Thromboxane B2 Express EIA Kit – Monoclonal

货号： 10004023-480S      产品名称： Thromboxane B2 Express EIA Kit – Monoclonal   品牌： Cayman 规格： 480 solid wells ３周

Thromboxane B2 Express EIA Kit – Monoclonal
Cayman Chemical Item Number 10004023
Description
Limit of detection: 80% B/B0: 45 pg/ml · Sensitivity: 50% B/B0: 176 pg/ml · Thromboxane A2 (TXA2) is produced from arachidonic acid by many cells and causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle. 1↗,2↗,3↗ TXA2 is rapidly hydrolyzed non-enzymatically to TXB2, which is then quickly metabolized to urinary metabolites for clearance by the kidneys. Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis,4↗ while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2 secretion.5↗,6↗ Cayman’s Thromboxane B2 (TXB2) Express EIA is a competitive assay that provides accurate measurements of TXB2 from a variety of sample types. As the name implies, this kit was designed for rapid measurements of TXB2. Features of the kit include: Fast – two hour incubation; 1 hour development · Standard curve range: 15.6 – 2,000 pg/ml · Patented AChE Tracer technology · Applicable to TXB2 measurements in plasma, urine, and cell culture.
1 Hamberg, M., Svensson, J., and Samuelsson, B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 72 2994-2998 (1975).
2 Ellis, E.F., Oelz, O., Roberts, L.J., et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A2. Science 193 1135-1137 (1976).
3 Salzman, P.M., Salmon, J.A., and Moncada, S. Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery. J Pharmacol Exp Ther 215 240-247 (1980).
4 Patrono, C., Ciabattoni, G., Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Adv Prostaglandin Thromboxane Leukot Res 11 493-498 (1983).
5 Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal Biochem 155 198-205 (1986).
6 Patrono, C., Ciabattoni, G., Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 77 590-594 (1986).
Synonyms TXB2 Express ELISA Kit – Monoclonal
Formal Name 
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere 
Specificity Thromboxane B2 100%
Thromboxane B3 10.1%
2,3-dinor Thromboxane B2 7.9%

-20°C

Thromboxane B2 Express EIA Kit – Monoclonal

货号： 10004023-96S      产品名称： Thromboxane B2 Express EIA Kit – Monoclonal   品牌： Cayman 规格： 96 solid wells ３周

Thromboxane B2 Express EIA Kit – Monoclonal
Cayman Chemical Item Number 10004023
Description
Limit of detection: 80% B/B0: 45 pg/ml · Sensitivity: 50% B/B0: 176 pg/ml · Thromboxane A2 (TXA2) is produced from arachidonic acid by many cells and causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle. 1↗,2↗,3↗ TXA2 is rapidly hydrolyzed non-enzymatically to TXB2, which is then quickly metabolized to urinary metabolites for clearance by the kidneys. Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis,4↗ while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2 secretion.5↗,6↗ Cayman’s Thromboxane B2 (TXB2) Express EIA is a competitive assay that provides accurate measurements of TXB2 from a variety of sample types. As the name implies, this kit was designed for rapid measurements of TXB2. Features of the kit include: Fast – two hour incubation; 1 hour development · Standard curve range: 15.6 – 2,000 pg/ml · Patented AChE Tracer technology · Applicable to TXB2 measurements in plasma, urine, and cell culture.
1 Hamberg, M., Svensson, J., and Samuelsson, B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 72 2994-2998 (1975).
2 Ellis, E.F., Oelz, O., Roberts, L.J., et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A2. Science 193 1135-1137 (1976).
3 Salzman, P.M., Salmon, J.A., and Moncada, S. Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery. J Pharmacol Exp Ther 215 240-247 (1980).
4 Patrono, C., Ciabattoni, G., Patrignani, P., et al. Evidence for a renal origin of urinary thromboxane B2 in health and disease. Adv Prostaglandin Thromboxane Leukot Res 11 493-498 (1983).
5 Lawson, J.A., Patrono, C., Ciabattoni, G., et al. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation. Anal Biochem 155 198-205 (1986).
6 Patrono, C., Ciabattoni, G., Pugliese, F., et al. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 77 590-594 (1986).
Synonyms TXB2 Express ELISA Kit – Monoclonal
Formal Name 
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere 
Specificity Thromboxane B2 100%
Thromboxane B3 10.1%
2,3-dinor Thromboxane B2 7.9%

-20°C