标签： smc

05-786   A-PH-SMC1(SER957),CL 5D11G5 200UG   品牌 Millipore

A-PH-SMC1(SER957),CL 5D11G5 200UG

货号： 05-786      产品名称： A-PH-SMC1(SER957),CL 5D11G5 200UG   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5
Species Reactivity Key Applications Host Format Antibody Type
H, M  WB Mouse Purified Monoclonal Antibody
Description:
Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Product Overview:
SMC1 is a ATPase and subunit of the multiprotein cohesin complex, a protein involved in chromosome segregation and in double-strand DNA break (DSB) repair. Serine 957 is phosphorylated by ATM in response to DSBs and is involved in the S-phase DNA damage checkpoint.
Specificity:
phospho-SMC1 (Ser957)
Molecular Weight:
Mr 150kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 951-962 (SQEEGS[pS]QGEDS) of human SMC1
Modifications:
Phosphorylation
Clone:
5D11G5
Isotype:
IgG1
Species Reactivity:
Human
Mouse
Species Reactivity Note:
Predicted to cross-react with xenopus and bovine based on sequence homology
Quality Assurance:
routinely evaluated by immunoblot on RIPA lysates from irradiated GMO536 cells and hydroxyurea treated HEK293 cells
Purification Method:
Protein G purfied
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
Q14683
Entrez Gene Number:
NM_006306
Gene Symbol:
SMC1A
SMCB
SMC1alpha
DXS423E
DKFZp686L19178
SMC1
SMC1L1
Smcb
OTTHUMP00000061876
KIAA0178
SB1.8
MGC138332
CDLS2
Sb1.8
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
View All »
UniProt Summary:
FUNCTION: SwissProt: Q14683 # Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phos -20°C

07-076   ANTI-SMC1 200UG PC 12-309   品牌 Millipore

ANTI-SMC1 200UG PC 12-309

货号： 07-076      产品名称： ANTI-SMC1 200UG PC 12-309   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-SMC1 Antibody
Close
REFERENCES
Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.
Schmiesing, J A, et al. (1998) Proc. Natl. Acad. Sci. U.S.A., 95: 12906-11 (1998)
Species Reactivity Key Applications Host Format Antibody Type
B, H, R, Xn  WB Rabbit Purified Polyclonal Antibody
Description:
Anti-SMC1 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Product Overview:
SMC1 is a ATPase and subunit of the multiprotein cohesin complex, a protein involved in chromosome segregation and in double-strand DNA break repair.
Specificity:
SMC1
Molecular Weight:
150kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 916-927 of human SMC1 (C-ETKLEQKRSDRH)
Isotype:
IgG
Species Reactivity:
Bovine
Human
Rat
Xenopus
Quality Assurance:
routinely evaluated by immunoblot on HeLa nuclear extract
Purification Method:
Protein A chromatography
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
Q14683
Entrez Gene Number:
NM_006306
Gene Symbol:
SMC1A
SMCB
SMC1alpha
DXS423E
DKFZp686L19178
SMC1
SMC1L1
Smcb
OTTHUMP00000061876
KIAA0178
SB1.8
MGC138332
CDLS2
Sb1.8
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.
View All »
UniProt Summary:
FUNCTION: SwissProt: Q14683 # Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
SIZE: 1233 amino acids; 143233 Da
-20°C

07-709   anti-SMC4/hCAP-C 100ul   品牌 Millipore

anti-SMC4/hCAP-C 100ul

货号： 07-709      产品名称： anti-SMC4/hCAP-C 100ul   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-SMC4/hCAP-C Antibody
Close
REFERENCES
Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A.
Yeong, Foong May, et al. (2003) Curr. Biol., 13: 2058-64 (2003)
Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.
Ono, Takao, et al. (2003) Cell, 115: 109-21 (2003)
Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
Schleiffer, Alexander, et al. (2003) Mol. Cell, 11: 571-5 (2003)
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Yeoh, Eng-Juh, et al. (2002) Cancer Cell, 1: 133-43 (2002)
View All
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Serum Polyclonal Antibody
Description:
Anti-SMC4/hCAP-C Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Product Overview:
SMC2 and SMC4 from the active ATPase subunit of Condensin I and Condensin II complexes that regulate chromosome compaction.
Specificity:
SMC4/hCAP-C
Molecular Weight:
160kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 1275-1288 (VAVNPKEIASKGLC) of human SMC4/hCAP-C (Structural maintenance of chromosomes 4/ Chromosome-associated polypeptide C. Immunizing sequence is 100% identical in rat and shares 13/14 identical amino acids in mouse.
Species Reactivity:
Human
Species Reactivity Note:
Predicted to cross-react with rat based on sequence homology.
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Storage Conditions:
2 years at -20°C
UniProt Number:
Q9NTJ3
Entrez Gene Number:
NM_001002799.1
NM_001002800.1
NM_005496.3
Gene Symbol:
SMC4
SMC4L1
CAPC
hCAP-C
CAP-C
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q9NTJ3 # Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
SIZE: 1288 amino acids; 147182 Da
SUBUNIT: Forms an heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin’s association with chromosome arms and to chromosome condensation. Dissocia -20℃

07-710   anti-SMC2/hCAP-E 100ul   品牌 Millipore

anti-SMC2/hCAP-E 100ul

货号： 07-710      产品名称： anti-SMC2/hCAP-E 100ul   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-SMC2/hCAP-E Antibody
Close
REFERENCES
Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A.
Yeong, Foong May, et al. (2003) Curr. Biol., 13: 2058-64 (2003)
Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.
Ono, Takao, et al. (2003) Cell, 115: 109-21 (2003)
Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.
Schleiffer, Alexander, et al. (2003) Mol. Cell, 11: 571-5 (2003)
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Yeoh, Eng-Juh, et al. (2002) Cancer Cell, 1: 133-43 (2002)
View All
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Serum Polyclonal Antibody
Description:
Anti-SMC2/hCAP-E Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Product Overview:
SMC2 and SMC4 from the active ATPase subunit of Condensin I and Condensin II complexes that regulate chromosome compaction.
Specificity:
SMC2/hCAP-E
Molecular Weight:
137kDa
Immunogen:
KLH-conjugated, synthetic peptide corresponding to amino acids 1184-1197 (C-KSKAKPPKGAHVEV) of human SMC2/hCAP-E (Structural Maintenance of Chromosome 2/ Chromosome-Associated Protein E) with an N-terminal cysteine added for conjugation purposes.
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Storage Conditions:
2 years at -20°C
UniProt Number:
O95347
Entrez Gene Number:
NM_001042550.1
NM_001042551.1
NM_006444.2
Gene Symbol:
SMC2
SMC2L1
hCAP-E
FLJ10093
CAPE
CAP-E
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: O95347 # Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
SIZE: 1197 amino acids; 135781 Da
SUBUNIT: Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin’s association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
DOMAIN: SwissProt: O95347 The hinge domain, which separates th -20℃