Anti-pan Neurexin-1-alpha

货号： ABN161      产品名称： Anti-pan Neurexin-1-alpha   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-pan Neurexin-1
Close
REFERENCES
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.
Bottos, Alessia, et al. (2009) Proc. Natl. Acad. Sci. U.S.A., 106: 20782-7 (2009)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  WB, IHC, ICC, IP Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-pan Neurexin-1 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
Pan Neurexin 1 and there is a 75% overlap with Neurexin 2 and 3.
Molecular Weight:
~160 kDa observed
Epitope:
C terminus, 100% conserved between alpha and beta versions of Neurexin 1.
Immunogen:
KLH-conjugated linear peptide corresponding to human pan Neurexin-1-alpha.
Background Information:
Neurexin (NRXN) is a presynaptic single pass transmembrane protein that assists in joining neurons together at the synapse. Neurexins mediate signaling across the synapse and neural networks by specifying synpatic function. Studies have shown mutations in the genese encoding for neurexins are impicated in autism, schizphrenia, and nicotine dependence. There are two classifications of neurexins, α-NRXNs and β-NRXNs. The α-NRXNs are larger and have different amino-terminal extracellular sequences than β-NRXNs. β-NRXNs acta as receptors for neuroligin and has been found to play a role in angiogenesis. Pan-neurexin antibodies recognize all neurexin isoforms.
View All »
Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Demonstrated to react with Human, Mouse, and Rat.
Application Notes:
Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected pan Neurexin-1-alpha in normal mouse cerebellum and normal rat cerebellum tissues.
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in E18 chicken embryo arteries. (Bottos, A., et al. (2009). Proc Natl Acad Sci USA. 106(49):20782-20787.)
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in E18 chicken brain arteries. (Bottos, A., et al. (2009). Proc Natl Acad Sci USA. 106(49):20782-20787.)
View All »
Control:
Mouse brain membrane tissue lysate
Quality Assurance:
Evaluated by Western Blot in mouse brain membrane tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected pan Neurexin-1-alpha on 10 µg of mouse brain membrane tissue lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in preservative free buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
Q9ULB1
Entrez Gene Number:
NP_001129131
Gene Symbol:
NRXN1
Alternate Names:
Neurexin-1-alpha
Neurexin I-alpha
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key App -20℃