-4
Purity: ≥95%
Identity: Identity determined by MS, 1H- and 13C-NMR.
Appearance: Yellow solid.
Solubility: Soluble in DMSO (>5mg/ml)
Long Term Storage: -20°C
Handling: Protect from light.

-20°C

ALX-270-484-M005   AGK2   品牌 Alexis

AGK2

货号： ALX-270-484-M005      产品名称： AGK2   品牌： Alexis 规格： 5 mg 3周到货 生化实验

AGK2
SIRT2 inhibitor
Potent, selective and cell permeable inhibitor of sirtuin 2 (SIRT2) (IC50=3.5μM). Rescues α-synuclein-mediated toxicity. Modifies inclusion morphology in a cellular model of Parkinson’s disease. Protects against dopaminergic cell death. Leads to an increase in acetylated tubulin.
Product Specification
Alternative Name: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Formula: C23H13Cl2N3O2
MW: 434.3
CAS: 304896-28-4
Purity: ≥95%
Identity: Identity determined by MS, 1H- and 13C-NMR.
Appearance: Yellow solid.
Solubility: Soluble in DMSO (>5mg/ml)
Long Term Storage: -20°C
Handling: Protect from light.

-20°C