Anti-Mitochondrial fission 1 prot (Fis1)

货号： ABC67      产品名称： Anti-Mitochondrial fission 1 prot (Fis1)   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Mitochondrial fission 1 protein (Fis1)
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Mitochondrial fission 1 protein (Fis1) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes the cytoplasmic topological domain of Mitochondrial fission 1 protein.
Molecular Weight:
~17 kDa observed
Epitope:
Cytoplasmic topological domain
Immunogen:
KLH-conjugated-linear peptide corresponding to the cytoplasmic topological domain of human Mitochondrial fission 1 protein.
Background Information:
Mitochondrial fission 1 protein, hFIs1, is an overexpressed mammlian protein that is localized to the outer mitochondrial membrane of various cell types. It is involved in the fragmentation of the mitochondrial network and its perinuclear clustering, resulting in the release of cytochrome c from the mitochondrion, and apopotosis. It is known to mediate peroxisomal fission and also plays a critical role in histone function by demethylating Lys-4 of histone H3.
View All »
Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with Human.
Other homologies: Rat and Mouse (83% sequence homology).
Control:
Raji cell lysate
Quality Assurance:
Evaluated by Western Blot in Raji cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitochondrial fission 1 protein in 10 µg of Raji cell lysate.
Purification Method:
Affinity Purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q9Y3D6
Entrez Gene Number:
NP_057152
Gene Symbol:
FIS1
TTC11
CGI-135
Alternate Names:
FIS1 homolog
hFis1
Tetratricopeptide repeat protein 11
TPR repeat protein 11
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission.
UniProt Summary:
FUNCTION: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
SUBUNIT STRUCTURE: Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5.
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
View All »
Product Name:
Anti-Mitochondrial fission 1 protein (Fis1)
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit
Applications:
Detect Mitochondrial fission 1 protein (Fis1) using this Anti-Mitochondrial fission 1 protein (Fis1) Antibody validated for use in 2-8℃