标签： su

SU-5402

货号： 1645-1      产品名称： SU-5402   品牌： Biovision 规格： 1 mg 3周到货 生化实验

SU-5402
Product Overview
Product Name: SU-5402
Alternate Name/Synonyms: 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-meth yl-1H-pyrrole-3-propanoic acid
Description: A potent and selective inhibitor of fibroblast growth factor receptor (FGFR) (IC₅₀ = 0.03 µM for FGFR1) and vascular endothelial growth factor receptors (VEGFR) (IC₅₀ = 0.02 µM for VEGFR2). In addition, integrin β4-induced differentiation of neural stem cells was attenuated by SU 5402.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 215543-92-3
Molecular Formula: C₁₇H₁₆N₂O₃
Molecular Weight: 296.32
Purity: ≥97% by HPLC
Solubility:DMSO (100 mM) )
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
InChi: InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChi Key: JNDVEAXZWJIOKB-JYRVWZFOSA-N
PubChem CID: 5289418
MDL Number: MFCD08235144
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

SU 1498

货号： 1836-1      产品名称： SU 1498   品牌： Biovision 规格： 1 mg 3周到货 生化实验

SU 1498
A VEGFR2 inhibitor
Product Overview
Product Name: SU 1498
Alternate Name/Synonyms: Tyrphostin SU 1498; (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
Description: A potent and selective inhibitor (IC₅₀ = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC₅₀ >50 µM), EGFR-kinase (IC₅₀ >100 µM)and HER-2 kinase (IC₅₀>100 µM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.
Peptide Sequence: N/A
Appearance: Yellow powder
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₅H₃₀N₂O₂
Molecular Weight: 390.52
Purity: ≥98% by TLC
Solubility:DMSO (~20 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2
InChi: InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
InChi Key: JANPYFTYAGTSIN-FYJGNVAPSA-N
PubChem CID: 5941539
MDL Number: MFCD03453026
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

SU 1498

货号： 1836-5      产品名称： SU 1498   品牌： Biovision 规格： 5 mg 3周到货 生化实验

SU 1498
A VEGFR2 inhibitor
Product Overview
Product Name: SU 1498
Alternate Name/Synonyms: Tyrphostin SU 1498; (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
Description: A potent and selective inhibitor (IC₅₀ = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC₅₀ >50 µM), EGFR-kinase (IC₅₀ >100 µM)and HER-2 kinase (IC₅₀>100 µM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.
Peptide Sequence: N/A
Appearance: Yellow powder
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₅H₃₀N₂O₂
Molecular Weight: 390.52
Purity: ≥98% by TLC
Solubility:DMSO (~20 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2
InChi: InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
InChi Key: JANPYFTYAGTSIN-FYJGNVAPSA-N
PubChem CID: 5941539
MDL Number: MFCD03453026
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

SU 6668

货号： 1931-5      产品名称： SU 6668   品牌： Biovision 规格： 5 mg 3周到货 生化实验

SU 6668
A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases
Product Overview
Product Name: SU 6668
Alternate Name/Synonyms: 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Description: Cell-permeable. A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC₅₀ values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively. Acts as a potent antiangiogenic and antitumor agent.
Peptide Sequence: N/A
Appearance: Orange red solid
Formulation: N/A
CAS Number: 252916-29-3
Molecular Formula: C₁₈H₁₈N₂O₃
Molecular Weight: 310.35
Purity: ≥98%
Solubility:DMSO (~100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light
SMILES: CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O
InChi: InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9+
InChi Key: NHFDRBXTEDBWCZ-NTEUORMPSA-N
PubChem CID: 5995546
MDL Number: MFCD00149792
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

SU 11274

货号： 1938-5      产品名称： SU 11274   品牌： Biovision 规格： 5 mg 3周到货 生化实验

SU 11274
A Met inhibitor
Product Overview
Product Name: SU 11274
Alternate Name/Synonyms: 3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
Description: A specific, ATP-competitive small molecule inhibitor of the catalytic activity of Met. Displays selectivity for Met enzyme versus a panel of other tyrosine kinases with the following IC₅₀ values: Met = 0.02 μM, Flk = 1.3 μM, EGFR = >100 μM, PDGFßR = >20 μM, Tie2 = >100 μM, c-src = >10 μM, cdk2 = >10 μM, and FGFR-1 = 9.7 μM). Inhibition of the Met kinase activity by SU11274 leads to time- and dose-dependent reduced cell growth and induced G1 cell cycle arrest and apoptosis.
Peptide Sequence: N/A
Appearance: Orange solid
Formulation: N/A
CAS Number: 658084-23-2
Molecular Formula: C₂₈H₃₀ClN₅O₄S
Molecular Weight: 568.09
Purity: ≥98% by HPLC
Solubility:DMSO (~ 10 mg/ml on warming)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light
SMILES: CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
InChi: InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
InChi Key: FPYJSJDOHRDAMT-KQWNVCNZSA-N
PubChem CID: 9549297
MDL Number: MFCD08276928
USAGE: For Research Use Only! Not For Use in Humans.

-20°C